DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and adgre9

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_021333151.1	Gene:	adgre9 / 101883848	ZFINID:	ZDB-GENE-121214-61	Length:	660	Species:	Danio rerio

Alignment Length:	319	Identity:	65/319 - (20%)
Similarity:	124/319 - (38%)	Gaps:	79/319 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 TSSTGEENVLFANICLARKEIKWSDSNFLLRKILNPIFHGISLVILLVIAIIYFILPTLSRDLVG 249
            ||||..|:               ||    |.::||        ::.:::.:::|.|..||..|..
Zfish   378 TSSTPPES---------------SD----LLELLN--------LVCVIVGLVFFSLALLSFALCQ 415

  Fly   250 -----NIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADIILCFSL--LAAFFWLNSFGFYIWK 307
                 |.|..|.:|:.: .:|.|:.:.|:  ..:|.|....:.|.::  |..|.:|::|   :|.
Zfish   416 WSPGVNNVARINICISL-LSAHLLFLLTQ--QFLSLIRPQQVFCVAIAGLLHFLFLSAF---VWM 474

  Fly   308 TFRSRNVFL------RVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETI 366
            ...:..:|:      |::..:|....|.:.......:|.:.|.....|..|.|..|..
Zfish   475 FIEAVLLFICVQNLSRISSKKKEVLSSGFLCVIGYVLALVVVGVSIGLVPEGYGSEQC------- 532

  Fly   367 GWLG-----ICIFFAPIACTILVNIFFYVTTRKLINR--RTVYGRIAHKLKANFIMFSLM--LLV 422
             |:.     |..|..|:...:.:|..|::.....:|.  :.:...::...:...:.|..:  .:|
Zfish   533 -WIKTAEGFIWSFLGPVCVILALNTIFFIKIVLTLNSTLKNLNAEVSQMKQTKILAFKTLSQFVV 596

  Fly   423 MSIAWL--FLIMSWLQMEGLLYAHIVVNALQ-TPLLLYICVL----RQRHVTFLLKKTC 474
            :...|:  |.|..   .|.|....:|:|:.| |.:.:..|||    ||::      |.|
Zfish   597 LGCPWILGFFING---SEVLEILFLVLNSQQGTFIFVIYCVLNNEIRQQY------KNC 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	49/262 (19%)
adgre9	XP_021333151.1	GPS	335..380	CDD:197639	1/1 (100%)
		7tm_GPCRs	389..648	CDD:333717	57/289 (20%)
		TM helix 1	389..413	CDD:320095	6/31 (19%)
		TM helix 2	422..443	CDD:320095	5/21 (24%)
		TM helix 3	457..479	CDD:320095	5/24 (21%)
		TM helix 4	503..519	CDD:320095	2/15 (13%)
		TM helix 5	537..560	CDD:320095	5/22 (23%)
		TM helix 6	584..609	CDD:320095	5/24 (21%)
		TM helix 7	611..636	CDD:320095	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810