Protein Alignment mthl5 and adgrg4a

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001429348.1
• Gene: adgrg4a / 793963
• ZFINID: ZDB-GENE-121129-2
• Length: 1201
• Species: Danio rerio
• Alignment Length: 553
• Identity: 111/553 - (20%)
• Similarity: 201/553 - (36%)
• Gaps: 128/553 - (23%)

  Fly    25 LISLLCVLLLSLNPLPVTSHVTS----AGSSTALSSD------PNLV--LVNKCCEKFEIHVDHE 77
            ::|.:|.:..:|.  .||:.:.|    .|..|..:.|      |:|.  |:|....:|. .:..|
Zfish   647 IVSEICHITTNLT--QVTNKILSITDLMGDRTVFAGDAHNMTAPSLALQLINPDTSQFH-GLTFE 708

  Fly    78 CQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGI--------PNCGS---MQMWPIYHYAGSSDKL 131
            ...| :.|....:|......:|........|.:        ||.|:   :|    :|:.|   |.
Zfish   709 VSSV-QNDGTPEIFYDENFTENPDTGTVAFISLPPTIENFFPNSGARPRVQ----FHFYG---KE 765

  Fly   132 VLLDDG----RLRHY------TNAENEAEE-------RHGIQSDYEEDIAGSLEPLYHDY----- 174
            .|.:|.    .|..|      |||.....|       || :|:..:.||   ::.:|.|:
Zfish   766 KLFEDTSSNLTLNSYVVSASVTNATVSELEIPVMVTLRH-LQNKEDWDI---VKCVYWDFNKNDK 826

  Fly   175 -----DKGLYCIDKATSST--GEENVLFANICLARKEIKWSDSNFLLRKILNPIFHGISLVILLV 232
                 |:|...::...:.|  ..:::....:.|...:...:..:..:..|::.:..|||.:.|.|
Zfish   827 KGGWNDRGCEIVNSNATQTSCSCDHLTHFGVLLDISKTPINPKDEWVLTIISYVGCGISSIFLGV 891

  Fly   233 IAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAADLVRI-FTELTSHVSFIVADIILCFSLLAAFF 296
            ..:.|.....|.||....|:..:.|.|:......||.. |....|:...|.......:..||.|.
Zfish   892 TLLTYLAFEKLRRDYPSKILINLCMALLGLNMLFLVNSWFASFNSNALCITVAAFQHYFFLATFT 956

  Fly   297 W--LNSFGFY--IWKTFRS--RNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESY- 354
            |  |.:...|  :.|.|.|  .:..|      |:|   |..||...::..|.:    .:|..||
Zfish   957 WMGLGAINMYLALVKVFNSYVPSYIL------KFC---AVGWGIPLSVVILVL----AIDFNSYG 1008

  Fly   355 --KQEHMVGEQETIGWL--GICIFFAPIACTILV---NIFFYVTTRKLINRRTVYGRIAHKLKAN 412
              ....::.|.....|.  .:..:...::..||:   ||..:|.....|          ||::.|
Zfish  1009 TSLSTDLLQESTAFCWFKNDVTFYVTVVSFAILIMVCNIIVFVVVLVQI----------HKMRVN 1063

  Fly   413 --------FI----MFSLMLLVMSIAWLFLIMSWLQME-GLLYAHIVVNALQ-TPLLLYICVLRQ 463
                    |:    :.:.:..::.:.|:.:...|...: .|:|...::|:|| ..:.|:.|:::.
Zfish  1064 KPSSSRKGFLHDLRVVASLTFLLGLTWILVFFGWGPAKTPLMYLFSILNSLQGFFIFLFYCLMKD 1128

  Fly   464 RHVTFLLKKTCC--YNEPPSANDW------GDE 488
            ..........||  :.| ...:||      ||:
Zfish  1129 NVRKQWRMHLCCGRFRE-SEYSDWSRSVPKGDK 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	58/287 (20%)
		TM helix 1	215..239	CDD:410632	7/23 (30%)
		TM helix 2	249..271	CDD:410632	5/22 (23%)
		TM helix 3	281..308	CDD:410632	7/30 (23%)
		TM helix 4	324..344	CDD:410632	5/19 (26%)
		TM helix 5	371..396	CDD:410632	5/27 (19%)
		TM helix 6	409..435	CDD:410632	3/37 (8%)
		TM helix 7	438..463	CDD:410632	7/26 (27%)
adgrg4a	NP_001429348.1	None