DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgrf3

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_006239862.1	Gene:	Adgrf3 / 298857	RGDID:	1305868	Length:	992	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	81/389 - (20%)
Similarity:	146/389 - (37%)	Gaps:	102/389 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 DGRLRHYTNAENEAEERHGIQSDYEEDIAGSLEPLYHDY----------DKGLYCIDKATSSTGE 190
            ||  :.:|.||        :..|: ||:.|:|..::.|:          |:|  |..:|.:::..
  Rat   614 DG--QDFTQAE--------VIMDF-EDMNGTLHCVFWDHNAFQGRGGWSDEG--CELQAANASAV 665

  Fly   191 ENVLFANICLARKEIKWS----------DSNFLLRKILNPIFHGISLVILLVIAIIYFILPTLSR 245
            :       |:.|....:|          |.   |..:|:.:..|.|::.|||..:||.:   :.|
  Rat   666 Q-------CVCRHLTAFSILMSQHAVPEDP---LLDLLSQVGVGASILALLVCLVIYRL---VWR 717

  Fly   246 DLVGNIVT--------TIAMCLMVSQAADLVRIFTELTSHVSFIVADIILC-FSLLAAFFWLNSF 301
            .:|.|.|.        .:.:||:|:....|...:.....|....:|...|| |..||.|||:.:.
  Rat   718 VVVRNKVAFFRHTALFNMVICLLVADTCFLGNPWLPSGYHSLVCLATAFLCHFFYLATFFWMLAQ 782

  Fly   302 GFYIWKTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETI 366
            ...:  ..:...||.:::........|...:.|....|.:.:  ..:|....|.:|
  Rat   783 ALVL--AHQLLFVFHQLSKPLVLSMMSILGYLCPLGFAGVTL--GLYLPQRKYLRE--------- 834

  Fly   367 GWLGICI----------FFAPIACTILVN-IFFYVTTRKLINRRTVYGRIAHKLKANF-IMFSLM 419
               |.|:          |..|:...:.|| :...:...||:......|....|.:|.. ::.:|:
  Rat   835 ---GKCLLSGDGVSLHAFSEPVLAIVSVNGLVLVIAVLKLLRPSLSEGPAVEKRQALVGVLKALL 896

  Fly   420 LL--VMSIAW------LFLIMSWLQMEGLL---YAHIVVNALQTPLLLYICVLRQRHVTFLLKK 472
            :|  :..:.|      ||        ||.|   |..:::|:||...:.....|..:.|...|:|
  Rat   897 ILTPIFGLTWGLGVTTLF--------EGSLVFHYIFVILNSLQGVFIFVFGCLTDKKVLEALRK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	56/270 (21%)
Adgrf3	XP_006239862.1	HRM	353..>395	CDD:295297
		GPS	632..679	CDD:197639	10/55 (18%)
		7tm_4	687..935	CDD:304433	59/277 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810