DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kyat and KYAT3

DIOPT Version :9

Sequence 1:	NP_650121.1	Gene:	Kyat / 41433	FlyBaseID:	FBgn0037955	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001008661.1	Gene:	KYAT3 / 56267	HGNCID:	33238	Length:	454	Species:	Homo sapiens

Alignment Length:	454	Identity:	238/454 - (52%)
Similarity:	312/454 - (68%)	Gaps:	24/454 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AKRSL-----REQFQLQALRHQQ-----TAIKME-KFDLPKRLQGSTPSVWNEYIALAMQYKPLN 65
            |:|||     |.:| |:.:...:     |:.||. ||...||::|...:||.|:..||.....:|
Human     4 AQRSLCSLSGRAKF-LKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVN 67

  Fly    66 LGQGFPDDAAPEYVTHSLADIAKEQNPLLHQYTRGYGHVRLVNALSKLYSGLVGKELNPLSDILI 130
            |||||||.:.|.||...|:.||...:  |:|||||:||..||.|||.||..|..|:::...:||:
Human    68 LGQGFPDISPPTYVKEELSKIAAIDS--LNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILV 130

  Fly   131 TSGAYEALYSTIMGHVDVGDEVIIIEPFFDCYEPMVKMAGGVPRFVPLKLRKTEGP-ISSADWVL 194
            |.|||.:|::||...:|.|||||:|.||:|||||||:|||..|.|:||:.:...|. .||:||.|
Human   131 TVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTL 195

  Fly   195 DDAEFESLFNSKTKMIILNTPHNPIGKVFNRKELERIAELCRKWNVLCVSDEVYEWLVFDGAEHI 259
            |..|.||.||||||.|||||||||:|||:||:||:.||:||.|::.||:|||||||||:.|.:|:
Human   196 DPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHL 260

  Fly   260 RICTLPGMWDRTITLGSAGKTFSVTGWKIGWAYGPAELIRNLQMVHQNSVYTCPTPLQEGVARSF 324
            :|.|.||||:||||:|||||||||||||:||:.||..||::||.|.||::|||.|||||.:|::|
Human   261 KIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAF 325

  Fly   325 EVELARLGQPESYFLSLPRELKQKRDFMAKFLSESGMRPTIPEGGYFMLADWSPLAGKIDLS--- 386
            .:::.|:..||.||.|||:||:.|||.|.:.|...|::|.:|:||||::||.|.|  ..|||
Human   326 WIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLL--DPDLSDMK 388

  Fly   387 -SEPDKHRDYKFTKWMTKNMGLQGIPPSAFYSEPNKHLGEDFVRYCFIKKQENLDKAAELLSKW 449
             :||   .||||.|||||:..|..||.|||.:...|...|.|||:|||||...||.|.|::..|
Human   389 NNEP---YDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAW 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kyat	NP_650121.1	PRK08912	56..449	CDD:181580	219/397 (55%)
Kyat	NP_650121.1	AAT_like	64..448	CDD:99734	217/388 (56%)
KYAT3	NP_001008661.1	PRK07777	44..449	CDD:236095	224/411 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160018
Domainoid	1	1.000	435	1.000	Domainoid score	I579
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2994
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1577
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53781
OrthoDB	1	1.010	-	-		D396367at33208
OrthoFinder	1	1.000	-	-		FOG0001158
OrthoInspector	1	1.000	-	-		otm41641
orthoMCL	1	0.900	-	-		OOG6_100255
Panther	1	1.100	-	-	O	PTHR43807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1782
SonicParanoid	1	1.000	-	-		X786
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840