Protein Alignment mthl5 and adgrl2a

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_073772399.1
• Gene: adgrl2a / 57987
• ZFINID: ZDB-GENE-000607-49
• Length: 1500
• Species: Danio rerio
• Alignment Length: 307
• Identity: 71/307 - (23%)
• Similarity: 123/307 - (40%)
• Gaps: 50/307 - (16%)

  Fly   198 ICLARKEIKWSDS-NFLLRKILNPIFHGISLVILLVIAIIYFILPTLSRDLVGNIVTTIAMCLMV 261
            :.:|.:|:..:|. ..||..:::.:...:||:.|.:....:.....|..|. ..|...:.:.|.:
Zfish   840 VLMAHRELLGADKVQELLLSVISRVGIVVSLICLAMSIFTFCFFRGLQSDR-NTIHKNLCINLFI 903

  Fly   262 SQAADLVRI-FTELTSHVSFIVADIILCFSLLAAFFWLNSFGFYIWKTFRSRNVFLRVTDGRKYC 325
            ::...|:.| .||.....|.|..  ||.:..||:|.|:...|..::  .....||......|||.
Zfish   904 AELIFLIGIDMTEPKLACSIIAG--ILHYFFLASFAWMCLEGVQLY--LMLVEVFESEYSRRKYF 964

  Fly   326 YYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWLG-----ICIFFAPIACTILVN 385
            |.:.|      .:.|:.|.....:|..||      |.::.. ||.     |..|..|:...|::|
Zfish   965 YMAGY------LLPAVVVGVSAAVDFRSY------GTKKAC-WLRMDNHFIWSFIGPVTFIIMLN 1016

  Fly   386 -IFFYVTTRKLINRRTVY----GRIAH-------KLKANFIM--FSLMLLVMSIAW---LFLIMS 433
             ||..:|..|::...|..    .|:.|       ....:::|  |:|:.| :.:.|   ||.|..
Zfish  1017 LIFLLITMYKMMKHSTSLKPDSSRLEHINYEDNKPFIKSWVMGGFALLCL-LGLTWSFGLFFISE 1080

  Fly   434 WLQMEGLLYAHIVVNALQTPLLL-YICVLR---QRHVTFLLKKT-CC 475
              ....|.|...:.|..|...:. :.|:|:   :|..:..|:.| ||
Zfish  1081 --SSVVLAYLFTIFNTFQGMFIFTFHCLLQKKVRREYSKCLRHTYCC 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	64/286 (22%)
		TM helix 1	215..239	CDD:410632	3/23 (13%)
		TM helix 2	249..271	CDD:410632	4/22 (18%)
		TM helix 3	281..308	CDD:410632	8/26 (31%)
		TM helix 4	324..344	CDD:410632	4/19 (21%)
		TM helix 5	371..396	CDD:410632	9/25 (36%)
		TM helix 6	409..435	CDD:410632	8/30 (27%)
		TM helix 7	438..463	CDD:410632	6/28 (21%)
adgrl2a	XP_073772399.1	None