Protein Alignment CG6959 and SLIT2

DIOPT Version :10

• Sequence 1: NP_650122.1
• Gene: CG6959 / 41434
• FlyBaseID: FBgn0037956
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: XP_005248268.1
• Gene: SLIT2 / 9353
• HGNCID: 11086
• Length: 1533
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 85/437 - (19%)
• Similarity: 140/437 - (32%)
• Gaps: 190/437 - (43%)

  Fly    32 PAACSCGQEMYESEMQYVVNCTNAGLVNTSVLEFMPEQVEVLIFTGNRITELPWNVFGSINNYKQ 96
            ||||:|...        :|:|...||  |.:...:||.:..:....|.|..:|   .|:.:.||:
Human   278 PAACTCSNN--------IVDCRGKGL--TEIPTNLPETITEIRLEQNTIKVIP---PGAFSPYKK 329

  Fly    97 LRIVDMSSNHIREIR----------------GKSYHHVPR--------VERLILNHNNLS----- 132
            ||.:|:|:|.|.|:.                |.....:|:        ::.|:||.|.::
Human   330 LRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 394

  Fly   133 ----------ISRYEDEVNHHHPRVFSNFINLQSLHL-------------------TDAFEDN-- 166
                      :|.|::::.......||....:|::||                   |:..|.:
Human   395 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA 459

  Fly   167 --SSPQL--------------------------SEDLH-----DIFV------------------ 180
              :||:.                          :||..     |.|.
Human   460 RCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCS 524

  Fly   181 NSQLVKL--------QKLHLEQNEITHFKDRNVFCDLPSLRDLHLGDNDLRDLN---FE------ 228
            |.:|.|:        .:|.|..||.|..:...:|..||.||.::..:|.:.|:.   ||
Human   525 NQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVN 589

  Fly   229 --------------------------------VRCLNN--------LRFLDLERNKFSFVKPTDL 253
                                            :.|:.|        :|.|.|..|:.:.|.|...
Human   590 EILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAF 654

  Fly   254 RVLNELEERPNRTANLIVDFNLNPFGCDCRTAPFRAWITTTRVTVRN 300
            ..|:.|.     |.||:.    |||.|:|..|....|:...|:...|
Human   655 DTLHSLS-----TLNLLA----NPFNCNCYLAWLGEWLRKKRIVTGN 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_650122.1	LRR	<69..>278	CDD:443914	65/376 (17%)
		leucine-rich repeat	70..96	CDD:275380	5/25 (20%)
		leucine-rich repeat	97..120	CDD:275380	8/38 (21%)
		leucine-rich repeat	121..153	CDD:275380	8/46 (17%)
		leucine-rich repeat	154..186	CDD:275380	13/103 (13%)
		leucine-rich repeat	187..211	CDD:275380	7/31 (23%)
		leucine-rich repeat	212..234	CDD:275380	7/62 (11%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	276..328	CDD:214507	9/25 (36%)
SLIT2	XP_005248268.1	LRRNT	27..58	CDD:214470
		leucine-rich repeat	38..56	CDD:275380
		LRR	<56..>211	CDD:443914
		leucine-rich repeat	57..80	CDD:275380
		leucine-rich repeat	81..104	CDD:275380
		leucine-rich repeat	105..128	CDD:275380
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380
		leucine-rich repeat	177..200	CDD:275380
		PCC	182..>260	CDD:188093
		leucine-rich repeat	201..329	CDD:275380	17/63 (27%)
		LRRNT	276..308	CDD:214470	12/39 (31%)
		LRR	<323..671	CDD:443914	62/356 (17%)
		leucine-rich repeat	330..353	CDD:275380	7/22 (32%)
		leucine-rich repeat	354..374	CDD:275380	2/19 (11%)
		leucine-rich repeat	378..401	CDD:275380	4/22 (18%)
		leucine-rich repeat	402..423	CDD:275380	4/20 (20%)
		leucine-rich repeat	426..527	CDD:275380	12/100 (12%)
		LRR	519..>865	CDD:443914	39/183 (21%)
		leucine-rich repeat	541..563	CDD:275380	7/21 (33%)
		leucine-rich repeat	564..587	CDD:275380	6/22 (27%)
		leucine-rich repeat	588..611	CDD:275380	0/22 (0%)
		leucine-rich repeat	612..635	CDD:275380	2/22 (9%)
		leucine-rich repeat	636..659	CDD:275380	7/22 (32%)
		leucine-rich repeat	660..751	CDD:275380	13/42 (31%)
		leucine-rich repeat	752..782	CDD:275380
		leucine-rich repeat	783..806	CDD:275380
		leucine-rich repeat	807..830	CDD:275380
		leucine-rich repeat	831..852	CDD:275380
		PCC	836..>1017	CDD:188093
		leucine-rich repeat	855..867	CDD:275378
		EGF_CA	1002..1038	CDD:238011
		EGF_CA	1042..1077	CDD:238011
		EGF_CA	1080..1116	CDD:238011
		EGF_CA	<1134..1161	CDD:238011
		LamG	1187..1320	CDD:214598