DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl5 and Adgre4

DIOPT Version :10

Sequence 1:NP_001287291.1 Gene:mthl5 / 41438 FlyBaseID:FBgn0037960 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_001007559.1 Gene:Adgre4 / 450235 RGDID:1359641 Length:683 Species:Rattus norvegicus


Alignment Length:493 Identity:97/493 - (19%)
Similarity:181/493 - (36%) Gaps:120/493 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HVTSAGSSTALSSDPNLVL--VNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKFKF 106
            |:.:..|.|.:.|....::  .|||.:...:...:...::|.|...:.       .:||......
  Rat   166 HILNENSDTPIKSSTRDIVYETNKCKKTTILEAGNNTMKINCTSVLKE-------NKNRDETTVA 223

  Fly   107 VIGIPNCGSM----------------------------QMWPIYHYAGSSDKLVLLDDGRLRHYT 143
            .|...:.|::                            ::.|:.     |:.::|    .|::..
  Rat   224 FIAYKSLGNLLNGSFFRNKEGFQEVKLNSHIVSGAIRSEIKPVL-----SEPVIL----TLQNTQ 279

  Fly   144 NAENEAEERHGIQSDYEEDIAGSLEPLYHDYDKGLYCIDKA---------TSSTGEENVLFANIC 199
            ..::.||.........||..:.|.:...|.|....|.|.|.         ...:.|||.:.:.:.
  Rat   280 PIDSRAEHLCVYWEGSEEGGSWSTKGCSHVYTNKSYTICKCFHLSSFAVLVGLSNEENAVLSALS 344

  Fly   200 LARKEIKWSDSNFLLRKILNPIFHGISLVIL-LVIAIIYFIL--PTLSRDLVGNIVTT----IAM 257
            :.                   .:.|:||.:| |.:|.|.|:|  |      :.|..||    :::
  Rat   345 VI-------------------TYVGLSLSLLCLFLAAITFLLCRP------IQNTSTTLHLQLSI 384

  Fly   258 CLMVSQAADLVRIFTELTSHVSFIVADIILCFSLLAAFFWLNSFGFYIWKTFRSRNVFLRVTDGR 322
            ||.::....|:.|.......:..|:|. :|.:..||:|.|:...|.:::.|.|:..|......||
  Rat   385 CLFLADLLFLIGINRTKPKVLCSIIAG-MLHYLYLASFMWMFLEGLHLFLTVRNLKVANYSHSGR 448

  Fly   323 --KYCYYSAYAWGCTATMAAL-AVFAHFFLDAESY-KQEHMVGEQETIGWLG-----ICIFFAPI 378
              |...|.. .:|..|.:.|: |:..|     ::| ...|.        ||.     |..|..|:
  Rat   449 FKKRLMYPV-GYGFPALIVAVSAIAGH-----KNYGTYNHC--------WLSLHRGFIWSFLGPV 499

  Fly   379 ACTILVNIFFYVTTRKLINRR--TVYGRIAHKLKANFIMFS--LMLLVMSIAW---LFLIMSWLQ 436
            |..||:|:.||.....::..:  ::...::.......:.|.  :.|.|:..:|   ||:.....:
  Rat   500 AAIILINLVFYFQVLWILRSKLSSLNKEVSTLQDTKIMTFKAIVQLFVLGCSWGIGLFIFFEVGK 564

  Fly   437 MEGLLYAHI--VVNALQTPLLLYICVLRQRHVTFLLKK 472
            ...|::|::  ::|.||..|:..:..|..|.|....||
  Rat   565 TVRLIFAYLFTIINVLQGVLIFLVHCLLNRQVRMEYKK 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl5NP_001287291.1 7tmB3_Methuselah-like 215..474 CDD:410632 67/283 (24%)
TM helix 1 215..239 CDD:410632 7/24 (29%)
TM helix 2 249..271 CDD:410632 6/25 (24%)
TM helix 3 281..308 CDD:410632 8/26 (31%)
TM helix 4 324..344 CDD:410632 5/20 (25%)
TM helix 5 371..396 CDD:410632 9/24 (38%)
TM helix 6 409..435 CDD:410632 6/30 (20%)
TM helix 7 438..463 CDD:410632 7/26 (27%)
Adgre4NP_001007559.1 EGF_CA 75..>103 CDD:214542
GAIN <209..261 CDD:465137 4/58 (7%)
GPS 287..329 CDD:460350 8/41 (20%)
7tm_GPCRs 342..606 CDD:475119 67/301 (22%)
TM helix 1 343..367 CDD:410628 8/42 (19%)
TM helix 2 376..397 CDD:410628 5/20 (25%)
TM helix 3 407..429 CDD:410628 7/22 (32%)
TM helix 4 453..469 CDD:410628 4/16 (25%)
TM helix 5 488..511 CDD:410628 8/22 (36%)
TM helix 6 538..563 CDD:410628 6/24 (25%)
TM helix 7 568..593 CDD:410628 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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