DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and mthl11

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	101/473 - (21%)
Similarity:	200/473 - (42%)	Gaps:	79/473 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NLVLVNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKF-----KFVIGIPNCGSMQM 118
            ::|:..|...|::..:|::..:|:...:.:....    :....::|     |.:.|  |..|..:
  Fly    49 DVVIPAKLTGKYDYEIDYDGDRVSVPKHIRGCVC----KLKTCIRFCCHHKKLMAG--NLCSQDV 107

  Fly   119 WP--IYHYA-------GSSDKLVLLDDGRL---------RHYT-NAENEAEERHGIQSDYEEDIA 164
            :.  .|.|.       ||..|..:|:|..:         |||: :||...   :.:.|.||.
  Fly   108 YENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETST---YDMWSLYEN--- 166

  Fly   165 GSLEPLYHDYD-----KGLYCIDKATSSTGEE-NVLFANICLARKEIKWSDSNF-LLRK--ILN- 219
            ||   |:..:|     |..:|:....:|||:. :::.|..|:.:..:|.:...| .:||  :.|
  Fly   167 GS---LFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNA 228

  Fly   220 --PIFHGISLVILLVIAI-IYFILPTLSRDLVGNIVTTIAMCLMVSQAADLVRIF--TELTSHVS 279
              |:  ..|.|..:||.| .|..||.. |.|.|.......:||.::...:::.:|  .||.:.:.
  Fly   229 SIPV--KFSSVFFMVITIAAYLWLPKF-RSLHGKCCNLYFICLAITFLLNVISLFGIFELKTPIC 290

  Fly   280 FIVADIILCFSLLAAFFWLNSFGFYIWKTFRSR--NVFLRVTDGRKYCYYSAYAWGCTATMAALA 342
            ::.. ....|:::|.|.||:...|.:|:.|..|  .||.: .....:..|:...|.....:..:.
  Fly   291 YLTG-YAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYK-NKRSSFFNYNIIVWSSAGLLTCII 353

  Fly   343 VFAHFFLDAE-SYKQEHMVGEQE----TIGWLGICIFFAPIACTILVN-IFFYVTTRKLI----- 396
            .....|::.. .......||...    |.||.....|:||:|..|::| ..|::|||.:.
  Fly   354 FLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQ 418

  Fly   397 NRRTVYGRIAHKLK---ANFIMFSLMLLVMSIAWLFLIMSWL-QMEGLLYAHIVVN---ALQTPL 454
            |::.:......||.   ||:.::..:.::|..:|...|:::: :||.:....|::|   .....:
  Fly   419 NQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGI 483

  Fly   455 LLYICVLRQRHVTFLLKK 472
            ::::.......:..|::|
  Fly   484 IIFVATFCNHEMFRLIRK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	62/267 (23%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	35/169 (21%)
		7tmB3_Methuselah-like	236..504	CDD:320167	58/269 (22%)
		TM helix 2	258..280	CDD:320167	3/21 (14%)
		TM helix 3	291..318	CDD:320167	7/27 (26%)
		TM helix 4	335..355	CDD:320167	2/19 (11%)
		TM helix 5	383..412	CDD:320167	12/28 (43%)
		TM helix 6	433..460	CDD:320167	5/26 (19%)
		TM helix 7	468..493	CDD:320167	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810