DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31368 and cwf11

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_595360.1	Gene:	cwf11 / 2541124	PomBaseID:	SPBC646.02	Length:	1284	Species:	Schizosaccharomyces pombe

Alignment Length:	1375	Identity:	336/1375 - (24%)
Similarity:	589/1375 - (42%)	Gaps:	217/1375 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 INMLEFSQYLEQYLWPHYQRE-TATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVL 142
            :::|...:..|.:||.....| :..|.:|..::::...|: |.: .|.:.::  :::..||..|:
pombe    49 LSLLHELKLFENFLWQRVNTEMSLNHINLTCMLLLYKSKY-EYI-TWDLIDE--NRFQLFFEKVI 109

  Fly   143 ESCLPSKKAKEASSTLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELRE 207
            |..|        |..|.|...::.||..||....||..|:...:|.::|:.:.|      ..|.:
pombe   110 EVSL--------SLNLSEVVYMIQFITLCFQFSNIEKLRKLVYQLTNISILNSL------DNLDK 160

  Fly   208 VPEWRKY-------WKRLLKKEKDSKPEVLWERHFMQNLIIDFLH--ILESIP-AEGEVPRNVVH 262
            |    ||       ..:.....|:.:|.:: |:..:.||:..::|  :::||. |:.|.....|.
pombe   161 V----KYLLHDSSSLTKAFDSYKEKRPSIV-EKFPLHNLLSRWIHSLLIKSISYAQTEKQEAKVT 220

  Fly   263 YCERFLEFIIDLEALLPTRRFFNTVLDDCHLIVRALLSPLVRREEGKLFGQLLDMLKFYTRFEIN 327
            .....:...:.|.:..|||||.:.|::|........:|  :..:..:||.::.|.|.:..:|..:
pombe   221 PLLAIINMSLVLLSAFPTRRFAHPVIEDSCFYTALRMS--LYYDSNELFKKMTDDLNYVLKFPFD 283

  Fly   328 DVTGS------SLTDHDMTQLHYKKITSLQRAVFAKF-PSLRVFALSNVATVDNRESLEQ----- 380
            :..|:      .:.:.::...|      ||..:|:.| ..|.........::..|:.||:
pombe   284 NTRGNEYEKEQKIRNDELVYYH------LQLTLFSDFQKELGDLVFCTQTSLQQRQKLEEITSFL 342

  Fly   381 HFGGLDGKGLLQIATFLNLVPEEVVSPLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTE 445
            .|..|  |.|..........||:...     :||.:||:.:.|..:: |...:...:|:..:..:
pombe   343 SFNSL--KSLCSKCYLRTSFPEKYAI-----KVDFEFLKNVFINTYD-RTRLVNDYDEIINFTLK 399

  Fly   446 QIIWDENVVPSEYYSGDSCLALPKLNLQFLTLHDYLLRNFNLFR---LESTY-EI--------RQ 498
            .::.:.:|:..| .|..:...|....:|:|::..::.:....::   |.|.| |:        |.
pombe   400 DVLGERSVMDQE-NSLTNYFLLQNTAIQYLSISFFMRQQSKAYKKLLLRSLYAELLNFSEQYRRL 463

  Fly   499 DIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVEVAKPHLGEKKPSRVRADVGVTL----- 558
            .|::|.      |:...|..|.        :.:|.|..||.|.:|:..|..|:..:|::.
pombe   464 SIKNAT------KNLTKDNFFS--------LNNFKVTSVAPPQIGQVLPQFVKCQMGLSRPGPFH 514

  Fly   559 SVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQVG-----LVSVRGCEVEGMLDA 618
            |..|::|   .:::...:| ||.:.....|  |..|.....|..|     :.::...:| ||..:
pombe   515 SALRDLK---NSIKSPFLC-LIYISKDMEY--KLLHGNALDPLEGVTDFTIATICNDDV-GMFQS 572

  Fly   619 NGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDMDDLQEGADDVYE----SFNILMRRKPKENN 679
            :           .|...:|:...|:|....|. .:..|.|     |.    .||..:...|:.|.
pombe   573 D-----------MQSDSDNKSINVYLSPFYYH-SLAGLGE-----YRPKQLKFNFALVLSPEANK 620

  Fly   680 FKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQE-RSLEFNDTFMDYNHLEASFP 743
            :...|..:..|:|.....|.|..|:.||:|.|....:   ||.. .|:...:.|.....|::..|
pombe   621 YWLDLNILVSLLNRAKEFPKWFEDLFLGFGTPDICAF---PNAGLNSIYARNLFNTVEQLQSVLP 682

  Fly   744 QYNLKCEVPVENRQPPFRLIFEDVPIQKESDGEDPEEKPEEKLTKSILVQPYKYE---ARGPYPS 805
                .|.|                              |....|:|:|::.|..:   :.....|
pombe   683 ----NCHV------------------------------PSNLSTESLLIKFYTNQNKISADVTAS 713

  Fly   806 DK----PKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNHPNQRTLIVT 866
            |:    |......:...|:|:|..|.|||||:|.||...||..:..:::..:....||.||::::
pombe   714 DRHFLLPSNRLYTYNDKQLESILRGSQPGLTMVNGPTRCGKHVLVCKLLEVLQDTSPNDRTVVLS 778

  Fly   867 HSNQALNQLF---EKIMALDIDERHLLRLGH--GEEALETEKDYSRYGRVNYVLAKRMDLLSQVQ 926
            .||.::|.||   ||  |....:.|||.|..  .:|.||      |||.::..::|...||.::.
pombe   779 DSNFSMNTLFTLLEK--ARCFHQGHLLYLSDEGKDETLE------RYGTLSSWISKLPGLLREIG 835

  Fly   927 KLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFA 991
            :|..::...|.:..:.:||.||....:...|||:.:.:. .|...||       ...|||..:|.
pombe   836 RLAASIQAPGSHDASPDTALYFRDAYIKRLWEKYLNTVD-DKDSVDA-------YNRFPFHSYFG 892

  Fly   992 DAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKEAKIIAMTCT 1056
            |..:...:..|.|...|.|...:..:..:|.:|||.|.|.|||...|:..|.|.::::||..|.|
pombe   893 DKSKRPIETYNKDNFFDYATKLYGELEYMFQQLEEIRPFGLLRYYEDQELYALCQQSRIIGCTWT 957

  Fly  1057 HAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQN--PLDGLNRLKRWIMIGDHHQLPPV 1119
            ..:.:...|...||.::|:::..|..|.| .:...:||.|  | .|.:||   :::|:.:.   .
pombe   958 SLSTRLGTLKEKGFCFNNLIVMNSQNISE-SSITSILLSNCEP-TGFDRL---VLLGNQYL---T 1014

  Fly  1120 IKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSL----YKWRYKKLEDLQHIFERD 1180
            ..|......||  .|||.||..|....:||:.|...|.||.||    |....|.::...:  :|.
pombe  1015 SGNQDINNTSN--GSLFKRLRYLKSRIIDLNTQYNVRESISSLCSSIYPLDIKTVDSSPN--KRL 1075

  Fly  1181 EYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKISILTT 1245
            :|  .|.||.|:.|.|||..|||..|:||...:.|||.||||.||::.|||:||||..:|.|.|.
pombe  1076 DY--GNSGFAHEVQFINVGAFKGSQETEPVSGYKQNLGEAEYAVALFQYMRMLGYPTNEIVICTL 1138

  Fly  1246 YNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQN-DYILISLVRTKAVGHLRDVRRLVVA 1309
            |..|..|:.::|:.||.:|...|.|..:.||:|....:. ::::.:.|.:|......:.:....|
pombe  1139 YESQVSLLNEIISVRCSHNSFFGQPAFVGTVEKLPSDKRVNFVIFTTVESKEASDHWNPKTFYKA 1203

  Fly  1310 MSRARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIKTVEN 1374
            .|....||||.....||::...|::.:..:.:.|.||.|...:.:|:.....::|.:.:|   ||
pombe  1204 FSACSYGLYVLCNRDLFRSTRGLEKLWNEIEKTPDKLLLTTGEIYPSSHKIGSSVETFEI---EN 1265

  Fly  1375 MSEMAQFVYE 1384
            :..::.:|.|
pombe  1266 LLHLSNYVVE 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	157/792 (20%)
		AAA_11	818..1123	CDD:289831	91/311 (29%)
		AAA_19	821..893	CDD:289986	28/74 (38%)
		DNA2	<1012..1348	CDD:224037	111/342 (32%)
		UvrD_C_2	1131..1321	CDD:304668	71/194 (37%)
cwf11	NP_595360.1	Aquarius_N	49..>526	CDD:293008	108/533 (20%)
		TIGR00376	<728..1153	CDD:273041	149/454 (33%)
		UvrD_C_2	1027..1193	CDD:304668	65/169 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1523
eggNOG	1	0.900	-	-		E1_KOG1806
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I629
OMA	1	1.010	-	-		QHG55102
OrthoFinder	1	1.000	-	-		FOG0005435
OrthoInspector	1	1.000	-	-		oto101141
orthoMCL	1	0.900	-	-		OOG6_102954
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3418
SonicParanoid	1	1.000	-	-		X3849
TreeFam	0	0.000	Not matched by this tool.
	12	11.900