Protein Alignment CG6959 and SLIT3

DIOPT Version :10

• Sequence 1: NP_650122.1
• Gene: CG6959 / 41434
• FlyBaseID: FBgn0037956
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_001258875.2
• Gene: SLIT3 / 6586
• HGNCID: 11087
• Length: 1530
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 81/438 - (18%)
• Similarity: 143/438 - (32%)
• Gaps: 186/438 - (42%)

  Fly    23 NSSSCGPNFPAACSCGQEMYESEMQYVVNCTNAGLVNTSVLEFMPEQVEVLIFTGNRITELPWNV 87
            ||.||    |:.|:|...        :|:|...||:  .:...:||.:..:....|.|..:|
Human   276 NSISC----PSPCTCSNN--------IVDCRGKGLM--EIPANLPEGIVEIRLEQNSIKAIP--- 323

  Fly    88 FGSINNYKQLRIVDMSSNHIREIRGKSYHHVPRVERLILNHNNLS-------------------- 132
            .|:...||:|:.:|:|.|.|.:|...::..:..:..|:|..|.::
Human   324 AGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNA 388

  Fly   133 -------------------ISRYEDEVNHHHPRVFSNFINLQSLH--------------LTDAFE 164
                               :|.|::::......:|:...::|:||              |.|..:
Human   389 NKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQ 453

  Fly   165 DN---------SSPQL------------------SEDLHDIF----------------------- 179
            ||         |||:.                  |||....|
Human   454 DNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDC 518

  Fly   180 VNSQLVKLQK--------LHLEQNEITHFKDRNVFCDLPSLRDLHLGDNDLRDLN---FE----- 228
            .|.:||::..        |.|..||::..:...:|..||:||.::|.:|.::::.   |:
Human   519 SNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASV 583

  Fly   229 ---------------------------------VRCLNN--------LRFLDLERNKFSFVKPTD 252
                                             :.|::|        :|.|.|..|:.:.:.|..
Human   584 QELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGA 648

  Fly   253 LRVLNELEERPNRTANLIVDFNLNPFGCDCRTAPFRAWITTTRVTVRN 300
            ...|..|.     |.||:    .|||.|:|..|....|:...|:...|
Human   649 FTTLVSLS-----TINLL----SNPFNCNCHLAWLGKWLRKRRIVSGN 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_650122.1	LRR	<69..>278	CDD:443914	60/368 (16%)
		leucine-rich repeat	70..96	CDD:275380	5/25 (20%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..153	CDD:275380	6/70 (9%)
		leucine-rich repeat	154..186	CDD:275380	16/95 (17%)
		leucine-rich repeat	187..211	CDD:275380	6/31 (19%)
		leucine-rich repeat	212..234	CDD:275380	6/62 (10%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	276..328	CDD:214507	9/25 (36%)
SLIT3	NP_001258875.2	LRRNT	33..64	CDD:214470
		LRR	<62..>217	CDD:443914
		LRR 1	62..83
		leucine-rich repeat	64..86	CDD:275380
		LRR 2	86..107
		leucine-rich repeat	87..110	CDD:275380
		LRR 3	110..131
		leucine-rich repeat	111..134	CDD:275380
		LRR 4	134..155
		leucine-rich repeat	135..158	CDD:275380
		LRR 5	158..179
		leucine-rich repeat	159..182	CDD:275380
		LRR 6	182..203
		leucine-rich repeat	183..206	CDD:275380
		PCC	188..>250	CDD:188093
		leucine-rich repeat	207..308	CDD:275380	12/45 (27%)
		LRRNT	280..311	CDD:214470	10/44 (23%)
		LRR 7	308..329		4/23 (17%)
		leucine-rich repeat	309..332	CDD:275380	5/25 (20%)
		LRR	<326..666	CDD:443914	57/348 (16%)
		LRR 8	332..353		6/20 (30%)
		leucine-rich repeat	333..356	CDD:275380	6/22 (27%)
		LRR 9	356..377		3/20 (15%)
		leucine-rich repeat	357..377	CDD:275380	3/19 (16%)
		LRR 10	380..401		0/20 (0%)
		leucine-rich repeat	381..404	CDD:275380	0/22 (0%)
		LRR 11	404..425		3/20 (15%)
		leucine-rich repeat	405..428	CDD:275380	3/22 (14%)
		LRR 12	533..554		4/20 (20%)
		leucine-rich repeat	534..558	CDD:275380	6/23 (26%)
		LRR 13	558..579		5/20 (25%)
		leucine-rich repeat	559..582	CDD:275380	5/22 (23%)
		LRR 14	582..603		0/20 (0%)
		leucine-rich repeat	583..606	CDD:275380	0/22 (0%)
		LRR	588..>900	CDD:443914	21/109 (19%)
		LRR 15	606..627		2/20 (10%)
		leucine-rich repeat	607..630	CDD:275380	2/22 (9%)
		LRR 16	630..651		5/20 (25%)
		leucine-rich repeat	631..654	CDD:275380	6/22 (27%)
		leucine-rich repeat	655..745	CDD:275380	13/42 (31%)
		leucine-rich repeat	746..776	CDD:275380
		LRR 17	753..775
		LRR 18	776..797
		leucine-rich repeat	777..800	CDD:275380
		LRR 19	800..821
		leucine-rich repeat	801..824	CDD:275380
		LRR 20	824..845
		leucine-rich repeat	825..846	CDD:275380
		EGF_CA	963..1001	CDD:238011
		EGF_CA	1005..1038	CDD:238011
		EGF_CA	1042..1079	CDD:238011
		EGF_CA	1081..1117	CDD:238011
		EGF	1130..1160	CDD:394967
		Laminin_G_2	1195..1321	CDD:460494
		EGF	1379..1407	CDD:394967
		GHB_like	<1473..1528	CDD:473907