Protein Alignment CG31368 and SEN1

DIOPT Version :9

• Sequence 1: NP_996198.2
• Gene: CG31368 / 41437
• FlyBaseID: FBgn0051368
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_013534.3
• Gene: SEN1 / 851150
• SGDID: S000004422
• Length: 2231
• Species: Saccharomyces cerevisiae
• Alignment Length: 1915
• Identity: 352/1915 - (18%)
• Similarity: 628/1915 - (32%)
• Gaps: 680/1915 - (35%)

  Fly    26 LTVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQ 90
            |::....|.||:     .|...:|.:: .:|...::.:|:...         .||:        .
Yeast   227 LSIKTFISGVIF-----CWCEGSKEEN-EWSRAFLKDLYSRNF---------HINL--------S 268

  Fly    91 YLWPHYQRETATH-------AHLMSIVIMANEKFRER-VEVWTVFEK------------------ 129
            .|.|....|...|       |:...||:   .:|..| :.|:.:|:|
Yeast   269 NLTPDIIEEVYIHILFLQNPANWTEIVV---SQFWSRLLPVFNLFDKDVFIEYFQVPKNVESLKK 330

  Fly   130 -----LPDQYPAFFRHVLESCLPSKKAKEASSTLRERTALLMFINH------------------- 170
                 |...:..::.|:.:    |...|.....||   .|.||:|.
Yeast   331 TFKFPLEPIFKMWYNHLSK----SYHDKPLDFLLR---GLTMFLNKFGSEFWSKIEPFTFHSILD 388

  Fly   171 -CFN--SMEIELCREQAKRLV--------------------SLSMWHCLQPRRREQELREVPEWR 212
             .||  |..|:|.:.|...:|                    :|..:|.|.|.:|.|.:|:|.
Yeast   389 IIFNRDSFPIKLIKIQDNPIVEHQTEVYFQLTGSVTDLLSWTLPFYHALSPSKRIQMVRKVS--- 450

  Fly   213 KYWKRLLKKEKDSKPEVLWERHFMQNLIIDFLHILESIPAEGEVPRN-VVHYCERFLEFIIDLE- 275
                                        :.||.|:.:.|:...:|:. :::.....|..::.::
Yeast   451 ----------------------------MAFLRIIANYPSLKSIPKACLMNSATALLRAVLTIKE 487

  Fly   276 ---ALLPTRRFFNTVL----DDCHLIVRALLSPLVRREEGK---------------------LFG 312
               |:|.....|.|||    |...|:...|:..::.|....                     :..
Yeast   488 NERAMLYKNDEFETVLLTKTDSRALLNNPLIQDIIIRSASNPNDFYPGLGAASASVATSTMMVLA 552

  Fly   313 QLLDM---------LKFYTRFEINDVTGS-----SLTDH-DMTQLHYKKITSLQRAVFAKFPSLR 362
            :.:|.         .|.|:...|:::..|     ::|:. |:...|...:.:.|..|..|..:..
Yeast   553 ECIDFDILLLCHRTFKLYSGKPISEIPISTNVLENVTNKIDLRSFHDGPLLAKQLLVSLKNINGL 617

  Fly   363 VFALSNVATVDNRESLEQHFGGLDGKGLLQIATFL-----NLVPEEVVSPLDWHRV---DEQF-- 417
            :...||.|..:...:|.|.|..|..:.:.:.|..|     .::.:|..|...|..:   |:..
Yeast   618 LIVPSNTAVAEAHNALNQKFLLLSTRLMEKFADILPGQLSKILADEDASQGFWSCIFSSDKHLYQ 682

  Fly   418 ---------------LRELLITRHERRCSQLEALNEM---------------------------- 439
                           |..:|...:......|:.:|.|
Yeast   683 AATNILYNTFDVEGRLEGILAILNSNLTVNLKNINVMLQRLINCEFYEPCPRAVRVLMDVVSAFV 747

  Fly   440 -PL---YPTEQIIWDENVVPSEYYSGDSCL----ALPKLNLQFLTLHDYL-LRNFNLFRL----- 490
             |:   :...|.:..:|.........:||.    .:.|..|::.:.:||. |.||....|
Yeast   748 DPISGVFANFQTLKSQNTEKEFLKFWESCWLFLDTIYKFTLKWASKYDYSELENFTKDTLDLSRS 812

  Fly   491 -------------ESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFA--------- 533
                         :.|..:..::.:....||.|.....:|:.....|:.:..:..|
Yeast   813 LVDSFREFSDILHDQTKNLLLNVLETFKNMLYWLRLSDEVLLESCVRLIISTSDLAHEKHVKVDD 877

  Fly   534 -VVEVAKPH----------LGEKKPSRVRADVGV-TLSVRREIKAEWENLRKH----------DV 576
             :||:...:          |.|::.|.:.....: ..::..|:..|.||.||.          |:
Yeast   878 SLVEMMAKYASKAKRFSNKLTEQQASEILQKAKIFNKALTEEVATEAENYRKEKELSRLGKVIDL 942

  Fly   577 CFLITVKPT-------------------------------------QP----YGT-------KYK 593
            ...:...|:                                     ||    :||       |..
Yeast   943 TDSVPASPSLSPSLSSTIASSSAESRADYLQRKALSSSITGRPRVAQPKITSFGTFQSSANAKLH 1007

  Fly   594 HREPFVPQVGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDMDDLQE 658
            ..:|..|      :...|:..|...|.||:.  |...|....::|..     ||:   :.|...|
Yeast  1008 RTKPVKP------LSKMELARMQLLNNRVVH--PPSAPAFHTKSRGL-----SNK---NDDSSSE 1056

  Fly   659 GADDVYES----FNI----------------LMRRKPKENNFKAVLETIRHLMNTECVVPPWLHD 703
            .:|:..||    |.|                :::|:......|..||.:|..:|.:  :.| |::
Yeast  1057 ESDNDIESARELFAIAKAKGKGIQTVDINGKVVKRQTAAELAKQELEHMRKRLNVD--MNP-LYE 1118

  Fly   704 ILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEVPVENRQ----------- 757
            |:|.:.....:.|   |:.|....::|. .|:.:..|.: |..:|..:.:|:.|
Yeast  1119 IILQWDYTRNSEY---PDDEPIGNYSDV-KDFFNSPADY-QKVMKPLLLLESWQGLCSSRDREDY 1178

  Fly   758 PPFRLI---------FEDV-------PIQ----KESD----GEDPEEKPEEKLTK---------- 788
            .||.:|         |.||       .||    .|||    ...|:.:|:::|:.
Yeast  1179 KPFSIIVGNRTAVSDFYDVYASVAKQVIQDCGISESDLIVMAYLPDFRPDKRLSSDDFKKAQHTC 1243

  Fly   789 ---------------------------------------------SILVQPYK-------YEARG 801
                                                         :.:.:.|.       |:..|
Yeast  1244 LAKVRTLKNTKGGNVDVTLRIHRNHSFSKFLTLRSEIYCVKVMQMTTIEREYSTLEGLEYYDLVG 1308

  Fly   802 PYPSDKPK-------------QNSIRFTPTQVEAI-RAGMQPGLTLVVGPPGTGKTDVAVQII-- 850
            .....||.             :.|.:...:|.||| .:..:.|.:|:.||||||||...:.||
Yeast  1309 QILQAKPSPPVNVDAAEIETVKKSYKLNTSQAEAIVNSVSKEGFSLIQGPPGTGKTKTILGIIGY 1373

  Fly   851 ---------SNIY-----HNHPN-------QRTLIVTHSNQALNQLFEKIMALDIDER------H 888
                     ||:.     .|..|       |:.||...||.|::::..::.:...|::      .
Yeast  1374 FLSTKNASSSNVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEICLRLKSGVYDKQGHQFKPQ 1438

  Fly   889 LLRLGHGEEALETEKDYS-------RYGRVNYVLAKRMDLLSQVQKLQEALGVSGDNAYTCETAG 946
            |:|:|..:......||.:       |.|..||.:....:|
Yeast  1439 LVRVGRSDVVNVAIKDLTLEELVDKRIGERNYEIRTDPEL------------------------- 1478

  Fly   947 YFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPLFKGANYDELMDIAC 1011
                      ..||.:.::..:      :||.:.:.|       :..|:......:..:|.
Yeast  1479 ----------ERKFNNAVTKRR------ELRGKLDSE-------SGNPESPMSTEDISKLQ---- 1516

  Fly  1012 SNFRYISDIFNEL----EEFR---AFELLRTGLDRSKYLLVKEAKIIAMT---C-THAALKRKEL 1065
            ...|.:|.|.|||    :|.|   :.......|||..    .:|.|:|::   | |.:......|
Yeast  1517 LKIRELSKIINELGRDRDEMREKNSVNYRNRDLDRRN----AQAHILAVSDIICSTLSGSAHDVL 1577

  Fly  1066 VNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVIKNMAFQKYSN 1130
            ..:|.::|.::::|:.|..|:.:.|||....        ||.||:||.:||||.:.:.|...: .
Yeast  1578 ATMGIKFDTVIIDEACQCTELSSIIPLRYGG--------KRCIMVGDPNQLPPTVLSGAASNF-K 1633

  Fly  1131 MEQSLFTRLVRLGVPTVDLDGQGRARASI-----CSLYKWRYKKLEDLQHIFERDEYKQANPGFV 1190
            ..||||.|:.:...|.: ||.|.|...||     ...|:.|.|....:. |..:..:.|..|  :
Yeast  1634 YNQSLFVRMEKNSSPYL-LDVQYRMHPSISKFPSSEFYQGRLKDGPGMD-ILNKRPWHQLEP--L 1694

  Fly  1191 HDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAV--YMYMRL---LGYPAAKISILTTYNGQK 1250
            ..|:..::  ..|..|.......|.|:.|....:.:  |::.:.   :.: ..||.|::.|..|.
Yeast  1695 APYKFFDI--ISGRQEQNAKTMSYTNMEEIRVAIELVDYLFRKFDNKIDF-TGKIGIISPYREQM 1756

  Fly  1251 HLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVR---TK-AVGHLRDVRRLVVAMS 1311
            ..:|.......|.  :|.......|:|.:|||:.:.||||.||   || :||.|:|.||:.||::
Yeast  1757 QKMRKEFARYFGG--MINKSIDFNTIDGFQGQEKEIILISCVRADDTKSSVGFLKDFRRMNVALT 1819

  Fly  1312 RARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIKTVENMS 1376
            ||:..::|.|..             :.|.:..|...|:.:.|   ||...|...|..:....|
Yeast  1820 RAKTSIWVLGHQ-------------RSLAKSKLWRDLIEDAK---DRSCLAYACSGFLDPRNN-- 1866

  Fly  1377 EMAQFVYERYMAKMEELKGTLPSEEE--------------------LEAMRNQLLQEDEESVPEA 1421
             .||.:..::..       .:|||:|                    .:..:.:::.|.||:....
Yeast  1867 -RAQSILRKFNV-------PVPSEQEDDYKLPMEYITQGPDEVKSNKDTKKRRVVDEGEEADKAV 1923

  Fly  1422 SEEPPEKRAAKEEPLS---KKKTTEAFKPT 1448
            .::..||:..|::..:   ||...:|..|:
Yeast  1924 KKKKKEKKKEKKKSKADDKKKNNKKAESPS 1953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	188/1188 (16%)
		AAA_11	818..1123	CDD:289831	79/352 (22%)
		AAA_19	821..893	CDD:289986	28/101 (28%)
		DNA2	<1012..1348	CDD:224037	96/360 (27%)
		UvrD_C_2	1131..1321	CDD:304668	57/203 (28%)
SEN1	NP_013534.3	SEN1_N	106..859	CDD:403815	110/695 (16%)
		DNA2	1006..1858	CDD:224037	204/965 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3418
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940