Protein Alignment glo and Hnrnph2

DIOPT Version :10

• Sequence 1: NP_650120.1
• Gene: glo / 41431
• FlyBaseID: FBgn0259139
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001014041.1
• Gene: Hnrnph2 / 308650
• RGDID: 1549784
• Length: 449
• Species: Rattus norvegicus
• Alignment Length: 571
• Identity: 163/571 - (28%)
• Similarity: 249/571 - (43%)
• Gaps: 202/571 - (35%)

  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115
            |::||||||.:.:|::.|..:..:.||::|:..:.:| :|:.:|||:||:.|:::|:.|.|.::.
  Rat    13 VKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVRFIYTR-EGRPSGEAFVELESEDEVKLALKKDRE 76

  Fly   116 SMGHRYIEVFTATPKEAKEAMRKISGHG--TA--FVVKLRGLPYAVTEQQIEEFFSGLDIKTDRE 176
            :|||||:|||.:...|....::....:.  ||  ..|:|||||:..::::|.:|||||:|..:
  Rat    77 TMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPN-- 139

  Fly   177 GILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEM--------KRATG 233
            |:...:|.:||:||||||||.||:..|:||.:::|:|||||||||:||.||:        |..|.
  Rat   140 GMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTM 204

  Fly   234 AGGGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQ 298
            .      ||||||  ..||.||.|..|.|                 .||..    |..|.:|...
  Rat   205 Q------RPGPYD--RPGAGRGYNSIGRG-----------------AGFER----MRRGAYGGGY 240

  Fly   299 GGNNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSG 363
            ||             :.::||.|:|   ..||:|        .||.:....|.|.::
  Rat   241 GG-------------YDDYGGYNDG---YGFGSD--------RFGRDLNYCFSGMSD-------- 273

  Fly   364 NNFNSPGGVNNFGNNGGSNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNF 428
                     :.:|:.|.|               |.|::|
  Rat   274 ---------HRYGDGGSS---------------FQSTTG-------------------------- 288

  Fly   429 GGNNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSF 493
                                                                :.:|||||||.:.
  Rat   289 ----------------------------------------------------HCVHMRGLPYRAT 301

  Fly   494 ENDVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTR 558
            |||::.||.|:.|..|.|.....|..:|.||..|.|:||:..||.:.:..|..||:|||.: .|.
  Rat   302 ENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLN-STA 365

  Fly   559 GLNGGEH------------GGGNGG-------GGMG----NNGGGNFSRRI 586
            |.:||.:            .|.:||       ||||    ::.||..|:::
  Rat   366 GTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_hnRNPH_ESRPs_RBM12_like	50..125	CDD:409699	29/73 (40%)
		RRM2_hnRNPH_CRSF1_like	146..224	CDD:409927	40/77 (52%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:409929	32/73 (44%)
Hnrnph2	NP_001014041.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	31/75 (41%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	46/90 (51%)
		2 X 16 AA Gly-rich approximate repeats	234..433		67/318 (21%)
		zf-RNPHF	257..290	CDD:429823	11/150 (7%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	289..364	CDD:410133	32/75 (43%)
		2 X 19 AA perfect repeats	354..392		12/38 (32%)