DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31368 and EMB2765

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_850297.1	Gene:	EMB2765 / 818459	AraportID:	AT2G38770	Length:	1509	Species:	Arabidopsis thaliana

Alignment Length:	1489	Identity:	709/1489 - (47%)
Similarity:	959/1489 - (64%)	Gaps:	115/1489 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PPAKTTKENSG-----SLTVSQLSSDVIWQLASQYW-TPDTKADHLPYSAKIIERIYNEEIGDGG 72
            |..|..:...|     |:|:|::..|.:.::|.:.| ....|....|:..::::.||..|:....
plant    28 PAEKPLESKPGSNLPSSITLSEIQQDRLTKIAEESWIKTGGKLPEKPFDPEVVKEIYVTELKVTS 92

  Fly    73 GHS---ARRINMLEFSQYLEQYLWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQY 134
            |..   .:|:.:||.|||||.||||::..||||..|:||:::|.||||||.|..|..|....|.:
plant    93 GRKPVPLQRVMILEVSQYLENYLWPNFDPETATFEHVMSMILMINEKFRENVAAWICFHDRDDLF 157

  Fly   135 PAFFRHVLESCLPSKKAKEASS-TLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQP 198
            ..|.:.||       :.||... |:.|:|..|:|:.:.|.|:|..:..|....|..|..||.|..
plant   158 KKFLQKVL-------RLKEGRDLTIAEKTNYLVFMINAFQSLEDAVVNEIVLSLAGLQSWHSLSY 215

  Fly   199 RRREQELREVPEWRKYWKRLLKK---EKDSKPEVL-----WERHFMQNLIIDFLHILESIPAEGE 255
            .|.:.||...|:..|.|||..||   |..||.|..     .|.:|::.||.:|:.:|:......|
plant   216 GRFQMELCLQPDLIKKWKRSSKKWAAEAKSKGEKFDLSSSPEANFVRGLIEEFVEVLDHGVFADE 280

  Fly   256 VPRNV---------VHYCERFLEFIIDLEALLPTRRFFNTVLDDCHLIVRALLSPLVRREEGKLF 311
            |....         |.|||||:||:||:...|||||:...::.|..::.:..||.|.:.|:||||
plant   281 VDDTAGSQLVDDSSVLYCERFMEFLIDMLNQLPTRRYLRPLVADIAVVAKCRLSALYKHEKGKLF 345

  Fly   312 GQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKKITSLQRAVFAKFPSLRVFALSNVATVDNRE 376
            .||:|:|:||.:|||.|..|:.|||.:..|.||.:..:.|...|.|.|.|:..:|:|:.::....
plant   346 AQLVDLLQFYEKFEIKDHDGTQLTDDEALQFHYDRFMAFQLLAFKKIPKLQDLSLANIGSIHKSS 410

  Fly   377 SLEQHFGGLDGKGLLQ-IATFLNLVPEEVVSPLDWHRVDEQFLRELLITRHERRCSQLEALNEMP 440
            .|.:....|..:.|.. :.:.|.|     ||..|.....:.||.|::::..|::.||.||:|.:|
plant   411 DLRRRLSVLSLEDLRDVVCSKLKL-----VSRHDPWADSKDFLTEVVVSSFEKQQSQKEAINALP 470

  Fly   441 LYPTEQIIWDENVVPSEYYSGDSCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVS 505
            |||.|||:|||:|:||..|||:.||||||||||||||||||||||||||||||||||:||::||.
plant   471 LYPNEQIMWDESVIPSINYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIREDIQEAVP 535

  Fly   506 RMLPWKSEDGDVVFGGWARMALPIASFAVVEVAKPHLGEKKPSRVRADVGVTL-SVRREIKAEWE 569
            .:|...:.:||..|.||:|||:||..|.:.:|.:|::||:|||.|.|:|..:: |.|.:|::||.
plant   536 HLLAHINNEGDTAFRGWSRMAVPINDFKIAQVKQPNIGEEKPSSVTAEVTFSIKSYRTQIRSEWN 600

  Fly   570 NLRKHDVCFLITVKPT-QPYGTKYKHREPFVPQVGLVSVRGCEV------EG--MLDANGRVIED 625
            :|::|||.||:.::|: :|.|.:...:.....::||..|||||:      ||  |.|..|||..|
plant   601 SLKEHDVLFLLCIRPSFEPLGPEEADKATVPQRLGLQYVRGCEIIDIRDEEGNLMNDFTGRVKRD 665

  Fly   626 GPEPRPQLQGENRCYRVWLDSNQYRLDMDDLQE-GADDVYESFNILMRRKPKENNFKAVLETIRH 689
            ..:|.   :||.|...|.||:.||.:|:.|:.| ||:|||.:||:|||||||||||||:||:||.
plant   666 EWKPP---KGEMRTVTVALDAAQYHIDVTDIAEKGAEDVYGTFNVLMRRKPKENNFKAILESIRD 727

  Fly   690 LMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEVPVE 754
            |||..|:||.|||::.||||:|.||.:.||||....::|.|||::.|||..||..|    ||...
plant   728 LMNEYCIVPEWLHNVFLGYGNPSAAQWPNMPNLLEIVDFKDTFLNANHLSESFSDY----EVSFI 788

  Fly   755 NRQ--------PPFRLIFEDVPIQKESDGE---------DP-------EEKPEEKLTKSILVQPY 795
            |.:        ||||:   .:|...:.:|.         :|       :..|:|||    :|:.|
plant   789 NAEGAEALDPSPPFRI---TLPKTLKGNGAISGNKISEVNPADNVNMVDASPKEKL----IVEAY 846

  Fly   796 KYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNHPNQ 860
            .....||||.|:|||||::||||||.||.:|:|||||:|||||||||||.||||::.:|||.|:|
plant   847 TPPDPGPYPQDQPKQNSVKFTPTQVGAIISGIQPGLTMVVGPPGTGKTDTAVQILNVLYHNCPSQ 911

  Fly   861 RTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAKRMDLLSQV 925
            ||||:||||||||.||||||..|:..|:|||||.||:.|.|:.|:||.||||.:|.:|::|||:|
plant   912 RTLIITHSNQALNDLFEKIMERDVPARYLLRLGQGEQELATDLDFSRQGRVNAMLVRRLELLSEV 976

  Fly   926 QKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFF 990
            ::|..:|.:..|..|||||||||:|.:|.:|||.|   ::...|..|.:..   ....|||..||
plant   977 ERLARSLQLPEDVGYTCETAGYFWLLHVYSRWELF---LAACAGNEDNQSF---VRDRFPFKDFF 1035

  Fly   991 ADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKEAKIIAMTC 1055
            :|.|:|:|.|.::::.|..|...|.::..:|.||||.||||||::..||:.||:.|:|||:||||
plant  1036 SDTPKPVFNGESFEKDMRAAKGCFSHLKTVFQELEECRAFELLKSTADRANYLMTKQAKIVAMTC 1100

  Fly  1056 THAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVI 1120
            |||||||::.:.|||:|||:||||||||||||||||:|||...||..||||.|:||||||||||:
plant  1101 THAALKRRDFLQLGFKYDNLLMEESAQILEIETFIPMLLQRQEDGHARLKRCILIGDHHQLPPVV 1165

  Fly  1121 KNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQHIFERDEYKQA 1185
            |||||||||:|:||||||.||||:|.::|:.|||||.|:..||.|||:.|.||..:.|...:::|
plant  1166 KNMAFQKYSHMDQSLFTRFVRLGIPYIELNAQGRARPSLAKLYNWRYRDLGDLSIVKEAPIFQRA 1230

  Fly  1186 NPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKISILTTYNGQK 1250
            |.||.::|||:||.|::|.|||.|:|:||||..||||||:||:|||||||||.||||||||||||
plant  1231 NAGFSYEYQLVNVPDYEGRGESTPSPWFYQNQGEAEYIVSVYIYMRLLGYPANKISILTTYNGQK 1295

  Fly  1251 HLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRRLVVAMSRARL 1315
            .|||||||.||...|.||.|.|:|||||:||||||:||:|||||:.|||||||||||||||||||
plant  1296 LLIRDVINRRCVPYPFIGPPSKVTTVDKFQGQQNDFILLSLVRTRFVGHLRDVRRLVVAMSRARL 1360

  Fly  1316 GLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSL-VPEDKFPTDRLASAAVASQDIKTVENMSEM- 1378
            |||||.|.|||:.|.|||.||:||.|||.:|.| ..|:...|||:......|..:..||.|:.:
plant  1361 GLYVFCRRSLFEQCYELQPTFQLLLQRPDRLGLNFNENTAYTDRVVEEVENSYLVHDVEEMAHIV 1425

  Fly  1379 ---------AQFVYERY---MAKMEELKGTLPSEEELEAMRNQLLQEDEESVPEASEEP 1425
                     ||..||:|   ||:||:....:.|:..::.      .|.|:::.:.::.|
plant  1426 DDRMNKFYQAQGAYEQYQNNMAQMEDGNHDMESDSVVDG------DESEKNMQQLNQSP 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	342/839 (41%)
		AAA_11	818..1123	CDD:289831	179/304 (59%)
		AAA_19	821..893	CDD:289986	51/71 (72%)
		DNA2	<1012..1348	CDD:224037	231/335 (69%)
		UvrD_C_2	1131..1321	CDD:304668	132/189 (70%)
EMB2765	NP_850297.1	Aquarius_N	50..866	CDD:293008	342/841 (41%)
		AAA_11	865..1168	CDD:289831	182/308 (59%)
		AAA_19	881..944	CDD:289986	46/62 (74%)
		DNA2	<1091..1372	CDD:224037	202/280 (72%)
		UvrD_C_2	1176..1366	CDD:304668	132/189 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	577	1.000	Domainoid score	I42
eggNOG	1	0.900	-	-		E1_KOG1806
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7629
Inparanoid	1	1.050	1221	1.000	Inparanoid score	I18
OMA	1	1.010	-	-		QHG55102
OrthoDB	1	1.010	-	-		D867854at2759
OrthoFinder	1	1.000	-	-		FOG0005435
OrthoInspector	1	1.000	-	-		oto3365
orthoMCL	1	0.900	-	-		OOG6_102954
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3849
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840