DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and ADGRE2

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_011526250.1	Gene:	ADGRE2 / 30817	HGNCID:	3337	Length:	837	Species:	Homo sapiens

Alignment Length:	294	Identity:	60/294 - (20%)
Similarity:	120/294 - (40%)	Gaps:	58/294 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 ICLARKEIKWSDSNFLLRKILNPI-FHGISLVIL-LVIAIIYFILPTLSRDLVGNIVTTIAMCLM 260
            :.:|..:::..|      .:|..| :.|:|:.:| |::|.:.|:|....::...::...:::||.
Human   522 VLMAHYDVQEED------PVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLF 580

  Fly   261 VSQAADLVRIFTELTSHVSFIVADII---LCFSLLAAFFWLNSFGFYIWKTFR--------SRNV 314
            ::....||.|  :.|.|.  ::..||   |.:..||...|:.....|::.|.|        |.|.
Human   581 LAHLLFLVAI--DQTGHK--VLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINR 641

  Fly   315 FLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWLG-----ICIF 374
            |:     :|..:...|  |..|...|::          :..:.|:.|..... ||.     |..|
Human   642 FM-----KKLMFPVGY--GVPAVTVAIS----------AASRPHLYGTPSRC-WLQPEKGFIWGF 688

  Fly   375 FAPIACTILVNIFFYVTTRKLINRR--TVYGRIAHKLKANFIMF--SLMLLVMSIAWLFLIMSWL 435
            ..|:.....||:..::.|..::..|  ::...::.......:.|  :..|.::...|...|   |
Human   689 LGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGI---L 750

  Fly   436 QM----EGLLYAHIVVNALQ-TPLLLYICVLRQR 464
            |:    ..:.|...::|:|| ..:.|..|:|.|:
Human   751 QVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQ 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	52/264 (20%)
ADGRE2	XP_011526250.1	EGF_CA	67..117	CDD:284955
		EGF_CA	119..154	CDD:238011
		EGF_CA	163..210	CDD:284955
		EGF_CA	212..246	CDD:284955
		GPS	479..529	CDD:197639	1/6 (17%)
		7tm_4	533..774	CDD:304433	55/271 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810