DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31368 and setx

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	912	Identity:	181/912 - (19%)
Similarity:	330/912 - (36%)	Gaps:	282/912 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   691 MNTECVVP---PWLHD-ILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEV 751
            ::.||.|.   |...| :||...|...|:..:.||      |:|....:.::..|
Zfish  1583 LSQECDVKQIYPKEDDLVLLWLPDNTGAYAQDEPN------FHDLHPHFGYVSRS---------- 1631

  Fly   752 PVENRQPPFRLIFEDVPIQKESDGEDPEEKP--------------EEK----LTKSILVQP---- 794
            .|.||.|..|... ::.||...:......:|              |.:    |....:::|
Zfish  1632 NVLNRTPGSRSTL-NLTIQTRGNVSSVNSQPVLCEVVGSLISIFREFRALCLLRNGPMLRPLLAP 1695

  Fly   795 ----YKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGM--------QPGLTLVVGPPGTGKTDV-- 845
                :.:...||...|.|:     |...|..||..|:        .|...|:.|||||||:..
Zfish  1696 HVSFFTHSLDGPSDLDAPE-----FNRDQARAIACGIAMIHRKQKTPKFLLIHGPPGTGKSKTIG 1755

  Fly   846 ------------AVQIISNIYHNHPNQRTLIVTHSNQALNQLFEKIMAL-------------DID 885
                        :...:.|::......|.|:...||.|::.|.:|::.:             :..
Zfish  1756 GLLYKLLSSATNSSATVGNLHSKSRRTRVLLCAPSNAAIDSLMKKVILIFKEKCRNINAPQGNCG 1820

  Fly   886 ERHLLRLGHGEEALETEKDYSRYGRVNYVLAKRMDLLSQVQKLQEALGVSGDNAYTCETAGYFYL 950
            :.:|:|||:.....::.|.:|            :|
Zfish  1821 DINLVRLGNERTISKSLKPFS------------LD------------------------------ 1843

  Fly   951 YNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPLFKGANYDELMDIACSNFR 1015
            :...||.::.|..:     |:|..:.:.:.::..                    |.:...|:..:
Zfish  1844 HQTKARAQRAQQTV-----ESDVHRRKEQLDQMI--------------------ENLSHQCAKTQ 1883

  Fly  1016 YISDIF-NELEEFRAFELLRTGLDR-----------SKYLLVKEAKIIAMTCTHA-------ALK 1061
            ..|..| |.||:.:.|...|.||.|           |:.|:::.|.:|..|.:.:       |.:
Zfish  1884 KNSTEFKNLLEQKKQFLKEREGLSRQIKECRGRRQESQALVLQNAHVICCTLSTSGSIVLENAFR 1948

  Fly  1062 RKELVNLGFR-YDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVIKNMAF 1125
            |     ||.. :..::::|::|..|.||.||:|.:.|        ..|::||.:||||.:.:...
Zfish  1949 R-----LGHEPFSCVIIDEASQAKETETLIPMLYRCP--------SVILVGDPNQLPPTVVSQKA 2000

  Fly  1126 QKYSNMEQSLFTRLVRLGVPT-------VDLDGQGRARASICSLYKWRYKKLEDLQHIFERDEYK 1183
            ::: ..:|||..||.:...|:       :.|..|.|....||. :..:|.....|::..|..:.:
Zfish  2001 KEF-GFDQSLMARLCKSLHPSNSKLPPILLLSMQYRMHPDICE-FPSKYIYNSALKNDCETAQKR 2063

  Fly  1184 QANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLL-GYPAAKISILTTYN 1247
            .:.......|::.:|.|.:...|.:       :....:.:..|.:.::|| ...|.::.::|.||
Zfish  2064 CSLSWPFKPYKVFDVMDGRETKERD-------SFINHKEVSLVGLLLKLLCKEQAVRVGVITPYN 2121

  Fly  1248 GQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTK----AVGHLRDVRRLVV 1308
            .|||.|.|.|.....|..|   ..::.|||.:||::.|.|::|.||..    ::|.:.:.:|:.|
Zfish  2122 AQKHRILDAIKTSGINKQL---QVEVDTVDGFQGREMDCIIVSCVRASSEMGSIGFVGNRQRMNV 2183

  Fly  1309 AMSRARLGLYVFGRVSLF---------------KNCL--ELQQTF-----KLLTQRPLKLSLVPE 1351
            .::||:..|::.|.:...               :.|:  .:|:.|     |::.|:|..||....
Zfish  2184 TITRAKFSLFILGHLRTLREQSDWGALIEDAGRRECIINTMQKNFESDVKKIVKQKPNPLSRSLS 2248

  Fly  1352 DKFPTDRLASAAVASQDIKTVENMSEMAQFVYERYMAKMEELKGTLPSEEELEAMRNQLLQEDEE 1416
            .. |.||                                       ||     |:...::....|
Zfish  2249 HP-PIDR---------------------------------------PS-----AVIRPVMHSPVE 2268

  Fly  1417 SVPEASEEPPEKRAAKEEPLSKKKTTEAFKPTPILNEINVDDTEMGQREQIEEEATDQDKTQESA 1481
            :.|.:...|........:|:.:....|..| .|.:|: ...|....:|..|.||.  ||:::...
Zfish  2269 AGPSSVPRPHHDTTQAAQPMPRLIPLECPK-DPRMND-RPSDPRFSERRPIREET--QDRSRRDI 2329

  Fly  1482 PA 1483
            ||
Zfish  2330 PA 2331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	29/153 (19%)
		AAA_11	818..1123	CDD:289831	70/359 (19%)
		AAA_19	821..893	CDD:289986	22/106 (21%)
		DNA2	<1012..1348	CDD:224037	92/389 (24%)
		UvrD_C_2	1131..1321	CDD:304668	49/201 (24%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	71/368 (19%)
		AAA_12	2005..2197	CDD:289832	49/202 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3418
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940