Protein Alignment mthl5 and adgrg3

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_073763566.1
• Gene: adgrg3 / 799479
• ZFINID: ZDB-GENE-140106-110
• Length: 518
• Species: Danio rerio
• Alignment Length: 499
• Identity: 98/499 - (19%)
• Similarity: 172/499 - (34%)
• Gaps: 151/499 - (30%)

  Fly   112 NCGSMQ---MWPIYHYAGSSDKLVLLDDGRLRHYTNAENEA--EERHGIQSDYEEDIAGSLEPLY 171
            ||.:::   ..|.| :..|.|.||...|....:..|..:||  ..|.|:::...||:...:..|
Zfish    50 NCSAIRPRIPTPNY-FVKSIDSLVKSLDTEKGYVINISDEALQRSRDGLENSSSEDVKLKVYLL- 112

  Fly   172 HDYDKGLYCIDKATSST---------GEENVL-------------------------FAN----- 197
               |:.|:   |.|||:         |.:.||                         |.|
Zfish   113 ---DESLF---KITSSSEIKEGNDLNGSDPVLLKQSVLGVWLGTTEVNNLSQPVQLKFRNTHNQT 171

  Fly   198 ---ICLARKEIKWSDSNFLLRKILNPIFHG--------ISLVILLV------------IAIIYFI 239
               ||:.....|....|:........|.:|        :|...:|:            :..|.::
Zfish   172 ENGICVYWHLEKNGGGNWSTDGCKTNIDNGDFVCSCNHLSFFAVLISPQIPEKSHIVHLNYISYV 236

  Fly   240 LPTLSRDLVGNIVTTIAMCLMVSQAADLVRIFTELTS-----HVSFIVA---------------- 283
            ...||.... ::|..:.:|....|....:.|..:|:|     |:||:.:
Zfish   237 GSALSIAFT-SLVIVLFLCQRKKQCEHSLVIHVQLSSCLFLLHISFLCSVWFSGHSDSDSVCQTI 300

  Fly   284 DIILCFSLLAAFFWLNSFGFYIWKTF-RSRNVFLRVTDGRKYCYYSAYAWGCTATMAALA----V 343
            .::|.:.|||.|.|....||:::... |..|::::    |.....|...||.....|.:.    |
Zfish   301 GLLLHWCLLATFTWTAIEGFHLYLLLVRVFNIYIK----RYMLKLSLMGWGVPTVTAMICGMTKV 361

  Fly   344 FAHFFLDAESYKQEHMVGEQ------ETI------GWLGICIFFAPIACTILVNIFFYVTTRKLI 396
            :..:.|..:   ||:.....      .|:      |:||:.:.|......::|     |..|:|.
Zfish   362 YGKYTLYTD---QENSTATSLCWVTTNTVIYITVNGYLGLVMLFNMAMLAVVV-----VKMRQLR 418

  Fly   397 NRRTVYGRIAHKLKANFIMFSLMLL--VMSIAWLFLIMSWLQMEGLLYA-HIVVNALQTPLLLYI 458
            .:..   :|.|:.:|.....||:.|  |:.:.|           ||.:: |   ..|..|.|...
Zfish   419 QQNV---QIDHQKRAWKDCVSLLGLCFVLGVPW-----------GLAFSTH---GPLSLPALYVF 466

  Fly   459 CVLRQRHVTF----LLKKTCCYNEPPSANDWGD-ELHYMNGNDY 497
            .:|......|    :|..||...:....:..|. ::.|::..:|
Zfish   467 TILNSFQGVFIFLWILTLTCKARKEKQTSSKGTIQVSYLSNEEY 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	61/323 (19%)
		TM helix 1	215..239	CDD:410632	5/43 (12%)
		TM helix 2	249..271	CDD:410632	3/21 (14%)
		TM helix 3	281..308	CDD:410632	8/42 (19%)
		TM helix 4	324..344	CDD:410632	4/23 (17%)
		TM helix 5	371..396	CDD:410632	4/24 (17%)
		TM helix 6	409..435	CDD:410632	6/27 (22%)
		TM helix 7	438..463	CDD:410632	7/25 (28%)
adgrg3	XP_073763566.1	None