DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6959 and TLR5

DIOPT Version :9

Sequence 1:	NP_001138037.1	Gene:	CG6959 / 41434	FlyBaseID:	FBgn0037956	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens

Alignment Length:	316	Identity:	74/316 - (23%)
Similarity:	138/316 - (43%)	Gaps:	92/316 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VNTSVLEFMPEQVEVLIFTGNRITELPWNVFGSINNYKQLRIVDMSSNHIREIRGKSYHHVPRVE 122
            :|:.|.|.: :.::||....|:|.::....|..::|   |:::::|.|.:.|:...:::.:|:|.
Human   303 LNSRVFETL-KDLKVLNLAYNKINKIADEAFYGLDN---LQVLNLSYNLLGELYSSNFYGLPKVA 363

  Fly   123 RLILNHNNLSISRYEDEVNHHHPRVFSNFINLQSLHLTDAFEDNSSPQLS--EDLHDIFVN-SQL 184
            .:.|..|:::|  .:|:       .|.....||:|.|    .||:...:.  ..:.|||:: ::|
Human   364 YIDLQKNHIAI--IQDQ-------TFKFLEKLQTLDL----RDNALTTIHFIPSIPDIFLSGNKL 415

  Fly   185 VKLQK-------LHLEQN-----EITHF-------------KDRNVFC-------DLPSLRDLHL 217
            |.|.|       :||.:|     :|.:|             ::|...|       :.|||..|.|
Human   416 VTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480

  Fly   218 GDNDLR---------DL-----NFEVRCLNN----------------LRFLDLERNKFSFVK--- 249
            |:|.|:         |:     :.:|..||:                ||.|.|..|:.:.:.
Human   481 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHND 545

  Fly   250 -PTDLRVL----NE-LEERPNRTANL-IVDFNLNPFGCDCRTAPFRAWITTTRVTV 298
             |.:|.:|    |: |...|:...:| ::|...|.|.|:|..:.|..|:..|.||:
Human   546 LPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTI 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_001138037.1	leucine-rich repeat	70..96	CDD:275380	6/25 (24%)
		LRR_8	95..161	CDD:290566	15/65 (23%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		LRR_RI	<116..>224	CDD:238064	35/151 (23%)
		leucine-rich repeat	121..153	CDD:275380	6/31 (19%)
		leucine-rich repeat	154..186	CDD:275380	10/34 (29%)
		LRR_8	186..245	CDD:290566	26/120 (22%)
		leucine-rich repeat	187..211	CDD:275380	9/55 (16%)
		leucine-rich repeat	212..234	CDD:275380	9/35 (26%)
		leucine-rich repeat	235..258	CDD:275380	8/30 (27%)
		TPKR_C2	276..328	CDD:301599	9/23 (39%)
TLR5	NP_003259.2	LRR 1. /evidence=ECO:0000269\|PubMed:22173220	45..68
		leucine-rich repeat	48..83	CDD:275378
		LRR 2. /evidence=ECO:0000269\|PubMed:22173220	71..93
		PLN00113	90..>581	CDD:331614	66/294 (22%)
		LRR 3. /evidence=ECO:0000269\|PubMed:22173220	95..117
		leucine-rich repeat	97..120	CDD:275380
		LRR 4. /evidence=ECO:0000269\|PubMed:22173220	120..143
		leucine-rich repeat	121..146	CDD:275380
		LRR 5. /evidence=ECO:0000269\|PubMed:22173220	146..166
		leucine-rich repeat	147..171	CDD:275380
		LRR 6. /evidence=ECO:0000269\|PubMed:22173220	171..192
		leucine-rich repeat	172..205	CDD:275380
		LRR 7. /evidence=ECO:0000269\|PubMed:22173220	197..211
		LRR 8. /evidence=ECO:0000269\|PubMed:22173220	214..229
		LRR 9. /evidence=ECO:0000269\|PubMed:22173220	234..235
		LRR 11. /evidence=ECO:0000269\|PubMed:22173220	260..284
		LRR_8	288..348	CDD:316378	12/48 (25%)
		LRR 12. /evidence=ECO:0000269\|PubMed:22173220	289..301
		leucine-rich repeat	290..313	CDD:275380	3/10 (30%)
		LRR 13. /evidence=ECO:0000269\|PubMed:22173220	313..334		5/20 (25%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		LRR 14. /evidence=ECO:0000269\|PubMed:22173220	337..355		5/20 (25%)
		leucine-rich repeat	338..361	CDD:275380	4/22 (18%)
		leucine-rich repeat	362..385	CDD:275380	6/31 (19%)
		LRR 16. /evidence=ECO:0000269\|PubMed:22173220	385..401		6/19 (32%)
		leucine-rich repeat	386..414	CDD:275380	9/31 (29%)
		LRR 17. /evidence=ECO:0000269\|PubMed:22173220	412..431		5/18 (28%)
		leucine-rich repeat	415..449	CDD:275380	9/33 (27%)
		LRR 18. /evidence=ECO:0000269\|PubMed:22173220	449..470		2/20 (10%)
		leucine-rich repeat	450..474	CDD:275380	2/23 (9%)
		LRR_8	473..538	CDD:316378	17/64 (27%)
		LRR 19. /evidence=ECO:0000269\|PubMed:22173220	474..495		7/20 (35%)
		leucine-rich repeat	475..503	CDD:275380	7/27 (26%)
		LRR 20. /evidence=ECO:0000269\|PubMed:22173220	503..524		3/20 (15%)
		leucine-rich repeat	504..527	CDD:275380	3/22 (14%)
		LRR 21. /evidence=ECO:0000269\|PubMed:22173220	527..546		5/18 (28%)
		leucine-rich repeat	528..549	CDD:275380	6/20 (30%)
		LRR 22. /evidence=ECO:0000269\|PubMed:22173220	549..567		5/17 (29%)
		leucine-rich repeat	550..571	CDD:275380	5/20 (25%)
		PCC	554..>634	CDD:188093	14/48 (29%)
		TIR	693..837	CDD:307630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910