DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31368 and CG7504

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster

Alignment Length:	963	Identity:	197/963 - (20%)
Similarity:	340/963 - (35%)	Gaps:	285/963 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 GGWARMAL--PIASFAVVEVAKPHLGEKKPSRVRADVGVTLSVRREI-----------------K 565
            ||:....:  |....|..:.|||  ..|||...:.....|.|.:.:.                 :
  Fly   813 GGFLTKGVDGPAPKLAKTDNAKP--PPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCSRPVER 875

  Fly   566 AEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQVGLVSVRGCEVEGMLDANGRVIEDGPEPR 630
            .|.|..|....|..:|....:.|..|.:..:....::..|....       |.....||......
  Fly   876 KEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFND-------DVKVHCIERVKGAS 933

  Fly   631 PQLQGENRCYRVWLDSNQYRLD--------MDD---------------LQEGADDVYESFNILMR 672
            .::||...|.::.|.|.:.|.:        ::|               |:.|:.|.....::||.
  Fly   934 SKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMP 998

  Fly   673 RKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQE---------RSLEF 728
            ..|:.::||...|....||..| ::.....|..:...:..:....|:..|:         .|..|
  Fly   999 IPPEFDSFKNYREIFVPLMKLE-LLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPF 1062

  Fly   729 --------------NDTFMDYNHLEASFPQYNLKCEVPVENRQPPFRLIFEDVPIQKESDGEDPE 779
                          .:||.  |.||..|...|:            |.|.||   |.|:...|:..
  Fly  1063 GKFVLYTLYCCGMLKETFA--NLLELKFVSGNV------------FDLTFE---ILKQDISEEKL 1110

  Fly   780 E-------------------------------------KPEEKLTK-SILVQPYKYEARGPYPSD 806
            :                                     ||.:.:.: |:..||:.:  :|.:..:
  Fly  1111 KNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTF--KGCHKLN 1173

  Fly   807 KPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQI-ISNIYHNHP---NQRTLIVTH 867
            :.::|.:..|   .:.|...:||.|||:.|||||||:.|..:: :..:|.|..   :::.||..|
  Fly  1174 EHQENIVLHT---YQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAH 1235

  Fly   868 SNQALNQ----LFEKIMALDIDERHLLRLGHGEE--------ALET------EKDYSRYGRVNYV 914
            ||.|::.    |...:..::.|:.||||.|..|:        :||.      |:...|..:.|..
  Fly  1236 SNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAE 1300

  Fly   915 LAKRM--DLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLR 977
            :.|:.  ||..::|:|:|...::..           ||...:.:.||....||
  Fly  1301 ILKKQHNDLKDEIQQLKEKTNLTST-----------YLLQQLQQKEKKLQLIS------------ 1342

  Fly   978 AEFEKEFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKY 1042
                                                 ..:|....:.|||..           .:
  Fly  1343 -------------------------------------NQLSPPLTQREEFEI-----------SH 1359

  Fly  1043 LLVKEAKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRW 1107
            :.|..|.||..|.:...    :|.|....:|..:::|:.|..|..|.:|:..     ||..:
  Fly  1360 MCVTRANIICTTLSSCV----KLANYVDFFDICIVDEATQCTEPWTLLPMRF-----GLTHM--- 1412

  Fly  1108 IMIGDHHQLPPVIKN-------MAFQKYSNMEQSLFTRLVRLG------VPTVDLDGQGRARASI 1159
            :::||..|||.|:.:       ::...:..:::||.|:|.:.|      .....|..|.|....|
  Fly  1413 VLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEI 1477

  Fly  1160 CSLYKWRYKKLEDLQHIFERDEYKQANPGFVHDYQLINVE---DFKGVGESEPNPYFYQNLAEAE 1221
            |   :|..:...:.|.|......:.|:|  :..|.:||::   |..|.....     ..|..||.
  Fly  1478 C---RWPNQYFYEDQLINAECTARFASP--LIPYCVINLKYTCDSNGAQNKS-----ISNNEEAR 1532

  Fly  1222 YIVAVYMYMRLLGYPAAKIS--ILTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQN 1284
            ::..:...|. ...|:.:.|  :::.|..|.:.:..||.:.....|        .|||.|||.:.
  Fly  1533 FVAKLLTEMD-KHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITP--------QTVDSYQGLEK 1588

  Fly  1285 DYILISLVRTKAVGHLRDVRRLVVAMSRARLGLYVFGR------VSLFKNCLE 1331
            |.|:||..||:..|.|.:.:||.||::|.|..|.:.|.      |.:::|.|:
  Fly  1589 DVIIISNARTRGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLD 1641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	68/397 (17%)
		AAA_11	818..1123	CDD:289831	72/335 (21%)
		AAA_19	821..893	CDD:289986	28/79 (35%)
		DNA2	<1012..1348	CDD:224037	81/344 (24%)
		UvrD_C_2	1131..1321	CDD:304668	52/200 (26%)
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	74/342 (22%)
		AAA_19	1194..1251	CDD:289986	20/56 (36%)
		YtxH	<1293..1347	CDD:295162	14/113 (12%)
		AAA_12	1435..1626	CDD:289832	52/209 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940