Protein Alignment glo and HNRNPH1

DIOPT Version :10

• Sequence 1: NP_650120.1
• Gene: glo / 41431
• FlyBaseID: FBgn0259139
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001351154.1
• Gene: HNRNPH1 / 3187
• HGNCID: 5041
• Length: 472
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 165/570 - (28%)
• Similarity: 243/570 - (42%)
• Gaps: 200/570 - (35%)

  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115
            |::||||||.:..|:..|..:..:.||:.||..:.:| :|:.:|||:||:.|:::|:.|.|.::.
Human    13 VKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTR-EGRPSGEAFVELESEDEVKLALKKDRE 76

  Fly   116 SMGHRYIEVFTATPKEAKEAMRKISGHG--TA--FVVKLRGLPYAVTEQQIEEFFSGLDIKTDRE 176
            :|||||:|||.:...|....::....:.  ||  ..|:|||||:..::::|.:|||||:|..:
Human    77 TMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPN-- 139

  Fly   177 GILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMK------RATGAG 235
            ||...:|.:||:||||||||.||:..|:||.:::|:|||||||||:||.||::      |...|
Human   140 GITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMA- 203

  Fly   236 GGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGG 300
               ..||||||  ..||.||.|..|.|                 .||..:
Human   204 ---MQRPGPYD--RPGAGRGYNSIGRG-----------------AGFERM--------------- 231

  Fly   301 NNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNN 365
                        ..|.:|||..|.:..|                              |:|.|..
Human   232 ------------RRGAYGGGYGGYDDYN------------------------------GYNDGYG 254

  Fly   366 FNSPGGVNNFGNNGGSNFGGNGGGGFNNGGN-FVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFG 429
            |    |.:.||.:....|.|.....:.:||: |.|::|
Human   255 F----GSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTG--------------------------- 288

  Fly   430 GNNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFE 494
                                                               :.:|||||||.:.|
Human   289 ---------------------------------------------------HCVHMRGLPYRATE 302

  Fly   495 NDVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRG 559
            ||::.||.|:.|..|.|.....|..:|.||..|.|:||:..||.:.:..|..||:|||.: .|.|
Human   303 NDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLN-STAG 366

  Fly   560 LNGG--EH----------GGGNGG-------GGMG----NNGGGNFSRRI 586
            .:||  ||          .|.:||       ||||    ::.||..|:::
Human   367 ASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_hnRNPH_ESRPs_RBM12_like	50..125	CDD:409699	30/73 (41%)
		RRM2_hnRNPH_CRSF1_like	146..224	CDD:409927	41/77 (53%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:409929	32/73 (44%)
HNRNPH1	NP_001351154.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	32/75 (43%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	47/90 (52%)
		zf-RNPHF	255..290	CDD:429823	11/116 (9%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	289..364	CDD:410133	32/75 (43%)