DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgrf4

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_006244702.1	Gene:	Adgrf4 / 501106	RGDID:	1565216	Length:	698	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	111/510 - (21%)
Similarity:	182/510 - (35%)	Gaps:	173/510 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SSTALSSDPNLVLVNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGIPNCG 114
            ||..|.|      ||...:|.:||...| ..|:|      :|....|.:         |.....|
  Rat   215 SSDLLDS------VNSFAKKLQIHGKSE-SVVDE------LFIQTKGSR---------ISHGTSG 257

  Fly   115 SMQMWPIYHYAGSSDKLVLLDDGR--LRHYTNAENEA------------EERHGIQSDYEEDI-- 163
            :.....:..|..:.|.|||::..|  |:..::..::|            :|.|...|..::.|
  Rat   258 NSLSLSVPRYNATEDVLVLIEIPRQALQELSSNTSQAIAVAFPTLGAILKEVHQPNSSLQKPIND 322

  Fly   164 -------AGSLEPLYHDYDKGLYCIDKATSSTGEENVLFANICLA--RKEIKW--------SDSN 211
                   ...|..:...:||    |:|:.|::.:        |::  .:|.:|        ||.|
  Rat   323 LILSLVLPEGLNEIILTFDK----INKSQSTSSQ--------CVSWDAEERQWDESPCTVMSDIN 375

  Fly   212 FLLR-----------------------KILNPI-FHGI-----SLVILLVI-AIIYFILPTLSRD 246
            ..::                       .|||.| |.|:     |||:.||| ||::      ||.
  Rat   376 STVKCRCRHNKAVMSFSILMSSKPVKDMILNRITFIGLSVSIFSLVLCLVIEAIVW------SRV 434

  Fly   247 LVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSFI----------------VADIILC-FSLLAA 294
            :|..|.....:|: |:.|..|      ||::|.||                ||....| |..|:.
  Rat   435 VVTEISYMRHVCI-VNIAVSL------LTANVWFIIGSNFSANAQEDHKWCVAVTFFCHFFFLSL 492

  Fly   295 FFW------LNSFGFYIWKTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAES 353
            |||      |..:|..:        ||.|:...|......|..:||...:|.:.|  ......|.
  Rat   493 FFWMLFKALLIVYGILV--------VFRRMMKSRMMAIGFAIGYGCPLVIAVITV--SVTEPGEG 547

  Fly   354 YKQEHMVGEQETIGWL------GICIFFAPIACTILVNIFFYVTTRKLIN-RRTVYG-------R 404
            |.:....       ||      .:..|..|....:.||:...:|.  .|| :|.:.|       .
  Rat   548 YTRRDAC-------WLNWNQTKALFAFAIPALAIVAVNLLVVLTV--AINTQRPLIGSSKSQDMA 603

  Fly   405 IAHKLKANFIMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHIV---VNALQTPLLL 456
            |..::..|   .:::..::.:.|.|.:.:.|:...|:: ||:   :||.|...:|
  Rat   604 IVFRISKN---VAILTPLLGLTWGFGLTTLLEGTHLVF-HIIFALLNAFQGLFIL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	69/308 (22%)
Adgrf4	XP_006244702.1	GPS	351..394	CDD:280071	6/50 (12%)
Adgrf4	XP_006244702.1	7tm_4	408..653	CDD:304433	67/280 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810