DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgre5

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001012164.1	Gene:	Adgre5 / 361383	RGDID:	1305595	Length:	825	Species:	Rattus norvegicus

Alignment Length:	265	Identity:	67/265 - (25%)
Similarity:	108/265 - (40%)	Gaps:	53/265 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 ISLVILLVIAIIYFILPTL--SRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSF---IVAD 284
            :|||.||:..:.:.::..:  ||.:|.   ..:.:||.:.....||.:..| ...|..   :||
  Rat   547 LSLVCLLLCILTFLLVKPIQSSRTMVH---LHLCICLFLGSVIFLVGVENE-GGEVGLRCRLVA- 606

  Fly   285 IILCFSLLAAFFWLNSFGFYIWKTFRSRNVFL--RVTDGRKYCYYSAYAWGCTATMAALAVFAHF 347
            ::|.|..||||.|:...|..::        ||  ||..|:....:.....|....:..:|:.|..
  Rat   607 MLLHFCFLAAFCWMALEGVELY--------FLVVRVFQGQGLSTWHRCLVGYGVPLLIVAISAAA 663

  Fly   348 FLDAESYKQEHMVGEQETIGWLG------ICIFFAPIACTILVN-IFFYVTTRKLINRRTVYGRI 405
            .:|...:         .|..||.      :..|..|:|..|..| ..|.:|..||..:.:.....
  Rat   664 RMDGYGH---------ATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSEINPN 719

  Fly   406 AHKL-KANFIMFSLM--LLVMSIAW---LFLI---MSWLQMEGLLYAHIVVNALQTPLLLYI--C 459
            ..|| ||..:..:.:  |||:...|   |||.   .:||.     |...::|.|| .|.||:  |
  Rat   720 MKKLRKARVLTITAIAQLLVLGCTWGFGLFLFNPHSTWLS-----YIFTLLNCLQ-GLFLYVTLC 778

  Fly   460 VLRQR 464
            :|.::
  Rat   779 LLNKK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	60/248 (24%)
Adgre5	NP_001012164.1	EGF_CA	69..>101	CDD:214542
		EGF_CA	171..218	CDD:284955
		EGF_CA	220..265	CDD:284955
		GPS	487..526	CDD:280071
		7tm_2	534..773	CDD:278432	63/253 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810