DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kyat and SPAC6B12.04c

DIOPT Version :9

Sequence 1:	NP_650121.1	Gene:	Kyat / 41433	FlyBaseID:	FBgn0037955	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_593759.1	Gene:	SPAC6B12.04c / 2543228	PomBaseID:	SPAC6B12.04c	Length:	421	Species:	Schizosaccharomyces pombe

Alignment Length:	428	Identity:	152/428 - (35%)
Similarity:	240/428 - (56%)	Gaps:	39/428 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RLQGSTPSVW---NEYIALAMQYKPLNLGQGFPDDAAPEYVTHSLADIAKE--QNPLLHQYTRGY 101
            ::..|.|.||   |:..| ..:..|::|.|||.:...|::|    .|.||:  .....:||:...
pombe    11 KVAASRPDVWTLVNQATA-ECKVPPVSLSQGFFNYNPPKFV----LDAAKKSIDEVACNQYSHTR 70

  Fly   102 GHVRLVNALSKLYSGLVGKELNPLSDILITSGAYEALYSTIMGHVDVGDEVIIIEPFFDCYEPMV 166
            |...|..|||:.||....:.|||.::|::|:||.|..:|.....::.|||||::|||||.|...:
pombe    71 GRPSLRKALSEAYSPYFKRTLNPDTEIVVTAGANEGFFSVFAAFLNPGDEVIVMEPFFDQYISNI 135

  Fly   167 KMAGGVPRFVPLKLRKTEG---PISSADWVLDDAEFESLFNSKTKMIILNTPHNPIGKVFNRKEL 228
            .|.||||.:||: :...||   |:|:..|.||..:..:....|||||::||||||:||:|:.:||
pombe   136 TMNGGVPVYVPI-IPPEEGSVKPVSAGAWKLDMNKLRNAITEKTKMIVINTPHNPLGKIFSEEEL 199

  Fly   229 ERIAELCRKWNVLCVSDEVYEWLVFDGAEHIRICTL-PGMWDRTITLGSAGKTFSVTGWKIGWAY 292
            ..||:|..|.|:|.||||||:.|.|  ...:|:.|| |.::...:|:||.||||..|||::||..
pombe   200 NEIADLVLKHNLLVVSDEVYDRLSF--VPFVRLATLRPELFKHVVTVGSGGKTFGCTGWRVGWLI 262

  Fly   293 GPAELIRNLQMVHQNSVYTCPTPLQEGVARSFEVELARLGQPE--SYFLSLPRELKQKRDFMAKF 355
            |...||:.....|....:...:|.||.:|.:|       |:.|  :|:.......|::.:.:||.
pombe   263 GDESLIKYSAAAHTRICFAVNSPCQEALAIAF-------GEAEKHNYYEEYKSSYKKRFEILAKA 320

  Fly   356 LSESGMRPTIPEGGYFMLADWSPLAGKI--------DLSSEPDKHRDYKFTKWMTKNMGLQGIPP 412
            ..:..:..|||:|.|:.:|::|.|  |:        ::::.|   ||:|...|:.|.:|:..|||
pombe   321 FDQLEIPYTIPDGSYYTMANFSKL--KLPKDYPFPEEIANRP---RDFKLCYWILKEIGVATIPP 380

  Fly   413 SAFYSEPNKHLGEDFVRYCFIKKQENLDKAAELLSKWK 450
            :.||::.:..:.|:::|:.|.|..|.|::||..|.|.|
pombe   381 TEFYTDEDAPVAENYLRFAFCKTFETLEEAARRLQKLK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kyat	NP_650121.1	PRK08912	56..449	CDD:181580	145/408 (36%)
Kyat	NP_650121.1	AAT_like	64..448	CDD:99734	143/399 (36%)
SPAC6B12.04c	NP_593759.1	AspB	7..421	CDD:223513	152/428 (36%)
SPAC6B12.04c	NP_593759.1	AAT_like	35..416	CDD:99734	143/399 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	242	1.000	Domainoid score	I446
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2994
Inparanoid	1	1.050	252	1.000	Inparanoid score	I777
OMA	1	1.010	-	-		QHG53781
OrthoFinder	1	1.000	-	-		FOG0001158
OrthoInspector	1	1.000	-	-		oto101554
orthoMCL	1	0.900	-	-		OOG6_100255
Panther	1	1.100	-	-	LDO	PTHR43807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1782
SonicParanoid	1	1.000	-	-		X786
TreeFam	1	0.960	-	-
	14	13.860