Protein Alignment CG6959 and TPBG

DIOPT Version :10

• Sequence 1: NP_650122.1
• Gene: CG6959 / 41434
• FlyBaseID: FBgn0037956
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_006661.1
• Gene: TPBG / 7162
• HGNCID: 12004
• Length: 420
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 106/375 - (28%)
• Similarity: 160/375 - (42%)
• Gaps: 65/375 - (17%)

  Fly    32 PAACSCGQEMYESEMQYVVNCTNAGLVNTSVLEFMPEQVEVLIFTGNRITELPWNVFGSINNYKQ 96
            ||.|.|      ||....|.|.|..|  |.|...:|..|..|..|||::..||...|.......:
Human    63 PALCEC------SEAARTVKCVNRNL--TEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAE 119

  Fly    97 LRIVDMSSNHIREIRGKSYHHVPRVERLILNHNNLS-ISRYEDEVNHHHPRVFSNFINLQSLHLT 160
            |..:::|.:.:.|:|..::.|:|.:.:|.|:||.|: :|.:....::......|..:.|...|:.
Human   120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIV 184

  Fly   161 DAFEDNSSPQLSEDL--HDIFVNSQLVKLQKLHLEQNEITHFKDRNVFCDLPSLRDLHLGDNDLR 223
            .. ||....:..|.:  ..:.....|..|::|.|..|...:. .|:|...|||||.|.|.:|.|.
Human   185 PP-EDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYL-PRDVLAQLPSLRHLDLSNNSLV 247

  Fly   224 DLNF-EVRCLNNLRFLDLERNKFSFVKPTDLRVLN-----ELEERPNRTANLIVDFNLNPFGCDC 282
            .|.: ..|.|.:|..|.||.|.        |:||:     ||:..|    ::.|..:.||:.|||
Human   248 SLTYVSFRNLTHLESLHLEDNA--------LKVLHNGTLAELQGLP----HIRVFLDNNPWVCDC 300

  Fly   283 RTAPFRAWITTTRVTVRNKDSLMCFHSTGHVDAEPAHLLQMDMGQCADAIAAAATILNTAEDEPH 347
            ..|....|:..|.| |:.||.|.|        |.|..:....:.:           ||:|:.:
Human   301 HMADMVTWLKETEV-VQGKDRLTC--------AYPEKMRNRVLLE-----------LNSADLD-- 343

  Fly   348 YGDPEASHLQPQAHISGHTATLIFLLIVLTMILLGLLVALV-YVSRDKLK 396
             .||   .|.|....|     .:||.|||.  |:|.:..|| |::|..:|
Human   344 -CDP---ILPPSLQTS-----YVFLGIVLA--LIGAIFLLVLYLNRKGIK 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_650122.1	LRR	<69..>278	CDD:443914	58/217 (27%)
		leucine-rich repeat	70..96	CDD:275380	8/25 (32%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..153	CDD:275380	7/32 (22%)
		leucine-rich repeat	154..186	CDD:275380	6/33 (18%)
		leucine-rich repeat	187..211	CDD:275380	7/23 (30%)
		leucine-rich repeat	212..234	CDD:275380	9/22 (41%)
		leucine-rich repeat	235..258	CDD:275380	8/27 (30%)
		LRRCT	276..328	CDD:214507	16/51 (31%)
TPBG	NP_006661.1	LRRNT	61..95	CDD:214470	14/39 (36%)
		leucine-rich repeat	73..95	CDD:275380	8/23 (35%)
		LRR	<79..>285	CDD:443914	60/217 (28%)
		LRR 1. /evidence=ECO:0000269|PubMed:24582434	92..113		8/20 (40%)
		leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		LRR 2. /evidence=ECO:0000269|PubMed:24582434	116..139		4/22 (18%)
		leucine-rich repeat	120..143	CDD:275380	5/22 (23%)
		LRR 3. /evidence=ECO:0000269|PubMed:24582434	141..163		7/21 (33%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		LRR 4. /evidence=ECO:0000269|PubMed:24582434	172..204		6/32 (19%)
		leucine-rich repeat	175..211	CDD:275380	6/36 (17%)
		LRR 5. /evidence=ECO:0000269|PubMed:24582434	209..232		7/23 (30%)
		leucine-rich repeat	212..235	CDD:275380	7/23 (30%)
		LRR 6. /evidence=ECO:0000269|PubMed:24582434	233..255		10/21 (48%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		LRR 7. /evidence=ECO:0000269|PubMed:24582434	256..275		9/26 (35%)
		leucine-rich repeat	260..283	CDD:275380	10/30 (33%)
		LRRCT	294..345	CDD:214507	19/73 (26%)