DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl5 and ADGRL2

DIOPT Version :9

Sequence 1:NP_001287291.1 Gene:mthl5 / 41438 FlyBaseID:FBgn0037960 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:535 Identity:108/535 - (20%)
Similarity:180/535 - (33%) Gaps:173/535 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VKTLGAHFAAGQNAKKCSCCALLISLLCVLLLSLNPLPVTSHVT--------SAGSSTALSSDPN 59
            :|..|:......|..|.:....|..|:.::..||.....|.:.|        ...|:.|::|...
Human   694 IKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVI 758

  Fly    60 LVLVNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGIP----------NCG 114
            .|.:||           |..:|..||               ||.|.    :|          ||.
Human   759 SVSINK-----------ESSRVYLTD---------------PVLFT----LPHIDPDNYFNANCS 793

  Fly   115 --------SMQMWPIYHYAGSSDKLVLLDDGRLR------HYTNAENEAEERHGIQSDYEEDIAG 165
                    .|..|       |:....|:|..:.|      |.||                     
Human   794 FWNYSERTMMGYW-------STQGCKLVDTNKTRTTCACSHLTN--------------------- 830

  Fly   166 SLEPLYHDYDKGLYCIDKATSSTGEENVLFANICLARKEIKWSDS-NFLLRKILNPIFHGISLVI 229
                                         || |.:|.:||.:.|. :.||..::..:...||||.
Human   831 -----------------------------FA-ILMAHREIAYKDGVHELLLTVITWVGIVISLVC 865

  Fly   230 LLVIAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADI---ILCFSL 291
            |.:....:.....|..|. ..|...:.:.|.:::...|:.|  :.|.:.  |...|   :|.|..
Human   866 LAICIFTFCFFRGLQSDR-NTIHKNLCINLFIAEFIFLIGI--DKTKYA--IACPIFAGLLHFFF 925

  Fly   292 LAAFFWLNSFGFYIWKTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQ 356
            ||||.|:...|..::  .....||......:||.|.:.|.:..|....:.|:      |.:||..
Human   926 LAAFAWMCLEGVQLY--LMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAI------DYKSYGT 982

  Fly   357 EHMVGEQETIGWLG-----ICIFFAPIACTILVNIFFYVTTR-KLINRRTVYGRIAHKLK--ANF 413
            |...       ||.     |..|..|:...||:||.|.|.|. |::.........:.:|:  .::
Human   983 EKAC-------WLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSW 1040

  Fly   414 IMFSLMLL-VMSIAWLFLIMSWLQMEGLLYAHI--VVNALQ-TPLLLYICVLRQ----------R 464
            ::.:..|| ::.:.|.|.:: ::..|.::.|::  :.||.| ..:.::.|.|::          |
Human  1041 VLGAFALLCLLGLTWSFGLL-FINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFR 1104

  Fly   465 HVTFLLKKTCCYNEP 479
            |      ..||...|
Human  1105 H------SYCCGGLP 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl5NP_001287291.1 7tm_4 212..451 CDD:304433 58/252 (23%)
ADGRL2NP_001352934.1 Gal_Lectin 49..129 CDD:307994
OLF 142..398 CDD:321983
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460
HormR 469..533 CDD:214468
GAIN 542..764 CDD:318649 14/69 (20%)
GPS 788..840 CDD:197639 15/109 (14%)
7tmB2_Latrophilin-2 848..1105 CDD:320672 61/277 (22%)
TM helix 1 850..875 CDD:320672 6/24 (25%)
TM helix 2 884..906 CDD:320672 4/23 (17%)
TM helix 3 915..942 CDD:320672 9/28 (32%)
TM helix 4 954..974 CDD:320672 5/19 (26%)
TM helix 5 991..1020 CDD:320672 10/28 (36%)
TM helix 6 1036..1063 CDD:320672 4/27 (15%)
TM helix 7 1067..1092 CDD:320672 5/24 (21%)
Latrophilin 1104..1469 CDD:308136 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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