DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31368 and SETX

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001338457.1	Gene:	SETX / 23064	HGNCID:	445	Length:	2706	Species:	Homo sapiens

Alignment Length:	877	Identity:	173/877 - (19%)
Similarity:	327/877 - (37%)	Gaps:	307/877 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 QEGADDVYESFNILMRRKPKENN------------FKAVLETIRHLMNTECV-------VPPWLH 702
            |:...::..|.|:|..:.|..:|            :......:..|::::.|       |..|.:
Human  1646 QKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYFPSSSPVNILLSSQSVSDTFVKEVLKWKY 1710

  Fly   703 DILLGYGDPG---------------------------------------AAHYSNMPNQER--SL 726
            ::.|.:|..|                                       |..:.|.||:|.  .|
Human  1711 EMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQL 1775

  Fly   727 EFNDTFMDY-NHLEASFPQYNLKCEV-----PVENR---QPPFRLIFEDVPIQKESDGEDPEEKP 782
            :......|| .:.|  |..|..:||:     |.||.   ..|.|:..|    :|:::..|.::..
Human  1776 QVRKFPADYIKYWE--FAVYLEECELAKQLYPKENDLVFLAPERINEE----KKDTERNDIQDLH 1834

  Fly   783 E------EKLTKSILVQPYKYEARGPYPSDKPKQN---------------SIRFTPTQVEAI--- 823
            |      .|..::.:::..|.|.   |.|.:.::|               |:..|..:::|:
Human  1835 EYHSGYVHKFRRTSVMRNGKTEC---YLSIQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLL 1896

  Fly   824 -------RAGMQPG-----------------------------------------------LTLV 834
                   ||.:.|.                                               :.|:
Human  1897 GSRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLI 1961

  Fly   835 VGPPGTGKTDVAVQIISNIY-------HNHPN-------QRTLIVTHSNQALNQLFEKIMALDID 885
            .|||||||:...|.::..:.       |:..|       .|.|:...||.|:::|.:||: |:..
Human  1962 HGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKII-LEFK 2025

  Fly   886 ER--------------HLLRLGHGEEALETE-KDYSRYGRVNYVLAKRMDLLSQVQ---KLQEAL 932
            |:              :|:||| .|:::.:| ..:|...:||:.:.|  :|.|.||   |.:|.|
Human  2026 EKCKDKKNPLGNCGDINLVRLG-PEKSINSEVLKFSLDSQVNHRMKK--ELPSHVQAMHKRKEFL 2087

  Fly   933 GVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPL 997
            .               |..:.::|      |.::.:|..:.:  |.|.::.
Human  2088 D---------------YQLDELSR------QRALCRGGREIQ--RQELDEN-------------- 2115

  Fly   998 FKGANYDELMDIACSNFRYISDIFNELEEFRA-FELLRTGLDRSKYLLVKEAKIIAMT-CTHAAL 1060
                               ||.:..|.:|..: .:.::....:::.:::.|:.||..| .|...|
Human  2116 -------------------ISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGGL 2161

  Fly  1061 KRKELVNLGFR------YDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPV 1119
                |:...||      :..::::|:.|..||||..||        ::|..:.|::||..||||.
Human  2162 ----LLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPL--------IHRCNKLILVGDPKQLPPT 2214

  Fly  1120 IKNMAFQKYSNMEQSLFTRLVRL-----------GVPTVDLDGQGRARASICSLYKWRYKKLEDL 1173
            :.:|..|:| ..:||:..|..||           .:|.:.|..|.|....|| |:...|....:|
Human  2215 VISMKAQEY-GYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDIC-LFPSNYVYNRNL 2277

  Fly  1174 QHIFERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLL----- 1233
            :...:.:..:.::......|.:.:|.|    |....:...|.|:.|.:.::.:   ::|:
Human  2278 KTNRQTEAIRCSSDWPFQPYLVFDVGD----GSERRDNDSYINVQEIKLVMEI---IKLIKDKRK 2335

  Fly  1234 GYPAAKISILTTYNGQKHLIRDVINA---RCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTK 1295
            ......|.|:|.|..||.:|:..::.   |.|       |.::.|||.:||:|.|.::::.||..
Human  2336 DVSFRNIGIITHYKAQKTMIQKDLDKEFDRKG-------PAEVDTVDAFQGRQKDCVIVTCVRAN 2393

  Fly  1296 ----AVGHLRDVRRLVVAMSRARLGLYVFGRV 1323
                ::|.|..::||.|.::||:..|::.|.:
Human  2394 SIQGSIGFLASLQRLNVTITRAKYSLFILGHL 2425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	42/247 (17%)
		AAA_11	818..1123	CDD:289831	77/401 (19%)
		AAA_19	821..893	CDD:289986	27/156 (17%)
		DNA2	<1012..1348	CDD:224037	82/343 (24%)
		UvrD_C_2	1131..1321	CDD:304668	49/212 (23%)
SETX	NP_001338457.1	SEN1_N	37..>351	CDD:315409
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1237..1258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1604
		AAA_11	1933..2218	CDD:315699	73/356 (21%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2070..2087		7/18 (39%)
		AAA_12	2225..2424	CDD:315700	49/213 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2503..2525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2585..2606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2626..2706
		Necessary for nuclear localization	2690..2706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3418
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940