Protein Alignment mthl5 and ADGRG5

DIOPT Version :10

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_011521251.2
• Gene: ADGRG5 / 221188
• HGNCID: 19010
• Length: 592
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 111/593 - (18%)
• Similarity: 184/593 - (31%)
• Gaps: 219/593 - (36%)

  Fly    13 GQNAKKCSCCALLISLLCVLLLSLNPLPVTSHVTSAGSSTALSSDPNLVLVNKCCEKFEIHVDHE 77
            |.:|:....|..|...||:|.|        .:.|:......||...|:.:.......|.....|:
Human    59 GDSAQGMDHCGALFLCLCLLTL--------QNATTETWEELLSYMENMQVSRGRSSVFSSRQLHQ 115

  Fly    78 CQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGIPNCGSMQMWPIYHYAGSSDKLVLLDDGRLRHY 142
            .:|:       .:.||:.|       :...:..|...|:.......::|.|     |....|:..
Human   116 LEQM-------LLNTSFPG-------YNLTLQTPTIQSLAFKLSCDFSGLS-----LTSATLKRV 161

  Fly   143 TNAENE-AEERHGIQSDYEEDIAGSLEPLYHDYDK------GLYCI---------DKATSSTGEE 191
            ..|..: |..:|.:|...|         |..|..|      .|.||         |:..||....
Human   162 PQAGGQHARGQHAMQFPAE---------LTRDACKTRPRELRLICIYFSNTHFFKDENNSSLLNN 217

  Fly   192 NVLFANI----------------------------CL-----ARKEIKW-------------SDS 210
            .||.|.:                            |:     |||: .|             |.|
Human   218 YVLGAQLSHGHVNNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQ-PWGGWSPEGCRTEQPSHS 281

  Fly   211 NFLLRKILNPIFHGISLVIL--------LVIAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAADL 267
            ..|.|  .|.:.:...|:.|        |:..:.|..|...|..:|.:::|.:.......|:..|
Human   282 QVLCR--CNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSL 344

  Fly   268 VRIFTELTSHVSFIVADI-----------------------ILCFSLLAAFFWLNSFGFYIWKTF 309
            .||...|  |.|.::.:|                       .|.::||:...|:...||.::...
Human   345 TRIHMNL--HASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSCLTWMAIEGFNLYLLL 407

  Fly   310 -RSRNVFLRVTDGRKYCY-YSAYAWGCTATMAALAVFAHFFLDAESYKQ--------------EH 358
             |..|:::     |:|.: .....||..|.:..|::         |.|.              |:
Human   408 GRVYNIYI-----RRYVFKLGVLGWGAPALLVLLSL---------SVKSSVYGPCTIPVFDSWEN 458

  Fly   359 MVGEQETIGWLGICIFFAPIACTILV-------NIFFYV-------TTRKLINRR---------- 399
            ..|.|.    :.||...:|:..::||       ::|..|       |.|:|..|.
Human   459 GTGFQN----MSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSVRACHD 519

  Fly   400 --TVYGRIAHKLKANFIMFSLMLLVMSIAWLFLIMSWLQMEGL-----LYAHIVVNALQ-TPLLL 456
              ||.|               :.:::...|.....|:    |:     |:...::|:|. ..|.|
Human   520 TVTVLG---------------LTVLLGTTWALAFFSF----GVFLLPQLFLFTILNSLYGFFLFL 565

  Fly   457 YICVLRQR 464
            :.|..|.|
Human   566 WFCSQRCR 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	62/329 (19%)
		TM helix 1	215..239	CDD:410632	6/31 (19%)
		TM helix 2	249..271	CDD:410632	4/21 (19%)
		TM helix 3	281..308	CDD:410632	7/49 (14%)
		TM helix 4	324..344	CDD:410632	5/20 (25%)
		TM helix 5	371..396	CDD:410632	9/38 (24%)
		TM helix 6	409..435	CDD:410632	2/25 (8%)
		TM helix 7	438..463	CDD:410632	7/30 (23%)
ADGRG5	XP_011521251.2	GPS	252..296	CDD:460350	10/46 (22%)
		7tmB2_GPR114	309..582	CDD:320559	57/304 (19%)
		TM helix 1	311..336	CDD:320559	5/24 (21%)
		TM helix 2	345..367	CDD:320559	6/23 (26%)
		TM helix 3	379..406	CDD:320559	6/26 (23%)
		TM helix 4	419..439	CDD:320559	4/28 (14%)
		TM helix 5	473..502	CDD:320559	5/28 (18%)
		TM helix 6	515..542	CDD:320559	5/45 (11%)
		TM helix 7	546..571	CDD:320559	6/24 (25%)