Protein Alignment mthl5 and ADGRG3

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_005255899.1
• Gene: ADGRG3 / 222487
• HGNCID: 13728
• Length: 596
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 72/349 - (20%)
• Similarity: 117/349 - (33%)
• Gaps: 97/349 - (27%)

  Fly   180 CIDKATSSTGEENVLFANICLARKEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIY-FILPTL 243
            |.|..|        .||  .|.|..:..|..:.|.|  ::....|:|::.|....|:| |:.|.|
Human   245 CCDHLT--------FFA--LLLRPTLDQSTVHILTR--ISQAGCGVSMIFLAFTIILYAFLSPGL 297

  Fly   244 SR---------DL-VGNIVTTI-----------------AMCLMVS----QAADLVRIFTELTS- 276
            ..         || .|.|....                 |..|.:|    ::.|..:|...|..
Human   298 GHGPHPQQAECDLPAGRIAGPCERGLERQEKLPPAPQGGAWHLRLSRERFKSEDAPKIHVALGGS 362

  Fly   277 ----HVSFIV---------------ADIILCFSLLAAFFWLNSFGFYIW-KTFRSRNVFLRVTDG 321
                :::|:|               ...:..:.||.||.|:....|::: ...|..|.:.    |
Human   363 LFLLNLAFLVNVGSGSKGSDAACWARGAVFHYFLLCAFTWMGLEAFHLYLLAVRVFNTYF----G 423

  Fly   322 RKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWLGICIF---FAPIACTIL 383
            ..:...|...||..|.|.....      .|.||.. :.:.::|....|.:|.|   ....|..|.
Human   424 HYFLKLSLVGWGLPALMVIGTG------SANSYGL-YTIRDRENRTSLELCWFREGTTMYALYIT 481

  Fly   384 VNIFFYVT-----------TRKL--INRRTVYGRIAHKLKANFIMFSLMLLVMSIAWLFLIMSWL 435
            |:.:|.:|           ..|:  ::|.|.........|....:..|..|| .:.|...|.:.|
Human   482 VHGYFLITFLFGMVVLALVVWKIFTLSRATAVKERGKNRKKVLTLLGLSSLV-GVTWGLAIFTPL 545

  Fly   436 QMEGLLYAHIVVNALQTPLLLYIC 459
            .: ..:|...:.|:||.   ::||
Human   546 GL-STVYIFALFNSLQG---VFIC 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	63/314 (20%)
		TM helix 1	215..239	CDD:410632	6/24 (25%)
		TM helix 2	249..271	CDD:410632	6/42 (14%)
		TM helix 3	281..308	CDD:410632	7/42 (17%)
		TM helix 4	324..344	CDD:410632	5/19 (26%)
		TM helix 5	371..396	CDD:410632	8/40 (20%)
		TM helix 6	409..435	CDD:410632	6/25 (24%)
		TM helix 7	438..463	CDD:410632	6/22 (27%)
ADGRG3	XP_005255899.1	GPS	214..255	CDD:460350	5/19 (26%)
		7tmB2_GPR97	265..574	CDD:320558	64/319 (20%)
		TM helix 1	267..292	CDD:320558	7/26 (27%)
		TM helix 2	353..375	CDD:320558	4/21 (19%)
		TM helix 3	386..413	CDD:320558	6/26 (23%)
		TM helix 4	426..446	CDD:320558	5/25 (20%)
		TM helix 5	475..504	CDD:320558	5/28 (18%)
		TM helix 6	518..545	CDD:320558	6/27 (22%)
		TM helix 7	547..572	CDD:320558	6/23 (26%)