DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment glo and Hnrnph3

DIOPT Version :9

Sequence 1:	NP_650120.1	Gene:	glo / 41431	FlyBaseID:	FBgn0259139	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001073293.1	Gene:	Hnrnph3 / 432467	MGIID:	1926462	Length:	346	Species:	Mus musculus

Alignment Length:	461	Identity:	136/461 - (29%)
Similarity:	184/461 - (39%)	Gaps:	186/461 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PKEAKEAMRKISGHGTAFVVKLRGLPYAVTEQQIEEFFSGLDIKTDREGILFVMDRRGRATGEAF 193
            |.:|.:        ||   |:|||||:..::::|.:||.||:|..:  ||...||.:||:|||||
Mouse    10 PNDASD--------GT---VRLRGLPFGCSKEEIVQFFQGLEIVPN--GITLTMDYQGRSTGEAF 61

  Fly   194 VQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMKRATGAGGG--------VGGRPGPYDIRDR 250
            |||.|::..|.|||:::|:||||||||||||.:|:|       |        :|.||||||
Mouse    62 VQFASKEIAENALGKHKERIGHRYIEIFRSSRSEIK-------GFYDPPRRLLGQRPGPYD---- 115

  Fly   251 GANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGGNNGNFGNNSGPSNFG 315
                        |...|..|.:|.|..:|.      ..|..|
Mouse   116 ------------RPIGGRGGYYGAGRGSMY------DRMRRG----------------------- 139

  Fly   316 NFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNNFNSPGGVNNFGNNGG 380
              |.|.:||                         :||             |:..||.||:|
Mouse   140 --GDGYDGG-------------------------YGG-------------FDDYGGYNNYG---- 160

  Fly   381 SNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFGGNNNVGSNFGGGNNGG 445
                                                   :||.||.:   ....|...||...||
Mouse   161 ---------------------------------------YGNDGFDD---RMRDGRGMGGHGYGG 183

  Fly   446 GGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFENDVFKFFEPIRPANVR 510
            .|..::|.:         ||:|               :||||||:.:.|||:..||.|:.|..|.
Mouse   184 AGDASSGFH---------GGHF---------------VHMRGLPFRATENDIANFFSPLNPIRVH 224

  Fly   511 INYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRGLNGGEHGGGNGGGGMG 575
            |:....|..:|.||..|.|:||:..||.:.:..|..||||||.: .|.|  ||...||:|.||.|
Mouse   225 IDIGADGRATGEADVEFVTHEDAVAAMSKDKNNMQHRYIELFLN-STPG--GGSGMGGSGMGGYG 286

  Fly   576 NNGGGN 581
            .:|..|
Mouse   287 RDGMDN 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_SF	51..125	CDD:302621
		RRM2_hnRNPH_like	146..224	CDD:240948	42/77 (55%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:240950	32/73 (44%)
Hnrnph3	NP_001073293.1	RRM2_hnRNPH3	1..93	CDD:410131	47/95 (49%)
Hnrnph3	NP_001073293.1	RRM3_hnRNPH3	195..269	CDD:241179	33/89 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845695
Domainoid	1	1.000	78	1.000	Domainoid score	I8739
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3318
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	1	1.000	-	-		FOG0000855
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900