Protein Alignment mthl5 and CALCR

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001158209.2
• Gene: CALCR / 799
• HGNCID: 1440
• Length: 490
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 84/429 - (19%)
• Similarity: 151/429 - (35%)
• Gaps: 131/429 - (30%)

  Fly    89 PMFTSYGGEQNRPVKFKFVIGIP-------NC-GSMQMWPIYHYAG-----SSDKLVLLDDGRLR 140
            |.|::.......|..|.:|:|..       .| ..||..|.|...|     :.|..:..||
Human    24 PAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDD---- 84

  Fly   141 HYTNAENEAEERHGIQS-----DYEEDIAGSLEPLYHDYDKGLYCIDKATSSTGEENVLFANICL 200
              |.|        |:.|     ||           :.|:|..    :|.|....|:.|.|.:
Human    85 --TPA--------GVLSYQFCPDY-----------FPDFDPS----EKVTKYCDEKGVWFKH--- 121

  Fly   201 ARKEIKWSD----SNFLLRKILNP--------IFHGIS---LVILLVIAIIYFILPTL------- 243
            ......||:    :.|...|:.|.        :.|.:|   |||.|.|.:.:..|.|:
Human   122 PENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNWKY 186

  Fly   244 ---------SRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADIILC--------FSL 291
                     ...|..|:..|..:..|:     ::....|:..:...:..|.:.|        :.:
Human   187 RKALSLGCQRVTLHKNMFLTYILNSMI-----IIIHLVEVVPNGELVRRDPVSCKILHFFHQYMM 246

  Fly   292 LAAFFWLNSFGFYIWKTFRSRNVFLRVTDGRKYCYYSAYAWG---CTATMAALAVFAHF----FL 349
            ...:||:...|.|: .|.....||   |:.::..:|....||   ...|:.|:....:|    :|
Human   247 ACNYFWMLCEGIYL-HTLIVVAVF---TEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWL 307

  Fly   350 DAESYKQEHMVGEQETIGWLGICIFFAPIACTILVNIFFYVT-TRKLINRRTVYGRIAHKLKANF 413
            ..|:    |:           :.|...|:...::||.||.:. .|.|:.:.    |..|:.:::.
Human   308 SVET----HL-----------LYIIHGPVMAALVVNFFFLLNIVRVLVTKM----RETHEAESHM 353

  Fly   414 IMFSL---MLLVMSIAWLFLIMSWL---QMEGLLYAHIV 446
            .:.::   |:||..:...|::..|.   :|.|.:|.:::
Human   354 YLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVM 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	53/281 (19%)
		TM helix 1	215..239	CDD:410632	9/34 (26%)
		TM helix 2	249..271	CDD:410632	3/21 (14%)
		TM helix 3	281..308	CDD:410632	6/34 (18%)
		TM helix 4	324..344	CDD:410632	5/22 (23%)
		TM helix 5	371..396	CDD:410632	7/25 (28%)
		TM helix 6	409..435	CDD:410632	4/28 (14%)
		TM helix 7	438..463	CDD:410632	2/9 (22%)
CALCR	NP_001158209.2	HRM	69..137	CDD:397086	19/99 (19%)
		7tmB1_calcitonin_R	145..434	CDD:341343	51/276 (18%)
		TM helix 1	147..172	CDD:341343	7/24 (29%)
		TM helix 2	197..219	CDD:341343	4/26 (15%)
		TM helix 3	236..263	CDD:341343	4/27 (15%)
		TM helix 4	275..295	CDD:341343	4/19 (21%)
		TM helix 5	310..339	CDD:341343	9/43 (21%)
		TM helix 6	353..380	CDD:341343	5/26 (19%)
		TM helix 7	386..411	CDD:341343	1/7 (14%)