DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lck and Src42A

DIOPT Version :9

Sequence 1:	NP_001001596.1	Gene:	lck / 414333	ZFINID:	ZDB-GENE-040617-1	Length:	503	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	220/394 - (55%)
Similarity:	286/394 - (72%)	Gaps:	13/394 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish   115 METEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHYRIRNM 179
            :..:.|:::.:.|.:|.::||.|.|..|:||||:||::...:|:||||     ||.:||||||.:
  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQL 1264

Zfish   180 DAGGFYITNKISFNSLSELVKHYSREADGLCTRLVKPC-QTRAPQKPW----WQDEWEVPRESLK 239
            |.|||:|..:.:|.:|.|||:|||:::||||..|.||| |...|....    .:|:||:.|.|||
  Fly  1265 DEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLK 1329

Zfish   240 LERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQHPRLVRLFAVVT-QE 303
            ..|:||.||||:||.||:||...||||:||.|||....|||||.:||.|:|.:|::|:||.| :|
  Fly  1330 FVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE 1394

Zfish   304 PIYIITEYMENGSLVDFLK--TPEGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRDLRAANILVS 366
            |||||||.|::|||:::|:  ..:|..:.:.||||||||:|.||||:|.:|||||||.|.|:||.
  Fly  1395 PIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVG 1459

Zfish   367 HELTCKIADFGLARLIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGR 431
            .....||||||||||||.:||.||.||:||||||||||.||..|||||||||||:||||:|||||
  Fly  1460 DGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR 1524

Zfish   432 IPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVLEDFFTATEG 496
            ||||||||.||:..:|.|||||.|.||...||.:|..||.::|..|||||.|:..||||:|:.:.
  Fly  1525 IPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQS 1589

Zfish   497 QYQE 500
            .|:|
  Fly  1590 DYKE 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938
		SH2_Src_Lck	116..216	CDD:198225	45/99 (45%)
		PTKc_Lck_Blk	230..493	CDD:270652	166/265 (63%)
		Pkinase_Tyr	238..487	CDD:285015	158/251 (63%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	45/95 (47%)
		PTKc_Frk_like	1319..1587	CDD:270653	168/267 (63%)
		Pkinase_Tyr	1328..1580	CDD:285015	158/251 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920