DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl5 and adgre15

DIOPT Version :9

Sequence 1:	NP_001287291.1	Gene:	mthl5 / 41438	FlyBaseID:	FBgn0037960	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_021333205.1	Gene:	adgre15 / 100536619	ZFINID:	ZDB-GENE-121214-33	Length:	543	Species:	Danio rerio

Alignment Length:	272	Identity:	53/272 - (19%)
Similarity:	112/272 - (41%)	Gaps:	44/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 VILLVIAIIYFILPTLSRDLVG-----NIVTTIAMCLMVSQAADLVRIFTELTSHVSFIVADIIL 287
            ::.:::.:::|.|..||..|..     |.|..|.:|:.: .:|.|:.:.|:  ..:|.|....:|
Zfish   277 LVCVIVGLVFFSLALLSFALCQWSPGVNNVARINICISL-LSAHLLFLLTQ--QFLSLIRPQQVL 338

  Fly   288 CFSL--LAAFFWLNSFGFYIWKTFRSRNVFL------RVTDGRKYCYYSAYAWGCTATMAALAVF 344
            |.::  |..|.:|::|   :|....:..:|:      :::..::....|.:.......:|.:.|.
Zfish   339 CVAIAGLLHFLFLSAF---VWMFIEAVLLFICVKNLSQISSKKREVLSSGFLCVIGYVLAMVVVC 400

  Fly   345 AHFFLDAESYKQEH-MVGEQETIGWLGICIFFAPIACTILVN--IFFYVTTRKLINRRTVYGRIA 406
            ....|..|.|..|| .:...|...|    .|..|:...:.:|  :||.:........:.:...::
Zfish   401 VSIGLVPEGYGSEHCWIKTDEGFIW----SFLGPVCVILALNLILFFKIVITLNSTLKNLNAEVS 461

  Fly   407 HKLKANFIMFSLM--LLVMSIAWLFLIMSWLQ--MEGLLYAHIVVNALQ-TPLLLYICVL----R 462
            ...:...::|..:  .:|:...|   |:.:..  .|.|....::.|:.| |.:.|..|:|    |
Zfish   462 QMKQTKVMVFKTLGQFVVLGCPW---ILGFFTNGSEVLEIVFLIFNSQQGTFIFLIYCLLNNEIR 523

  Fly   463 QRHVTFLLKKTC 474
            |::      |.|
Zfish   524 QQY------KNC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl5	NP_001287291.1	7tm_4	212..451	CDD:304433	44/242 (18%)
adgre15	XP_021333205.1	GPS	219..265	CDD:197639
		7tm_GPCRs	272..531	CDD:333717	53/272 (19%)
		TM helix 1	272..296	CDD:320095	4/18 (22%)
		TM helix 2	305..326	CDD:320095	5/21 (24%)
		TM helix 3	340..362	CDD:320095	5/24 (21%)
		TM helix 4	386..402	CDD:320095	2/15 (13%)
		TM helix 5	420..443	CDD:320095	5/26 (19%)
		TM helix 6	467..492	CDD:320095	4/27 (15%)
		TM helix 7	494..519	CDD:320095	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810