DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001074811.1	Gene:	Adgrd1 / 243277	MGIID:	3041203	Length:	903	Species:	Mus musculus

Alignment Length:	398	Identity:	82/398 - (20%)
Similarity:	163/398 - (40%)	Gaps:	104/398 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 EDIAGSLEPLY-----HDYDKGLYCIDKATSSTGEENVLF---ANICLARKEIKWSD-------- 209
            ::::||  ||.     |...:..|     :.:|.|.|.||   |.:..:..|..||.
Mouse   504 QNLSGS--PLITVHLRHKLTQKQY-----SDATNESNRLFLYCAFLNFSSGEGVWSSQGCALTEG 561

  Fly   210 ------------SNF--LLRKILNPIFHG--------------ISLVILLVIAIIYFILPTLS-- 244
                        :||  |::.:...:.||              :|::.|....:.:.:|.::|
Mouse   562 NLTYSVCHCTHLTNFAILMQVVPLKLTHGHQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTI 626

  Fly   245 RDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADIILCFSLLAAFFWLNSFGFYIW--- 306
            |:...:|...::..::|:|...|:. |:.....|...|..::|.:..|.||.|:...|.:::
Mouse   627 RNQRYHIHANLSFAVLVAQVLLLIS-FSMEPGTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMV 690

  Fly   307 -KTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWL- 369
             |.|.|        :..|:.||....|||...:..:::.:    ..:||      |..::. ||
Mouse   691 IKVFGS--------EDSKHLYYYGIGWGCPLLICIISISS----SMDSY------GTSDSC-WLA 736

  Fly   370 ----GICIFFAPIACTILVNIFFYVTTRKLINRRT-----VYG-RIAHKLKANFIMFSLMLLVMS 424
                .|..|..|....|:|||...|...::|:..:     ::| ..|.||.|..:  :::|.::.
Mouse   737 LGSGAIWAFVGPALLVIVVNIVILVAVTRVISHISTDSYKIHGDPSAFKLTAKAV--AVLLPILG 799

  Fly   425 IAWLFLIMSWLQMEGLLYAHI--VVNALQ-TPLLLYICVLRQ------RHVTFLLKKTC----CY 476
            .:|:|.::: :....|::.::  ::|:|| ..:.|:.|:|..      :|.|.:...|.    ..
Mouse   800 TSWVFGVLA-VSDRALVFQYMFAILNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTA 863

  Fly   477 NEPPSAND 484
            |..|.::|
Mouse   864 NTKPFSSD 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	55/273 (20%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121
		GPS	539..579	CDD:280071	6/39 (15%)
		Stachel. /evidence=ECO:0000250\|UniProtKB:Q6QNK2	575..583		3/7 (43%)
		7tm_4	595..831	CDD:304433	53/258 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..903		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900