DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgrg3

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_038954076.1	Gene:	Adgrg3 / 291854	RGDID:	1305674	Length:	574	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	85/462 - (18%)
Similarity:	146/462 - (31%)	Gaps:	158/462 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 WPIYHYAGSSDKLVLLDDGRLRHYTNAENEAEERHG---------IQSDYE------EDIA---- 164
            |....|||.::|..  .:|.:......||..||...         ::.|||      .|||
  Rat    21 WGRAGYAGQANKPP--PNGEVDPVVADENNGEEPRNPEEPRNVCRLKEDYEYNTFDLSDIAQCFT 83

  Fly   165 ------------GSLEPLYHDYDKGLY-------------CIDKATSSTGEENVLFANI--CLAR 202
                        |:|:..:.:|:..|.             .:.:..|:...|::|::.:  .:.|
  Rat    84 KCGQSDTNSCEVGNLQRYWLNYESHLLENSMETVDMPFVKALIQNISTDVSEDLLYSLVPSQIPR 148

  Fly   203 KEIKWSD---SNFLLRKILNPIFHGISLVILLVIAII------YFILPTLSRDLVGNIVTTIAMC 258
            :.::..|   ....|.|.|.....|....:.|.|.|:      .|..|.|..|...:::....:.
  Rat   149 QVMRGEDQPADRVRLPKSLFGALPGNRSAVRLAITILNIGPGNVFKGPRLLEDKGSSVLNNRMVG 213

  Fly   259 LMVSQAADLVRIFTELTSHVSFIVADIILCFS--------LLAAFFWLNSFGFYIWKTFRSRNVF 315
            |.|.|            .|.:.:...:.:.||        :|...||..:.|     .:.|....
  Rat   214 LSVGQ------------MHATGLSEPVEITFSHQHQSPNVILTCVFWDMAKG-----DWDSHGCS 261

  Fly   316 LRVTDGRKYC---YYSAYAW--------------------GCTATMAALA----VFAHFFLDAES 353
            ....|||..|   :.:.:|.                    |...:|..||    ::..|....:.
  Rat   262 TEPGDGRTVCRCDHLTFFALLLRPTLDQATARTLTRISQAGSAVSMIFLAFTMVLYVAFRFSLQR 326

  Fly   354 YKQE-----HMV------------------GEQ--ETIGWLGICIFFAPIACTI----LVNIFFY 389
            :|.|     ||.                  |.|  ....|:...||...:.|..    |.....|
  Rat   327 FKSEDAPKIHMALSTSLFLLNLTFLINVGSGSQGPPASCWVRAAIFHYFLLCVFTWMGLEAFHLY 391

  Fly   390 VTTRKLINRRTVYGRIAHKLKANFIMFSL-MLLVMSIA-----WLFLI----------MSWLQME 438
            :...|:.|  |.:|.  :.||.:.:.:.| :|:|:.:.     .::.|          :.|.|.|
  Rat   392 LLVIKVFN--TYFGH--YFLKLSLLGWGLPVLIVIGVGSSNSYGVYTIRDQENRTSLELCWFQKE 452

  Fly   439 GLLYAHI 445
            ..|||.:
  Rat   453 PALYATV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	60/320 (19%)
Adgrg3	XP_038954076.1	GPS	244..282	CDD:396408	9/42 (21%)
		7tm_GPCRs	292..551	CDD:421689	33/172 (19%)
		TM helix 1	294..319	CDD:410628	4/24 (17%)
		TM helix 2	333..355	CDD:410628	2/21 (10%)
		TM helix 3	366..393	CDD:410628	6/26 (23%)
		TM helix 4	406..426	CDD:410628	5/19 (26%)
		TM helix 5	454..481	CDD:410628	3/6 (50%)
		TM helix 6	495..522	CDD:410628
		TM helix 7	524..549	CDD:410628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810