Protein Alignment CG31368 and Aqr

DIOPT Version :10

• Sequence 1: NP_996198.2
• Gene: CG31368 / 41437
• FlyBaseID: FBgn0051368
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_033832.2
• Gene: Aqr / 11834
• MGIID: 1276102
• Length: 1481
• Species: Mus musculus
• Alignment Length: 1504
• Identity: 925/1504 - (61%)
• Similarity: 1132/1504 - (75%)
• Gaps: 84/1504 - (5%)

  Fly    27 TVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQY 91
            ||||::::.:.|||.:||.|..|... |:..|:||.||.:||.. ...:.|:|.:||||||||.|
Mouse    14 TVSQINAEFVTQLACKYWAPHIKKKS-PFDIKVIEEIYEKEIVK-SRFAIRKIMLLEFSQYLENY 76

  Fly    92 LWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASS 156
            ||.:|..|.::.|:||||..|.||||||.|..|..|:|.||.:|.||:.:|::.|..   .:...
Mouse    77 LWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAE---TDGEF 138

  Fly   157 TLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWKRLLKK 221
            :|.|:|.||:|::|||||:|::|.|.|.::|:||.||..|||.|.|.||::.|:.||:|..:.|.
Mouse   139 SLHEQTLLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKN 203

  Fly   222 EKDSKPE----VLWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRR 282
            ::...||    ...||.|:..||..|:.:|:|||....|..:.|||||||:|.:|||||||||||
Mouse   204 DEKMDPEAREQAYQERRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRR 268

  Fly   283 FFNTVLDDCHLIVRALLSPLVRREE-GKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKK 346
            :|||:|||.||:|...||.||.||| |.||.||||||||||.|||||.||::||:::||.:||.:
Mouse   269 WFNTILDDSHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDR 333

  Fly   347 ITSLQRAVFAKFPSLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVP-----EEVVS 406
            |||||||.||.||.|..|||||||.||.|:||.:.||.|....|.|:|::|.|:|     |:..
Mouse   334 ITSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTT- 397

  Fly   407 PLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKLN 471
                  .|::||.|||::|||||.||::.||:|||||||:||||||:||:|||||:.||||||||
Mouse   398 ------FDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLN 456

  Fly   472 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVE 536
            |||||||||||||||||||||||||||||||:||||.||:||.|.||||||||||.||.:|.|||
Mouse   457 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVE 521

  Fly   537 VAKPHLGEKKPSRVRADVGVTLSVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQ 601
            ||||::||..|:||||||.:.|:||..||.|||.||||||||||||:||:|||||:..|.||:.|
Mouse   522 VAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQ 586

  Fly   602 VGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDM-DDLQEGADDVYE 665
            ||||.|||||::||||..||||||||||||.|:||:|.:||:||.|||:.|| :.:|.||:|||:
Mouse   587 VGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYD 651

  Fly   666 SFNILMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFND 730
            :||::||||||||||||||||||:||||:||||.|||||:||||||.:||||.||||..:|:|||
Mouse   652 TFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFND 716

  Fly   731 TFMDYNHLEASFPQYNLKCEVPVENRQ-PPFRLIFEDVPI-------QKESDGEDPEEKPEEKLT 787
            ||:...||:||||.:|:|..|.....| ||||:.|   |:       :|::|||  |:..||  .
Mouse   717 TFLSIEHLKASFPGHNVKVTVSDPALQIPPFRITF---PVRSGKGKKRKDADGE--EDDTEE--A 774

  Fly   788 KSILVQPYKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISN 852
            |:::|:|:....|||||.::||:|:|:||.||:||||||||||||:|||||||||||||||||||
Mouse   775 KTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISN 839

  Fly   853 IYHNHPNQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAK 917
            ||||.|.||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||:
Mouse   840 IYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLAR 904

  Fly   918 RMDLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEA--DAEKLRAEF 980
            |::||.:|::||::|||.||.:|||||||||:||.||:|||::.|::. :.|.|  ||....|:.
Mouse   905 RIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVK-NSGTACPDAAPDAAQV 968

  Fly   981 EKEFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLV 1045
            ...|||.::||:||||:|||.:|:|.|:||...||:|..||.:||||||.||||:||||||||||
Mouse   969 ATFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLV 1033

  Fly  1046 KEAKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMI 1110
            |||||||||||||||||.:||.|||:||||||||:|||||||||||||||||.||.:||||||||
Mouse  1034 KEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMI 1098

  Fly  1111 GDHHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQH 1175
            ||||||||||||||||||||||||||||.||:||||||||.|||||||:|:||.||||.|.:|.|
Mouse  1099 GDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPH 1163

  Fly  1176 IFERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKI 1240
            :....|:..||.|.::|:||||||||:|||||||||||||||.||||:||::|||.||||||.||
Mouse  1164 VQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKI 1228

  Fly  1241 SILTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRR 1305
            |||||||||||||||:||.|||||||||.|:|:||||::|||||||||:|||||:||||||||||
Mouse  1229 SILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRR 1293

  Fly  1306 LVVAMSRARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIK 1370
            |||||||||||||:|.|||||:||.||...|..||.|||.|.::|.:.|||.| .:......:::
Mouse  1294 LVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSR-KNGERPPHEVQ 1357

  Fly  1371 TVENMSEMAQFVYERYM------------------AKMEELKGTLPSEEELEAMRNQLLQEDEES 1417
            .::||.:||.|||..||                  |.:||.:.....|.|:||        :||:
Mouse  1358 VIKNMPQMANFVYNMYMHLIQTTHHYHQTFLQLPPAMVEEGEEGQSQETEMEA--------EEET 1414

  Fly  1418 VP---EASEEPPEKRAAKEEPLSK----KKTTEAFKPTPILNEINVDDTEMGQREQIEEEATDQD 1475
            |.   ..:..|.:...::|.|.::    .:|.:...|..|.       |.........|.||.||
Mouse  1415 VSAQGNLTPSPADASLSQETPAAQPDCSSQTEDTSAPCDIA-------TAAEPVSAAAEAATPQD 1472

  Fly  1476 KTQESAPAE 1484
              .||.|.|
Mouse  1473 --AESVPTE 1479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:435319	468/800 (59%)
		EEXXQc_AQR	810..1168	CDD:350693	279/359 (78%)
		SF1_C_Upf1	1156..1339	CDD:350195	138/182 (76%)
Aqr	NP_033832.2	Helical region with structural similarity to ARM repeat domains. /evidence=ECO:0000250|UniProtKB:O60306	1..416		208/413 (50%)
		Aquarius_N	18..802	CDD:435319	468/802 (58%)
		Required for assembly of the IB complex. /evidence=ECO:0000250|UniProtKB:O60306	417..1481		716/1089 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..773		5/20 (25%)
		EEXXQc_AQR	797..1156	CDD:350693	279/359 (78%)
		SF1_C_Upf1	1144..1327	CDD:350195	138/182 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1396..1481		25/101 (25%)