DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31368 and AQR

DIOPT Version :9

Sequence 1:NP_996198.2 Gene:CG31368 / 41437 FlyBaseID:FBgn0051368 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_055506.1 Gene:AQR / 9716 HGNCID:29513 Length:1485 Species:Homo sapiens


Alignment Length:1500 Identity:929/1500 - (61%)
Similarity:1137/1500 - (75%) Gaps:72/1500 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 TVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQY 91
            ||||::::.:.|||.:||.|..|... |:..|:||.||.:||.. ...:.|:|.:||||||||.|
Human    14 TVSQINAEFVTQLACKYWAPHIKKKS-PFDIKVIEDIYEKEIVK-SRFAIRKIMLLEFSQYLENY 76

  Fly    92 LWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASS 156
            ||.:|..|.::.|:||||..|.||||||.|..|.:|:|.||.:|.||:|:|::.|..   .:...
Human    77 LWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDHFPFFFKHILKAALAE---TDGEF 138

  Fly   157 TLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWKRLLKK 221
            :|.|:|.||:|::|||||:|::|.|.|.::|:||.||..||..|.|.||::.|:.||:|..:.|.
Human   139 SLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQLARLELELKKTPKLRKFWNLIKKN 203

  Fly   222 EKDSKPE----VLWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRR 282
            ::...||    ...||.|:..||..|:.:|:|:|....|..:.|||||||:|.:|||||||||||
Human   204 DEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRR 268

  Fly   283 FFNTVLDDCHLIVRALLSPLVRREE-GKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKK 346
            :|||:|||.||:|...||.|||||| |.||.||||||||||.|||||.||::||:::||.:||.:
Human   269 WFNTILDDSHLLVHCYLSNLVRREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDR 333

  Fly   347 ITSLQRAVFAKFPSLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVP-----EEVVS 406
            |||||||.||.||.|..|||||||.||.||||.:.||.|....|.|:|::|.|:|     |:.. 
Human   334 ITSLQRAAFAHFPELYDFALSNVAEVDTRESLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTT- 397

  Fly   407 PLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKLN 471
                  .|::||.|||::|||||.||::.||:|||||||:||||||:||:|||||:.||||||||
Human   398 ------FDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLN 456

  Fly   472 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVE 536
            |||||||||||||||||||||||||||||||:||||.||:||.|.||||||||||.||.:|.|||
Human   457 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVE 521

  Fly   537 VAKPHLGEKKPSRVRADVGVTLSVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQ 601
            ||||::||..|:||||||.:.|:||..||.|||.||||||||||||:||:|||||:..|.||:.|
Human   522 VAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQ 586

  Fly   602 VGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDM-DDLQEGADDVYE 665
            ||||.|||||::||||..||||||||||||.|:||:|.:||:||.|||:.|| :.:|.||:||||
Human   587 VGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYE 651

  Fly   666 SFNILMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFND 730
            :|||:||||||||||||||||||:||||:||||.|||||:||||||.:||||.||||..:|:|||
Human   652 TFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFND 716

  Fly   731 TFMDYNHLEASFPQYNLKCEVPVEN---RQPPFRLIFEDVPI-----QKESDGEDPEEKPEEKLT 787
            ||:...||:||||.:|:|  |.||:   :.||||:.|   |:     :|..|.:..:|..||  .
Human   717 TFLSIEHLKASFPGHNVK--VTVEDPALQIPPFRITF---PVRSGKGKKRKDADVEDEDTEE--A 774

  Fly   788 KSILVQPYKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISN 852
            |:::|:|:....|||||.::||:|:|:||.||:||||||||||||:|||||||||||||||||||
Human   775 KTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISN 839

  Fly   853 IYHNHPNQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAK 917
            ||||.|.||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||:
Human   840 IYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLAR 904

  Fly   918 RMDLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEK 982
            |::||.:|::||::|||.||.:|||||||||:||.||:|||::.|::. :||....:.  .|...
Human   905 RIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVK-NKGSTLPDV--TEVST 966

  Fly   983 EFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKE 1047
            .|||.::||:||||:|||.:|:|.|:||...||:|..||.:||||||.||||:||||||||||||
Human   967 FFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKE 1031

  Fly  1048 AKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGD 1112
            |||||||||||||||.:||.|||:||||||||:|||||||||||||||||.||.:||||||||||
Human  1032 AKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGD 1096

  Fly  1113 HHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQHIF 1177
            ||||||||||||||||||||||||||.||:||||||||.|||||||:|:||.||||.|.:|.|:.
Human  1097 HHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQ 1161

  Fly  1178 ERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKISI 1242
            ...|:..||.|.::|:||||||||:|||||||||||||||.||||:||::|||.||||||.||||
Human  1162 LLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISI 1226

  Fly  1243 LTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRRLV 1307
            |||||||||||||:||.|||||||||.|:|:||||::|||||||||:|||||:||||||||||||
Human  1227 LTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLV 1291

  Fly  1308 VAMSRARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIKTV 1372
            |||||||||||:|.|||||:||.||...|..||.|||.|.::|.:.|||.| .:....|.:::.:
Human  1292 VAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTTR-KNGERPSHEVQII 1355

  Fly  1373 ENMSEMAQFVYERYMAKME----------ELKGTLPSE-EELEAMRNQLLQEDEESVPEAS--EE 1424
            :||.:||.|||..||..::          :|...:..| ||::....:|..|:|....:|.  ..
Human  1356 KNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPS 1420

  Fly  1425 PPEKRAAKEEPLSKKKTT----------EAFKPTPILNEINVDDTEMGQREQIEEEATDQDKTQE 1479
            |.:....:|.|..:..||          ||.   |.|:|  ...|.:|......|..|.||.|  
Human  1421 PTDTSCRQETPAFQTDTTPSETGATSTPEAI---PALSE--TTPTVVGAVSAPAEANTPQDAT-- 1478

  Fly  1480 SAPAE 1484
            |||.|
Human  1479 SAPEE 1483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31368NP_996198.2 Aquarius_N 33..815 CDD:293008 470/800 (59%)
AAA_11 818..1123 CDD:289831 234/304 (77%)
AAA_19 821..893 CDD:289986 68/71 (96%)
DNA2 <1012..1348 CDD:224037 268/335 (80%)
UvrD_C_2 1131..1321 CDD:304668 149/189 (79%)
AQRNP_055506.1 Helical region with structural similarity to ARM repeat domains. /evidence=ECO:0000269|PubMed:25599396 1..416 209/413 (51%)
Aquarius_N 18..802 CDD:406730 470/802 (59%)
Required for assembly of the IB complex. /evidence=ECO:0000269|PubMed:25599396 417..1485 718/1084 (66%)
EEXXQc_AQR 797..1152 CDD:350693 277/357 (78%)
SF1_C_Upf1 1140..1323 CDD:350195 138/182 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1419..1485 20/71 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152708
Domainoid 1 1.000 922 1.000 Domainoid score I44
eggNOG 1 0.900 - - E1_KOG1806
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7629
Inparanoid 1 1.050 1796 1.000 Inparanoid score I67
Isobase 1 0.950 - 0 Normalized mean entropy S2146
OMA 1 1.010 - - QHG55102
OrthoDB 1 1.010 - - D66018at33208
OrthoFinder 1 1.000 - - FOG0005435
OrthoInspector 1 1.000 - - oto89740
orthoMCL 1 0.900 - - OOG6_102954
Panther 1 1.100 - - LDO PTHR10887
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3418
SonicParanoid 1 1.000 - - X3849
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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