Protein Alignment mthl5 and adgrl2b.1

DIOPT Version :9

• Sequence 1: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001353776.1
• Gene: adgrl2b.1 / 110437953
• ZFINID: ZDB-GENE-130116-4
• Length: 1454
• Species: Danio rerio
• Alignment Length: 526
• Identity: 111/526 - (21%)
• Similarity: 175/526 - (33%)
• Gaps: 180/526 - (34%)

  Fly     1 MLVKTLGAHFAAGQNAKKCSCCALLISLLCVLLLSLNPLPVTSHVTSAG----SSTALSSDPNLV 61
            :|.|.|| ||.:.:||        .:.|:....|..:.|.|.||:.||.    ||....|:|.:.
Zfish   704 VLYKHLG-HFLSTENA--------TVRLMGDGGLRNHTLTVNSHILSASINKESSRVFVSEPVIF 759

  Fly    62 LVNKCCEKFEIHVDHECQQVNETDYFQPMFTSYGGEQNRPVKFKFVIGIPNCGSMQMWPIYHYA- 125
            .:.        |:|.|       :||.                      |||.      .::|:
Zfish   760 TLE--------HLDTE-------NYFN----------------------PNCS------FWNYSE 781

  Fly   126 ------GSSDKLVLLDDGRLR------HYTNAENEAEERHGIQSDYEEDIAGSLEPLYHDYDKGL 178
                  .|:....||...:..      |.||.                    ::..::.|
Zfish   782 RSMSGYWSTQGCKLLSTNKTHTTCSCSHLTNF--------------------AILMVHRD----- 821

  Fly   179 YCIDKATSSTGEENVLFANICLARKEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIYFILPTL 243
                   |..||.:|                 :.||..::..:...:|||.|.:....:.....|
Zfish   822 -------SHAGEGSV-----------------HELLLTVITRLGIAVSLVCLAISIFTFCFFRGL 862

  Fly   244 SRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADIILCFSLLAAFFWLNSFGFYIW-- 306
            ..|. ..|...:.:.|.:::...||.|.......|..::|. :|.|..||||.|:...|..::
Zfish   863 QSDR-NTIHKNLCINLFIAELLFLVGINMTEPPIVCSVIAG-VLHFFFLAAFSWMCLEGVQLFLM 925

  Fly   307 --KTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWL 369
              :.|.|.  |.|    |||.|.|.|.:.|.....:.|:      |.:||      |.::.. ||
Zfish   926 LVEVFESE--FSR----RKYYYASGYLFPCVVVGISAAI------DYKSY------GTKKAC-WL 971

  Fly   370 G-----ICIFFAPIACTILVNIFFYVTTRKLINRRTVYGRIAHKLKAN----------------F 413
            .     |..|..|:...||:|:.|.|.        |:|..:.|.:...                |
Zfish   972 RVDNHFIWSFIGPVTFIILLNLIFLVV--------TMYKMVKHSMSMKPDSSRLESIRSWVFGAF 1028

  Fly   414 IMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHIVVNALQTP-LLLYICVL----RQRHVTFLLKKT 473
            .:..|:.|..|...|||..|.:.|   .|...:.|.||.. :.::.|:|    |:.:.....:..
Zfish  1029 ALLCLLCLTWSFGLLFLNDSSVIM---AYLFSIFNTLQGMFIFVFHCLLQKKVRKEYSKCFRQSQ 1090

  Fly   474 CCYNEP 479
            ||...|
Zfish  1091 CCRTHP 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	63/263 (24%)
adgrl2b.1	NP_001353776.1	Gal_Lectin	50..130	CDD:307994
		OLF	139..395	CDD:321983
		HormR	468..528	CDD:214468
		GAIN	538..746	CDD:318649	16/50 (32%)
		GPS	770..822	CDD:197639	12/111 (11%)
		7tm_GPCRs	831..1088	CDD:333717	68/288 (24%)
		TM helix 1	834..858	CDD:320672	4/23 (17%)
		TM helix 2	867..888	CDD:320672	4/20 (20%)
		TM helix 3	898..920	CDD:320672	8/22 (36%)
		TM helix 4	939..955	CDD:320672	5/15 (33%)
		TM helix 5	974..997	CDD:320672	7/22 (32%)
		TM helix 6	1021..1046	CDD:320672	6/24 (25%)
		TM helix 7	1050..1075	CDD:320672	6/27 (22%)
		Latrophilin	1087..1454	CDD:308136	3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900