DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and ADGRG6

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	343	Identity:	75/343 - (21%)
Similarity:	131/343 - (38%)	Gaps:	59/343 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CIDKATSSTGEENVLFANICLAR--------KEIKWSDSNFLLR--KILNPIFH---GISLVILL 231
            |:....|...|      .:||..        .::..|.|....|  |:|..|.:   |||.:...
Human   823 CVAHRDSDASE------TVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSA 881

  Fly   232 VIAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAADLV-RIFTELTSHVSFIVADIILCFSLLAAF 295
            ...:.|.....|.||....|:..::..|:......|: ...|........|...::|.|.|||.|
Human   882 ATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATF 946

  Fly   296 FWLNSFGFYIW----KTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFA---HFFLDAES 353
            .|:.....:::    |.|   |.::|    |....:....||..|.:.::.:.:   :.....||
Human   947 TWMGLEAIHMYIALVKVF---NTYIR----RYILKFCIIGWGLPALVVSVVLASRNNNEVYGKES 1004

  Fly   354 YKQEHMVGE-----QETI-------GWLGICIFFAPIACTILVNIFFYVTTRKLINRRTVYGRIA 406
            |.:|.  |:     |:.:       |:.|: :||..||..|:|.:.......|..| ||:...:.
Human  1005 YGKEK--GDEFCWIQDPVIFYVTCAGYFGV-MFFLNIAMFIVVMVQICGRNGKRSN-RTLREEVL 1065

  Fly   407 HKLKANFIMFSLMLLVMSIAWLFLIMSWLQME-GLLYAHIVVNALQTPLLLYI--CVLRQRHVTF 468
            ..|::   :.||..| :.:.|.|...:|..:. ..:|...:.|:|| .|.::|  |.:::.....
Human  1066 RNLRS---VVSLTFL-LGMTWGFAFFAWGPLNIPFMYLFSIFNSLQ-GLFIFIFHCAMKENVQKQ 1125

  Fly   469 LLKKTCCYNEPPSAN-DW 485
            ..:..||.....:.| ||
Human  1126 WRQHLCCGRFRLADNSDW 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	58/264 (22%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	5/29 (17%)
		7tm_4	864..1111	CDD:304433	59/262 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810