DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and adgrl4

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_998532.2	Gene:	adgrl4 / 406676	ZFINID:	ZDB-GENE-040426-2689	Length:	735	Species:	Danio rerio

Alignment Length:	396	Identity:	85/396 - (21%)
Similarity:	152/396 - (38%)	Gaps:	83/396 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PIYHYAGSSDKLVLLDD--GRLRHYTNAENEAEERHGIQSDYEEDIAG--SLEPLYHDYDKGLYC 180
            |:...|.|:.|.:.|:|  ..|:|....:...:|......:|...:.|  ||:.          |
Zfish   380 PVIAAAISNQKTLPLNDVTFTLKHTQEIDPARDETKCAFWEYSPSMMGHWSLDG----------C 434

  Fly   181 IDKATSSTGEE---NVL--FANICLARKEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIYFIL 240
            |....::|...   |.|  ||.:..:.:....:..|.|.|  :..:...|||:.|.:....::..
Zfish   435 IRTRVNTTHTSCSCNHLTHFAILMSSARANLLAHYNVLTR--ITQLGMVISLICLSMCIFTFWFF 497

  Fly   241 PTLSRDLVGNIVTTI--AMCLMVSQAADLVRIFTELTSHVSF--IVADIILCFSLLAAFFWLNSF 301
                || :.|..|||  .:|..:..|..:..|....::|..|  ::|.::..| .||||.|:...
Zfish   498 ----RD-IQNTRTTIHKNLCCSLFMAQFIFLIGINKSAHKWFCSLIAGLLHYF-FLAAFAWMCIE 556

  Fly   302 GFYIW---------KTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAAL-AVFAHFFLDAESYKQ 356
            |.:::         |.|..||.:             |:.:|..|.:.|: |...:.:....|
Zfish   557 GIHLYLIVVGVIYNKGFLHRNFY-------------AFGYGSPAVVVAISATLGYKYYGTSS--- 605

  Fly   357 EHMVGEQETIGWLG-----ICIFFAPIACTILVNIFFYVTTRKLINRRTVYGR--IAH--KLKAN 412
                     :.||.     |..|..|....||||:..:......:.|.|...:  |:|  .:::.
Zfish   606 ---------VCWLSTENNFIWSFIGPAILIILVNLLAFAVIIYKVYRHTAVKKPEISHYENIRSC 661

  Fly   413 FIMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHI--VVNALQTP-LLLYICVLRQR----HVTFLL 470
            ......:|.|:.:.|.|.:| ::..|..|.|::  ..|..|.. :.:::|||.:|    :.....
Zfish   662 ARGAIALLFVLGVTWAFGVM-YILYETTLTAYLFTFANVFQGMFIFIFLCVLSRRIQEEYYRLFK 725

  Fly   471 KKTCCY 476
            ...||:
Zfish   726 NMPCCF 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	57/263 (22%)
adgrl4	NP_998532.2	EGF_CA	34..56	CDD:304395
		EGF_CA	60..93	CDD:238011
		EGF_CA	110..143	CDD:214542
		GAIN	188..386	CDD:293098	1/5 (20%)
		GPS	416..457	CDD:280071	11/50 (22%)
		7tm_4	469..705	CDD:304433	59/269 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810