Protein Alignment CG31368 and Helz

DIOPT Version :10

• Sequence 1: NP_996198.2
• Gene: CG31368 / 41437
• FlyBaseID: FBgn0051368
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Alignment Length: 1465
• Identity: 261/1465 - (17%)
• Similarity: 433/1465 - (29%)
• Gaps: 593/1465 - (40%)

  Fly     1 MKRRSQTRAEQ------------AVPPAKTTKENSGSLTVSQLSSDVIWQLASQYWTPD------ 47
            :|:|.|.:.:|            :...:.::.....|.|:|..|:       |.:.|.|
  Fly   196 LKKREQQQQQQQQQQQQNGNGIGSYASSSSSSSTGSSSTMSSSST-------SLHKTNDLLAAMK 253

  Fly    48 -TKADHLPYSAKIIERIYNEEIGDGGGHS-------ARRINMLEFSQYLEQYLWPHYQRETATHA 104
             |...|.|.|            |||.|..       :...:....:......|..|.|    |.|
  Fly   254 LTAGKHQPGS------------GDGSGSDQGDQAAPSTTCSYCTITFQTRNELRQHCQ----TEA 302

  Fly   105 HLMSIVIMANE----KFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASSTLRERTALL 165
            |  ..|||::|    |:|.....:|:     |.|
  Fly   303 H--QKVIMSDEGRDWKWRPPPRGYTL-----DTY------------------------------- 329

  Fly   166 MFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWK-RLLKKEKDSKPEV 229
               :.|....|..:|...|:         |::...::    |:.||::.:: |.::.:|..:.|
  Fly   330 ---SLCETFSEAHICHYGAQ---------CVEAHGQD----ELNEWKERFEYRRMRMQKACEKE- 377

  Fly   230 LWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRRFFNTVLDDCHLI 294
            |:.:.:.:.::..::        :...|..|:  |||    :.|:||....:            :
  Fly   378 LYGKSYTEQVLDRWI--------QATAPERVM--CER----VPDMEARCEQQ------------L 416

  Fly   295 VRALLSPLVRREEGKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKKITSLQRAVFAKFP 359
            |.::.|...:||  .||                             ||..||  .|:.....:..
  Fly   417 VTSISSKTSKRE--WLF-----------------------------QLETKK--PLKAVALLQDA 448

  Fly   360 SLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVPEEVVSPLDW-------------- 410
            ....|||.::......||                       ..|:.|..:|
  Fly   449 HRNHFALKSIKMCKPTES-----------------------SMELKSDQEWLAGSSSQSETSNED 490

  Fly   411 -----HRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKL 470
                 |.:..:|..|:..|..:..|..:                           |...|.:..|
  Fly   491 SATLIHEITVEFHTEIYGTFRQAICFDV---------------------------GQEPLLVRHL 528

  Fly   471 NLQFLTLHDYLLRNFNLFRLESTYEIRQDI------------------EDAVSRMLPWKSEDGDV 517
            .:..|.::|          .|...||::||                  |..:...|..::...|:
  Fly   529 CVDVLPVND----------AEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDL 583

  Fly   518 VFGGWARMALPIASFAVVEVAKPHLGEKK--PSRVRADVGVTLSVRREIKAEWENLRKHDVCFLI 580
            ..........|....|...:.:..:.||:  .:..|:.:...||| .|| |.:|.:.:::|...:
  Fly   584 EHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSV-EEI-ARYEQIARYNVRTRL 646

  Fly   581 TVKPT---QPYG-----TKYKHREPFVPQVGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGEN 637
            ||...   .|.|     .||             |:.| |:..::.....:.||....|..|   :
  Fly   647 TVASNYILTPAGMATSTAKY-------------SLAG-ELFALMRLGKDISEDTSPGRLIL---S 694

  Fly   638 RCYRVWLDSNQYRLDMDDLQEGADD----VYESFNILMRRKPKENNFKAVLETIRHLMNTECVVP 698
            .|..|::..      .:|....||.    |||:   |:..|.|        ..|...::.:||
  Fly   695 NCSSVYISK------PEDPDSKADPTKRAVYEA---LIEDKGK--------NVIYLKLSAKCV-- 740

  Fly   699 PWLHDILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEVPVE---NRQP-- 758
                                                    ||...|.:.:.||.::   ||.|
  Fly   741 ----------------------------------------EAMALQADTELEVDIQFQLNRMPYC 765

  Fly   759 ----------PFRLIFEDVPIQKESDGEDPEEKPEEKLTKSILVQPYKYEARGPYPSDKPKQNSI 813
                      .|||||                 |..:|..||...|.|..|    .|.:||.|:
  Fly   766 EWHNAVDKITDFRLIF-----------------PATELEPSIPWTPKKQWA----DSCEPKLNA- 808

  Fly   814 RFTPTQVEAIRA-------GMQPGLTLVVGPPGTGKTDVAVQIISNIYHNHPNQRTLIVTHSNQA 871
                .|.||:.|       .:.|  .|::||.|||||....|.|..:. ..|..:.||.||||.|
  Fly   809 ----KQREAVNAITTALSIKLPP--ILLIGPFGTGKTYTLAQAIKQLL-TQPEAKILICTHSNSA 866

  Fly   872 LNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAKRMDLLSQVQKLQEALGVSG 936
            .:
  Fly   867 AD--------------------------------------------------------------- 868

  Fly   937 DNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPLFKGA 1001
                       .|:...:..|        :.:|..:|..||..:.|.:               .|
  Fly   869 -----------LYIKEYLHPW--------IEEGLKEATPLRVYYHKRW---------------SA 899

  Fly  1002 NYDELMDIAC-----SNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKEAKIIAMTCTHAALK 1061
            ..:.::...|     .||                 |..|..|..::.:|.....|:|
  Fly   900 TVNGVVQKYCITDGVGNF-----------------LRPTVEDIMRHRIVVVTLSISM-------- 939

  Fly  1062 RKELVNLGF---RYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVIKNM 1123
              ||..||.   .:.:|.::|:||.:|.|..:||.|.|.      ..|.::.|||.|:.|.:.:
  Fly   940 --ELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALAND------STRIVLAGDHMQMSPELFS- 995

  Fly  1124 AFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQHIFERDEYKQANPG 1188
            ||.|...:..||..||..      ........:..:|..|:.....:.....:|...:...:...
  Fly   996 AFAKERKLHISLLERLYD------HYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQ 1054

  Fly  1189 FVHD-YQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAA-------KISILTT 1245
            ..|| :..:.....:|....:.|...:.|.||...:|.....:| ..:|:|       .|.|:|.
  Fly  1055 PRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELR-KRWPSAWGKLNDTSIGIMTP 1118

  Fly  1246 YNGQKHLIR-DVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAV------------ 1297
            |:.|...|| ::...|.|.       ..:..|...||:|...:.:|.|||:..
  Fly  1119 YSDQVFRIRSELRKRRMGG-------ISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSAS 1176

  Fly  1298 -----------GHLRDVRRLVVAMSRARLGLYVFG 1321
                       |.|.:.:.|..|::||:..:.|.|
  Fly  1177 TTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVG 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:435319	147/866 (17%)
		EEXXQc_AQR	810..1168	CDD:350693	70/372 (19%)
		SF1_C_Upf1	1156..1339	CDD:350195	39/198 (20%)
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	6/66 (9%)
		DEXXQc_HELZ	805..1030	CDD:350835	70/369 (19%)
		DNA2	<925..1236	CDD:440729	69/318 (22%)