DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl5 and ADGRL1

DIOPT Version :9

Sequence 1:NP_001287291.1 Gene:mthl5 / 41438 FlyBaseID:FBgn0037960 Length:497 Species:Drosophila melanogaster
Sequence 2:XP_016881964.1 Gene:ADGRL1 / 22859 HGNCID:20973 Length:1506 Species:Homo sapiens


Alignment Length:320 Identity:77/320 - (24%)
Similarity:134/320 - (41%) Gaps:46/320 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 ICLARKEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIYFILPTLSRDLVGNIVTTIAMCLMVS 262
            :.:|.:||.....|.||..::..:...||||.|.:....:..|..|..|. ..|...:.:.|.::
Human   851 VLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDR-NTIHKNLCINLFLA 914

  Fly   263 QAADLVRIFTELTSH-VSFIVADIILCFSLLAAFFWLNSFGFYIW----KTFRSRNVFLRVTDGR 322
            :...||.|  :.|.: ::..:...:|.:..||||.||...|.:::    :.|.|.  :.|.    
Human   915 ELLFLVGI--DKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESE--YSRT---- 971

  Fly   323 KYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWLG-----ICIFFAPIACTI 382
            ||.|...|.:      .||.|.....:|..||..|...       ||.     |..|..|::..|
Human   972 KYYYLGGYCF------PALVVGIAAAIDYRSYGTEKAC-------WLRVDNYFIWSFIGPVSFVI 1023

  Fly   383 LVN-IFFYVTTRKLINRRTVYGRIAHKLKANFIMFSL----MLLVMSIAWLFLIMSWLQMEGLLY 442
            :|| :|..||..|:|...:|....:.:|. |...::|    :|.::.:.|.|.:: ::..|.::.
Human  1024 VVNLVFLMVTLHKMIRSSSVLKPDSSRLD-NIKSWALGAIALLFLLGLTWAFGLL-FINKESVVM 1086

  Fly   443 AHI--VVNALQ-TPLLLYICVLRQR-HVTF---LLKKTCCYNEPPSANDWGDELHYMNGN 495
            |::  ..||.| ..:.::.|.|::: |..:   |....||...||.......:...|..|
Human  1087 AYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSN 1146

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl5NP_001287291.1 7tm_4 212..451 CDD:304433 62/255 (24%)
ADGRL1XP_016881964.1 Gal_Lectin 48..128 CDD:396628
OLF 143..399 CDD:413369
PHA03247 <399..503 CDD:223021
HormR 484..547 CDD:214468
GAIN 557..782 CDD:406802
GPS 806..858 CDD:197639 1/6 (17%)
7tmB2_Latrophilin-1 865..1122 CDD:320673 67/280 (24%)
TM helix 1 868..892 CDD:320673 5/23 (22%)
TM helix 2 901..922 CDD:320673 4/20 (20%)
TM helix 3 932..954 CDD:320673 7/21 (33%)
TM helix 4 973..989 CDD:320673 6/21 (29%)
TM helix 5 1008..1031 CDD:320673 7/22 (32%)
TM helix 6 1058..1080 CDD:320673 4/22 (18%)
TM helix 7 1084..1109 CDD:320673 5/24 (21%)
Latrophilin 1121..1506 CDD:396778 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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