DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl5 and adgrf8

DIOPT Version :9

Sequence 1:NP_001287291.1 Gene:mthl5 / 41438 FlyBaseID:FBgn0037960 Length:497 Species:Drosophila melanogaster
Sequence 2:XP_021324214.1 Gene:adgrf8 / 100537224 ZFINID:ZDB-GENE-130531-41 Length:1719 Species:Danio rerio


Alignment Length:346 Identity:60/346 - (17%)
Similarity:122/346 - (35%) Gaps:103/346 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 YCIDKATSSTGEENVLFANICLARKEIKWSDSNFLLRKILN-------PIFHGISLVIL------ 230
            :..|....|.|....:|.|..|:    .|..:...::::.|       ...|..|..||      
Zfish  1325 FAFDITNQSLGNPQCVFWNFNLS----AWDSTGCEVKQVGNDSGIITCECNHTTSFSILMSPFIL 1385

  Fly   231 --LVIAIIYFILPTLSRDLVGNIVTTIAMCLMVS-------QAADLVRIFTELTSHVSFI----- 281
              |::|.|.:|..|:|       :.::.:||::.       .:|..|.:.:....|:|.:     
Zfish  1386 DSLILAYITYIGVTIS-------MISLVLCLIIEAIVWRSVTSARGVTVVSSYMRHISLVNIALS 1443

  Fly   282 --VADIILCFSL---------------------------LAAFFWLNSFGFYIWKTFRSRNVFLR 317
              :|::  ||.:                           ||.|||:...|..:  .:.:..||.:
Zfish  1444 LLIANV--CFIIGAAISDLEKPTPVGRCSPVVFFIHFFYLAVFFWMLISGMLL--LYMTVMVFGQ 1504

  Fly   318 VTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQETIGWL------GICIFFA 376
            ::..:.........:|....:|::.|       |.:...::.|.:|..  ||      .:..|..
Zfish  1505 MSRIKMIAISFPVGYGAPLLIASITV-------ASTAGPQNYVSKQAC--WLNWNESRALLAFVI 1560

  Fly   377 PIACTILVN-IFFYVTTRKLINRRTVYGRIAHKLKANFIMFSLMLLVMSIAWLFLI--MSW---- 434
            |....:.:| :...|...|::.  |..|......:.|    :..::|..:|:|..:  ::|    
Zfish  1561 PALTIVAINLVVLVVVLYKMLG--TGVGAATQPSEKN----TFFVVVRCVAFLTPLFGLTWGFGI 1619

  Fly   435 -LQMEGLLYAHI---VVNALQ 451
             ..:...|..|:   ::||.|
Zfish  1620 GTMLSSALGVHVLFTLLNAFQ 1640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl5NP_001287291.1 7tm_4 212..451 CDD:304433 52/311 (17%)
adgrf8XP_021324214.1 EGF_CA 156..189 CDD:214542
EGF_CA 324..357 CDD:214542
EGF_CA 508..>540 CDD:214542
EGF_CA 673..706 CDD:214542
Ig 899..968 CDD:325142
GPS 1337..1379 CDD:307782 7/45 (16%)
7tm_GPCRs 1387..1660 CDD:333717 48/280 (17%)
TM helix 1 1390..1414 CDD:320095 7/30 (23%)
TM helix 2 1434..1455 CDD:320095 5/22 (23%)
TM helix 3 1470..1492 CDD:320095 5/21 (24%)
TM helix 4 1513..1529 CDD:320095 2/15 (13%)
TM helix 5 1551..1574 CDD:320095 3/22 (14%)
TM helix 6 1598..1623 CDD:320095 4/24 (17%)
TM helix 7 1627..1652 CDD:320095 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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