DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgrf2

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_017173054.1	Gene:	Adgrf2 / 435529	MGIID:	2182728	Length:	673	Species:	Mus musculus

Alignment Length:	310	Identity:	60/310 - (19%)
Similarity:	121/310 - (39%)	Gaps:	65/310 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 DKATSSTGEENVLFANICLARKEIKWSDSNFLL--RKILNPIFH-------GISLVILLV-IAII 236
            |.....|.:||...| :|..|....::..:.|:  ..:.:|:..       |||:..|:: :||.
Mouse   340 DWRACKTIQENSRQA-VCRCRPNKLYTSFSILMSPNTLESPVLTYITYIGLGISICSLIICLAIE 403

  Fly   237 YFILPTLSRDLVGNI----VTTIAMCLMVSQAADLVRIFTE--LTSHVSFIVADIILCFSLLAAF 295
            ..:...:::..:..:    :..||..|:::.|..:|..|..  :..|...:.|...:.|..|:.|
Mouse   404 VLVWSQVTKTEISYLRHLCIANIAATLLMADAWFIVASFLSGPVLHHNGCVAATFFVHFFYLSVF 468

  Fly   296 FWLNS------FGFYIWKTFRSRNVFLRVTDGRKYCYYS---AYAWGCTATMAALAVFAHFFLDA 351
            ||:.:      :|..|        ||..:.   |.|..:   :..:||...:|.:.      |..
Mouse   469 FWMLAKALLILYGILI--------VFHTLP---KSCLVASLFSVGYGCPLVIAIIT------LAV 516

  Fly   352 ESYKQEHMVGEQETIGW---LGICIFFAPIACTILVNIFFYVTTRKLI--NRRTVYG-------R 404
            ....:.::..|...:.|   ..:..|..|....::||:   :|...:|  .:|...|       |
Mouse   517 TEPGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNL---ITVTMVIIKTQRAAIGSSMFQEVR 578

  Fly   405 IAHKLKANFIMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHIV---VNALQ 451
            ...::..|   .:::..::.:.|.|.|.:.:....|.: ||:   :||||
Mouse   579 AIVRICKN---IAILTPLLGLTWGFGIATVINGHSLAF-HIIFSLLNALQ 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	51/278 (18%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:383024	8/33 (24%)
		7tmB2_GPR111_115	378..644	CDD:320660	52/271 (19%)
		TM helix 1	381..405	CDD:320660	6/23 (26%)
		TM helix 2	420..441	CDD:320660	5/20 (25%)
		TM helix 3	454..476	CDD:320660	6/21 (29%)
		TM helix 4	497..513	CDD:320660	3/15 (20%)
		TM helix 5	535..558	CDD:320660	5/25 (20%)
		TM helix 6	581..606	CDD:320660	4/27 (15%)
		TM helix 7	611..636	CDD:320660	7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810