DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment glo and hnrnph1l

DIOPT Version :9

Sequence 1:	NP_650120.1	Gene:	glo / 41431	FlyBaseID:	FBgn0259139	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_997754.2	Gene:	hnrnph1l / 321556	ZFINID:	ZDB-GENE-030131-275	Length:	407	Species:	Danio rerio

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	226/550 - (41%)	Gaps:	217/550 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115
            ||:||||||.:.:|:..|.....:::..:.||...:| :|:.:|||:||:.|::|::.|.|.::.
Zfish     9 VRVRGLPWSCSAEEVSRFFSGCKISSNGSAIHFTYTR-EGRPSGEAFVELESEDDLKIAVKKDRE 72

  Fly   116 SMGHRYIEVFTATPKEAKEAMR-------KISGHGTAFVVKLRGLPYAVTEQQIEEFFSGLDIKT 173
            ||||||:|||.:...|....::       :..|.|   :|:|||||:..::::|.:|||||:|..
Zfish    73 SMGHRYVEVFKSNNVEMDWVLKHTGPNCPETEGDG---LVRLRGLPFGCSKEEIVQFFSGLEIVP 134

  Fly   174 DREGILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMK---RATGAG 235
            :  ||...:|.:||:||||||||.|||..|:||.:::|:|||||||||:||.||::   .....|
Zfish   135 N--GITLPVDFQGRSTGEAFVQFASQDIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYEPPRKG 197

  Fly   236 GGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGG 300
            .|: .||||||          ...||||                 |:|
Zfish   198 MGM-QRPGPYD----------RPSGGGR-----------------GYN----------------- 217

  Fly   301 NNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNN 365
                                                      |.:.||:|.....||.|
Zfish   218 ------------------------------------------GMSRGGSFDRMRRGGYG------ 234

  Fly   366 FNSPGGVNNFGNNGGSNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFGG 430
                |||::              |.:.:||||.|::|
Zfish   235 ----GGVSD--------------GRYGDGGNFQSTTG---------------------------- 253

  Fly   431 NNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFEN 495
                                                              :.:|||||||.:.|.
Zfish   254 --------------------------------------------------HCVHMRGLPYRATEP 268

  Fly   496 DVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRGL 560
            |::.||.|:.|..|.|.....|..:|.||..|.|:||:..||.:.:..|..||:|||.:....|.
Zfish   269 DIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGGS 333

  Fly   561 NGGEHGGGNGGGGMGNN----------GGG 580
            |||.  ||...|||||.          |||
Zfish   334 NGGY--GGQMMGGMGNQSSYGHGGQQMGGG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_SF	51..125	CDD:302621	30/73 (41%)
		RRM2_hnRNPH_like	146..224	CDD:240948	42/77 (55%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:240950	31/73 (42%)
hnrnph1l	NP_997754.2	RRM	<1..>74	CDD:223796	23/65 (35%)
		RRM_SF	6..84	CDD:302621	32/75 (43%)
		RRM	<58..>168	CDD:223796	48/114 (42%)
		RRM_SF	89..184	CDD:302621	45/99 (45%)
		zf-RNPHF	<237..255	CDD:116685	8/109 (7%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	254..329	CDD:241178	31/74 (42%)
		RRM	<254..>310	CDD:223796	23/55 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590310
Domainoid	1	1.000	78	1.000	Domainoid score	I8693
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	1	1.000	-	-		FOG0000855
OrthoInspector	1	1.000	-	-		otm25364
orthoMCL	1	0.900	-	-		OOG6_102542
Panther	1	1.100	-	-	O	PTHR13976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4231
SonicParanoid	1	1.000	-	-		X436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.780