DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31368 and Aqr

DIOPT Version :9

Sequence 1:	NP_996198.2	Gene:	CG31368 / 41437	FlyBaseID:	FBgn0051368	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_033832.2	Gene:	Aqr / 11834	MGIID:	1276102	Length:	1481	Species:	Mus musculus

Alignment Length:	1504	Identity:	925/1504 - (61%)
Similarity:	1132/1504 - (75%)	Gaps:	84/1504 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQY 91
            ||||::::.:.|||.:||.|..|... |:..|:||.||.:||.. ...:.|:|.:||||||||.|
Mouse    14 TVSQINAEFVTQLACKYWAPHIKKKS-PFDIKVIEEIYEKEIVK-SRFAIRKIMLLEFSQYLENY 76

  Fly    92 LWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASS 156
            ||.:|..|.::.|:||||..|.||||||.|..|..|:|.||.:|.||:.:|::.|..   .:...
Mouse    77 LWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAE---TDGEF 138

  Fly   157 TLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWKRLLKK 221
            :|.|:|.||:|::|||||:|::|.|.|.::|:||.||..|||.|.|.||::.|:.||:|..:.|.
Mouse   139 SLHEQTLLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKN 203

  Fly   222 EKDSKPE----VLWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRR 282
            ::...||    ...||.|:..||..|:.:|:|||....|..:.|||||||:|.:|||||||||||
Mouse   204 DEKMDPEAREQAYQERRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRR 268

  Fly   283 FFNTVLDDCHLIVRALLSPLVRREE-GKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKK 346
            :|||:|||.||:|...||.||.||| |.||.||||||||||.|||||.||::||:::||.:||.:
Mouse   269 WFNTILDDSHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDR 333

  Fly   347 ITSLQRAVFAKFPSLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVP-----EEVVS 406
            |||||||.||.||.|..|||||||.||.|:||.:.||.|....|.|:|::|.|:|     |:..
Mouse   334 ITSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTT- 397

  Fly   407 PLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKLN 471
                  .|::||.|||::|||||.||::.||:|||||||:||||||:||:|||||:.||||||||
Mouse   398 ------FDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLN 456

  Fly   472 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVE 536
            |||||||||||||||||||||||||||||||:||||.||:||.|.||||||||||.||.:|.|||
Mouse   457 LQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVE 521

  Fly   537 VAKPHLGEKKPSRVRADVGVTLSVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQ 601
            ||||::||..|:||||||.:.|:||..||.|||.||||||||||||:||:|||||:..|.||:.|
Mouse   522 VAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQ 586

  Fly   602 VGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDM-DDLQEGADDVYE 665
            ||||.|||||::||||..||||||||||||.|:||:|.:||:||.|||:.|| :.:|.||:|||:
Mouse   587 VGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYD 651

  Fly   666 SFNILMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFND 730
            :||::||||||||||||||||||:||||:||||.|||||:||||||.:||||.||||..:|:|||
Mouse   652 TFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFND 716

  Fly   731 TFMDYNHLEASFPQYNLKCEVPVENRQ-PPFRLIFEDVPI-------QKESDGEDPEEKPEEKLT 787
            ||:...||:||||.:|:|..|.....| ||||:.|   |:       :|::|||  |:..||  .
Mouse   717 TFLSIEHLKASFPGHNVKVTVSDPALQIPPFRITF---PVRSGKGKKRKDADGE--EDDTEE--A 774

  Fly   788 KSILVQPYKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISN 852
            |:::|:|:....|||||.::||:|:|:||.||:||||||||||||:|||||||||||||||||||
Mouse   775 KTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISN 839

  Fly   853 IYHNHPNQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAK 917
            ||||.|.||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||:
Mouse   840 IYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLAR 904

  Fly   918 RMDLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEA--DAEKLRAEF 980
            |::||.:|::||::|||.||.:|||||||||:||.||:|||::.|::. :.|.|  ||....|:.
Mouse   905 RIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVK-NSGTACPDAAPDAAQV 968

  Fly   981 EKEFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLV 1045
            ...|||.::||:||||:|||.:|:|.|:||...||:|..||.:||||||.||||:||||||||||
Mouse   969 ATFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLV 1033

  Fly  1046 KEAKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMI 1110
            |||||||||||||||||.:||.|||:||||||||:|||||||||||||||||.||.:||||||||
Mouse  1034 KEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMI 1098

  Fly  1111 GDHHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQH 1175
            ||||||||||||||||||||||||||||.||:||||||||.|||||||:|:||.||||.|.:|.|
Mouse  1099 GDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPH 1163

  Fly  1176 IFERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKI 1240
            :....|:..||.|.::|:||||||||:|||||||||||||||.||||:||::|||.||||||.||
Mouse  1164 VQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKI 1228

  Fly  1241 SILTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRR 1305
            |||||||||||||||:||.|||||||||.|:|:||||::|||||||||:|||||:||||||||||
Mouse  1229 SILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRR 1293

  Fly  1306 LVVAMSRARLGLYVFGRVSLFKNCLELQQTFKLLTQRPLKLSLVPEDKFPTDRLASAAVASQDIK 1370
            |||||||||||||:|.|||||:||.||...|..||.|||.|.::|.:.|||.| .:......:::
Mouse  1294 LVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSR-KNGERPPHEVQ 1357

  Fly  1371 TVENMSEMAQFVYERYM------------------AKMEELKGTLPSEEELEAMRNQLLQEDEES 1417
            .::||.:||.|||..||                  |.:||.:.....|.|:||        :||:
Mouse  1358 VIKNMPQMANFVYNMYMHLIQTTHHYHQTFLQLPPAMVEEGEEGQSQETEMEA--------EEET 1414

  Fly  1418 VP---EASEEPPEKRAAKEEPLSK----KKTTEAFKPTPILNEINVDDTEMGQREQIEEEATDQD 1475
            |.   ..:..|.:...::|.|.::    .:|.:...|..|.       |.........|.||.||
Mouse  1415 VSAQGNLTPSPADASLSQETPAAQPDCSSQTEDTSAPCDIA-------TAAEPVSAAAEAATPQD 1472

  Fly  1476 KTQESAPAE 1484
              .||.|.|
Mouse  1473 --AESVPTE 1479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31368	NP_996198.2	Aquarius_N	33..815	CDD:293008	468/800 (59%)
		AAA_11	818..1123	CDD:289831	236/306 (77%)
		AAA_19	821..893	CDD:289986	68/71 (96%)
		DNA2	<1012..1348	CDD:224037	268/335 (80%)
		UvrD_C_2	1131..1321	CDD:304668	149/189 (79%)
Aqr	NP_033832.2	Helical region with structural similarity to ARM repeat domains. /evidence=ECO:0000250\|UniProtKB:O60306	1..416		208/413 (50%)
		Aquarius_N	18..802	CDD:293008	468/802 (58%)
		Required for assembly of the IB complex. /evidence=ECO:0000250\|UniProtKB:O60306	417..1481		716/1089 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..773		5/20 (25%)
		AAA_11	805..1111	CDD:289831	236/306 (77%)
		AAA_19	808..880	CDD:289986	68/71 (96%)
		UvrD_C_2	1119..1308	CDD:304668	149/188 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1481		25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842763
Domainoid	1	1.000	922	1.000	Domainoid score	I42
eggNOG	1	0.900	-	-		E1_KOG1806
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7629
Inparanoid	1	1.050	1785	1.000	Inparanoid score	I66
Isobase	1	0.950	-	0	Normalized mean entropy	S2146
OMA	1	1.010	-	-		QHG55102
OrthoDB	1	1.010	-	-		D66018at33208
OrthoFinder	1	1.000	-	-		FOG0005435
OrthoInspector	1	1.000	-	-		oto93311
orthoMCL	1	0.900	-	-		OOG6_102954
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3418
SonicParanoid	1	1.000	-	-		X3849
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750