DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment glo and RBM12B

DIOPT Version :9

Sequence 1:	NP_650120.1	Gene:	glo / 41431	FlyBaseID:	FBgn0259139	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001364889.1	Gene:	RBM12B / 389677	HGNCID:	32310	Length:	1001	Species:	Homo sapiens

Alignment Length:	236	Identity:	59/236 - (25%)
Similarity:	94/236 - (39%)	Gaps:	73/236 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115
            :||.|||:.|...:|..|...:.:.:|  |:|::     |...|||::..|:.||...|...:..
Human     5 IRLLGLPFIAGPVDIRHFFTGLTIPDG--GVHII-----GGEIGEAFIIFATDEDARRAISRSGG 62

  Fly   116 SMGHRYIEVFTATPKEAKEAM---------RKISGHGTAFV---------VK------------- 149
            .:....:|:|.::..|.::.:         |...|.||:.|         ||
Human    63 FIKDSSVELFLSSKAEMQKTIEMKRTDRVGRGRPGSGTSGVDSLSNFIESVKEEASNSGYGSSIN 127

  Fly   150 -------------------------------LRGLPYAVTEQQIEEFFSGLDIKTDREGILFVMD 183
                                           ||||||.|.|..:..|||||.:    :|::|:..
Human   128 QDAGFHTNGTGHGNLRPRKTRPLKAENPYLFLRGLPYLVNEDDVRVFFSGLCV----DGVIFLKH 188

  Fly   184 RRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSS 224
            ..||..|:|.|:|.|..|....|..:|..:|.|:||:.:.|
Human   189 HDGRNNGDAIVKFASCVDASGGLKCHRSFMGSRFIEVMQGS 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_SF	51..125	CDD:302621	20/73 (27%)
		RRM2_hnRNPH_like	146..224	CDD:240948	32/130 (25%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:240950
RBM12B	NP_001364889.1	RRM1_RBM12B	2..80	CDD:410139	22/81 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..147		0/27 (0%)
		RRM2_RBM12B	153..238	CDD:410140	30/81 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..278
		RRM3_RBM12B	284..363	CDD:409935
		RRM4_RBM12B	400..475	CDD:410142
		PTZ00121	<449..680	CDD:173412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..882
		PHA03321	<689..915	CDD:223041
		RRM5_RBM12B	925..1001	CDD:410144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840