DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and mthl14

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	100/472 - (21%)
Similarity:	174/472 - (36%)	Gaps:	159/472 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LSSDPNL---VLVNKCCEKFEIH--VDHECQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGIPNC 113
            ||.:|.:   ||.:.|.|..|:.  :|::                              ||.| |
  Fly   144 LSFEPTIISAVLFDNCIEDLEVETTLDYD------------------------------IGNP-C 177

  Fly   114 GSMQMWPIYHYAGSSDKLVLLDDGRLRHYTNAENEAEERHGIQSDYEEDIAGSLEPLYHDYD-KG 177
            .|..:     |....|...:|.||.|.......||:                        |. |.
  Fly   178 NSSLL-----YDDKDDVFFVLQDGSLLIIDKFGNES------------------------YTVKE 213

  Fly   178 LYCIDKATSSTGEENVLFANICLAR--KEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIYFIL 240
            .||:|  ...:|.   |||..|:.:  ::|.::...|:...:|      ||:..||:::.::..|
  Fly   214 HYCLD--IDKSGH---LFAFTCVTQVEEQIAFAKVVFVAVLML------ISMPCLLLVSYLHMTL 267

  Fly   241 PTLSRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHV------SFIVADIILCFSLLAAFFWLN 299
             .|.|:|.|..::.:::||...       .|.....|:      .||  ..::.|.:|:.|||..
  Fly   268 -RLLRNLHGLSLSLMSLCLASG-------YFVHSVVHIYGIPNQGFI--GYVIQFCILSYFFWYL 322

  Fly   300 SFGFYI-----------------WKTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAV---- 343
            ...|.:                 |.||             .:..|:.:|:...||:.||.|
  Fly   323 CICFNVLLNVWYKLPCCIQCSKSWATF-------------NFACYAVFAFSGPATIVALTVQKGL 374

  Fly   344 --FAHFFLD--AESYK--QEHMVGEQETIGWLGICIFFAPIACTILVNI--FF-------YVTTR 393
              ...:||.  .||.:  |.:.:....||.:|           :.|:||  ||       |....
  Fly   375 PGMPSYFLQGLTESIRDSQRYFIPPVSTILFL-----------SFLLNIISFFGFQRISGYAKAE 428

  Fly   394 KLI-NRRTVYGRIAHK-LKANFIMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHI--VVNALQTPL 454
            |.| .|:.::.:..:: :|.:....||:.::|.::||..|:::.......|..:  :||.||...
  Fly   429 KNIQERKCLFDQQKYEDVKKDAKCVSLLGIIMVVSWLLEIITFYSGSNSNYLILCDMVNGLQGVW 493

  Fly   455 LLYICVLRQRHVTFLLK 471
            :|.|.::.:|..|.:|:
  Fly   494 VLLIFLVVRRRRTIILR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	60/284 (21%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	67/312 (21%)
		TM helix 1	241..266	CDD:320167	6/30 (20%)
		TM helix 2	275..297	CDD:320167	4/28 (14%)
		TM helix 3	306..331	CDD:320167	7/26 (27%)
		TM helix 4	349..369	CDD:320167	6/32 (19%)
		TM helix 5	389..418	CDD:320167	9/39 (23%)
		TM helix 6	445..472	CDD:320167	7/26 (27%)
		TM helix 7	477..502	CDD:320167	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010