Protein Alignment glo and GRSF1

DIOPT Version :10

• Sequence 1: NP_650120.1
• Gene: glo / 41431
• FlyBaseID: FBgn0259139
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_002083.4
• Gene: GRSF1 / 2926
• HGNCID: 4610
• Length: 480
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 128/549 - (23%)
• Similarity: 203/549 - (36%)
• Gaps: 204/549 - (37%)

  Fly    27 QDEDDQYNED---------GGGKIENVGESPKFVRLRGLPWSATHKEILDFLENVNVTNGSAGIH 82
            |:....|.||         ...|:|...:....:|.:|||||.|.:::|:|..:..:.||..|||
Human   119 QESKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIH 183

  Fly    83 LVTSRVDGKNTGEAYVEVASQEDVEEARKLNKASMGHRYIEVFTATPKEAKEAMRKISGHGTAF- 146
            .:.:| |||..|:|.:|:.|::||::|.:.::..||.||:||:....::....|:.:....:..
Human   184 FLLNR-DGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKSSPVV 247

  Fly   147 ---VVKLRGLPYAVTEQQIEEFFSGLDIKTDREGILFVMDRRG-RATGEAFVQFESQDDTEQALG 207
               ||:||||||:..|:.|.:||:||:|    ..|.||||.|| |.||||:||||..:...|||.
Human   248 NDGVVRLRGLPYSCNEKDIVDFFAGLNI----VDITFVMDYRGRRKTGEAYVQFEEPEMANQALL 308

  Fly   208 RNREKIGHRYIEIFRSSIAEMKRATGA--GGGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNG 270
            ::||:||:||||||.|...|::...|:  |..:...|....|.:
Human   309 KHREEIGNRYIEIFPSRRNEVRTHVGSYKGKKIASFPTAKYITE--------------------- 352

  Fly   271 NFGVGANNMLGFNNLPSLMNSGNFGNNQGGNNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGN 335
                           |.::    |..::      ...:..|..
Human   353 ---------------PEMV----FEEHE------VNEDIQPMT---------------------- 370

  Fly   336 SGNFGNFGNNGGGNFGGNNNGGGGFNSGNNFNSPGGVNNFGNNGGSNFGGNGGGGFNNGGNFVSS 400
                                   .|.|......|..|..
Human   371 -----------------------AFESEKEIELPKEVPE-------------------------- 386

  Fly   401 SGVGNFGPIGGGRNNNNGNFGNSGFGNFGGNNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGG 465
                                                           .....::||..:|:
Human   387 -----------------------------------------------KLPEAADFGTTSSL---- 400

  Fly   466 NFGPIGGGRGNDIEYYTIHMRGLPYTSFENDVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTY 530
                           :.:||||||:.:...|:..||.|::|..:.:.|:..|..:|.||.:|:|:
Human   401 ---------------HFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFETH 450

  Fly   531 EDSQVAMKRHREQMGSRYIELFYDGKTRG 559
            ||:..||.:.|..:..||||||.:...:|
Human   451 EDAVAAMLKDRSHVHHRYIELFLNSCPKG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_hnRNPH_ESRPs_RBM12_like	50..125	CDD:409699	30/74 (41%)
		RRM2_hnRNPH_CRSF1_like	146..224	CDD:409927	44/82 (54%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:409929	29/73 (40%)
GRSF1	NP_002083.4	RRM1_GRSF1	149..227	CDD:410129	31/78 (40%)
		RRM2_GRSF1	249..325	CDD:409928	44/79 (56%)
		RRM3_GRSF1	401..475	CDD:410132	29/73 (40%)