Protein Alignment CG6959 and Lrrn2

DIOPT Version :10

• Sequence 1: NP_650122.1
• Gene: CG6959 / 41434
• FlyBaseID: FBgn0037956
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_034862.1
• Gene: Lrrn2 / 16980
• MGIID: 106037
• Length: 730
• Species: Mus musculus
• Alignment Length: 493
• Identity: 109/493 - (22%)
• Similarity: 170/493 - (34%)
• Gaps: 171/493 - (34%)

  Fly     7 IAAIILAIGAGGVLGENSSSCGP------NFPAACSCG-QEMYESEMQY----VVNCTNAGLVNT 60
            :||::|:..||      :::..|      ..|..|:|. :..|.....|    .|:|.:  |..|
Mouse     5 VAALLLSWVAG------TTAAAPVVPWRVPCPPQCACQIRPWYTPRSSYREATTVDCND--LFLT 61

  Fly    61 SVLEFMPEQVEVLIFTGNRITELPWNVFGSINNYKQLRIVDMSSNHIREIRGKSYHHVPRVERLI 125
            :|...:|...:.|:...|.|:.:.......:.|..:|   |:|.|...:.|...:..:|::..|.
Mouse    62 AVPPRLPAGTQTLLLQSNSISRIDQTELAYLANLTEL---DLSQNSFSDARDCDFQALPQLLSLH 123

  Fly   126 LNHNNLSISRYEDE------------VNHHH-----PRVFSNFINLQSLHL-------------- 159
            |..|.|  :|.||.            :||:.     ||.|:...||..|||
Mouse   124 LEENRL--NRLEDHSFAGLTSLQELYLNHNQLCRISPRAFAGLGNLLRLHLNSNLLRTIDSRWFE 186

  Fly   160 --------------TDAFED-NSSP---------------QLS----EDLHDI----FVNSQLVK 186
                          .||..| |..|               ::|    |.|..:    |.::||.:
Mouse   187 MLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQ 251

  Fly   187 LQKLHLEQNEITHFKDRNV----------FCDLPSLRDLHLGDNDLRDL----NFEVRCLNNLRF 237
            :.|..|||.....|.|.|.          |.::..|::  ||.|::.:|    .|.:..|..|..
Mouse   252 VPKRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKE--LGLNNMEELVSIDKFALVNLPELTK 314

  Fly   238 LDLERN-KFSFVKP--------TDLRVLNE----------LEERPNRTANLIVDFNLNPFGCDCR 283
            ||:..| :.||:.|        .:..:||.          :|..||...   |..:.||..|||
Mouse   315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE---VGLHGNPIRCDC- 375

  Fly   284 TAPFRAWITTTRVTVR--NKDSLMCFHSTGHVDAEPAHLLQMDMGQ---------CADAI----- 332
               ...|...|...||  ...|.:|        |||..|.:..:.:         |...|
Mouse   376 ---VIRWANATGTHVRFIEPQSTLC--------AEPPDLQRRPVREVPFREMTDHCLPLISPRSF 429

  Fly   333 -------AAAATILN---TAEDEP--HYGDPEASHLQP 358
                   :..:|:|:   .||.||  ::..|....|.|
Mouse   430 PSSLQIASGESTVLHCRALAEPEPEIYWVTPAGVRLTP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6959	NP_650122.1	LRR	<69..>278	CDD:443914	67/310 (22%)
		leucine-rich repeat	70..96	CDD:275380	4/25 (16%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..153	CDD:275380	12/48 (25%)
		leucine-rich repeat	154..186	CDD:275380	15/83 (18%)
		leucine-rich repeat	187..211	CDD:275380	8/33 (24%)
		leucine-rich repeat	212..234	CDD:275380	7/25 (28%)
		leucine-rich repeat	235..258	CDD:275380	8/31 (26%)
		LRRCT	276..328	CDD:214507	15/62 (24%)
Lrrn2	NP_034862.1	LRRNT	28..72	CDD:214470	11/45 (24%)
		leucine-rich repeat	51..69	CDD:275380	5/19 (26%)
		leucine-rich repeat	71..94	CDD:275380	3/22 (14%)
		LRR	<85..>324	CDD:443914	54/245 (22%)
		leucine-rich repeat	95..118	CDD:275380	5/25 (20%)
		leucine-rich repeat	119..142	CDD:275380	7/24 (29%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		leucine-rich repeat	167..190	CDD:275380	4/22 (18%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..238	CDD:275380	3/22 (14%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
		leucine-rich repeat	263..286	CDD:275380	4/22 (18%)
		leucine-rich repeat	287..311	CDD:275380	7/25 (28%)
		LRR_8	310..371	CDD:404697	14/63 (22%)
		leucine-rich repeat	312..334	CDD:275380	7/21 (33%)
		leucine-rich repeat	337..360	CDD:275378	3/22 (14%)
		PCC	342..>420	CDD:188093	21/92 (23%)
		leucine-rich repeat	361..373	CDD:275378	3/14 (21%)
		Ig	430..514	CDD:472250	9/38 (24%)
		Ig strand B	441..445	CDD:409421	2/3 (67%)
		Ig strand C	454..458	CDD:409421	0/3 (0%)
		Ig strand E	480..484	CDD:409421
		Ig strand F	494..499	CDD:409421
		Ig strand G	507..510	CDD:409421