DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6959 and tpbga

DIOPT Version :9

Sequence 1:	NP_001138037.1	Gene:	CG6959 / 41434	FlyBaseID:	FBgn0037956	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_919373.2	Gene:	tpbga / 373095	ZFINID:	ZDB-GENE-030827-4	Length:	372	Species:	Danio rerio

Alignment Length:	404	Identity:	103/404 - (25%)
Similarity:	159/404 - (39%)	Gaps:	77/404 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AIILAIGAGGVLGENSSSCGPNFPAACSCGQEMYESEMQYVVNCTNAGLVNTSVLEFMPEQVEVL 73
            |::|.:.....:...:..|    |..|.|      ||....|.|.:..|  ..:...:|.....|
Zfish     8 AVVLGLLCAAAVSAGALVC----PTGCEC------SEAALTVKCVSKDL--RDIPSGIPGYTRNL 60

  Fly    74 IFTGNRITELPWNVFGSINNYKQLRIVDMSSNHIREIRGKSYHHVPRVERLILNHNNLSISRYED 138
            ..|||.|:::....|..:.|...|   .:|:|.|.|::..::..:..:..|.|::|.|::.
Zfish    61 FITGNHISQIGPESFQGLENVTNL---SLSNNRISEVKSHTFSSLRSLRSLDLSNNQLAVI---- 118

  Fly   139 EVNHHHPRVFS-NFINLQSLHLTDAFEDNSSPQLSEDLHDIFVNSQLVKLQKLHLEQNEITHFKD 202
                 ||..|: ....|:.|:|:.|..::||..   ||......|.|..|..|.|..|.:. |..
Zfish   119 -----HPEAFTVQSRMLRELNLSRALYNHSSVM---DLATSLRWSSLSDLLVLDLSSNGLV-FLP 174

  Fly   203 RNVFCDLPSLRDLHLGDNDLRDL-NFEVRCLNNLRFLDLERNKFSFVKPTDLRVLNELEERPNRT 266
            ..:||.|..||.|.||:|.:..: |.....|::|:.|||..|....::...|:.|.:|.......
Zfish   175 SGIFCHLVGLRRLQLGNNSIVSIHNGTFTGLDHLQELDLTHNALRTLREEALKELEQLHSARLHL 239

  Fly   267 ANLIVDFNLNPFGCDCRTAPFRAWITTTRVTVRNKDSLMCFHSTGHVDAEPAHLLQMDMGQCADA 331
            |:       |||.|.|...||.||:..:|..|              ||.|..        .||..
Zfish   240 AD-------NPFTCTCDIEPFAAWLNGSRGQV--------------VDIEGL--------TCAFP 275

  Fly   332 IAAAATILNTAEDEPHYGDPEASHLQPQAHISGHTATL------IFLLIVLTMILLGLLVALVYV 390
            :|...|.|.|..|           |:...|.:|.:..|      :||.:||..:.|..|..| |:
Zfish   276 VALHNTSLLTVGD-----------LELGCHKAGDSDNLALQTSYVFLGLVLGFVGLMFLFVL-YL 328

  Fly   391 SRDKLKYMITPVFD 404
            :|..:|..|..:.|
Zfish   329 NRKDIKKRIYDMRD 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_001138037.1	leucine-rich repeat	70..96	CDD:275380	7/25 (28%)
		LRR_8	95..161	CDD:290566	15/66 (23%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		LRR_RI	<116..>224	CDD:238064	31/108 (29%)
		leucine-rich repeat	121..153	CDD:275380	7/32 (22%)
		leucine-rich repeat	154..186	CDD:275380	10/31 (32%)
		LRR_8	186..245	CDD:290566	21/59 (36%)
		leucine-rich repeat	187..211	CDD:275380	8/23 (35%)
		leucine-rich repeat	212..234	CDD:275380	8/22 (36%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		TPKR_C2	276..328	CDD:301599	14/51 (27%)
tpbga	NP_919373.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I5166
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D341562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24364
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.070