DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl5 and Adgrg7

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001100568.1	Gene:	Adgrg7 / 304014	RGDID:	1307217	Length:	785	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	90/483 - (18%)
Similarity:	161/483 - (33%)	Gaps:	145/483 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VTSAGSSTALSSDPNLVLVNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKFKFVIG 109
            |....|.:.:||:.:   :||..::.:.....|.|.:..|          ||.:|
  Rat   274 VQKGSSDSLVSSETS---INKTADELKPDGQTELQILLNT----------GGNKN---------- 315

  Fly   110 IPNCGSMQMWPIY--HYAGSSDKLVLLDDGRLRHYTNAENEAEERHGIQSDYEEDIAGSLEPLYH 172
              :||    :.:|  |....|.......|...:..::..|.:|     |......:.....|.|.
  Rat   316 --SCG----FVVYQNHKLFQSKTFTATSDFSQKIISSKVNASE-----QEQNNVSVKMVFNPTYD 369

  Fly   173 DYDKGLY---CI--------------DKATSSTG------EENVLFANICLARKEIKWSDSNFLL 214
            ..:..||   |:              .|:.:::|      .....||.:...:|:.|:..|..:|
  Rat   370 KREFQLYSYACVYWNILKKDWDTAGCQKSVNASGFLGCQCNHTTNFAVLMSFKKDYKYPKSLDVL 434

  Fly   215 RKILNPIFHGISLVIL-LVIAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAA-DLVRIF------ 271
            ..|      |.:|.|. |.|.|::.|   |:|.:....||.:.:.|.:|... :|:.:|
  Rat   435 SNI------GCALSIAGLAITILFQI---LTRKIRKTSVTWVLVSLCISMLIFNLLFVFGIENSN 490

  Fly   272 -----------------------TELTSHVSFIVADIILCFSLLAAFFW----LNSFGFYIWKTF 309
                                   |..|.:.|......:|.:.||..|.|    .....|.:.:|.
  Rat   491 KNLKTSDSNINANPNENKIPETDTIETPNPSCTAIAALLHYFLLGTFTWNGLSATQLYFLLIRTM 555

  Fly   310 R--SRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDA-ESYKQEHMVGEQETIGWLGI 371
            :  .|:..:.:         |...||..|.:..:.:...:.|.. :||.:  :...||.|.||.:
  Rat   556 KPLPRHFIVII---------SLVGWGVPAIIVGVTIGIIYALSGNKSYWE--LDYRQEEICWLAV 609

  Fly   372 ------------CIFFAPIACTILVNI-FFYVTTRKLI---NRRTVYGRIAHKLKANFIMFSLML 420
                        ..|..|:...::.|| .|.:.|.|::   |:.....:....||......|: .
  Rat   610 PKNNDFARSPLLWSFIMPVTIILITNIAIFVIITVKVLWKNNQNLTSTKKVSSLKKVLSTLSI-A 673

  Fly   421 LVMSIAWLFLIMSWLQMEGLLYAHIVVN 448
            :|..:.|:|           .||.::.|
  Rat   674 VVFGVTWIF-----------AYAMLINN 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	57/291 (20%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:396408	5/39 (13%)
		7tmB2_GPR128	428..727	CDD:320385	58/295 (20%)
		TM helix 1	431..455	CDD:320385	9/32 (28%)
		TM helix 2	465..486	CDD:320385	5/20 (25%)
		TM helix 3	523..545	CDD:320385	5/21 (24%)
		TM helix 4	565..581	CDD:320385	4/24 (17%)
		TM helix 5	617..640	CDD:320385	4/22 (18%)
		TM helix 6	666..688	CDD:320385	6/33 (18%)
		TM helix 7	695..720	CDD:320385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810