DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment glo and sym-2

DIOPT Version :9

Sequence 1:	NP_650120.1	Gene:	glo / 41431	FlyBaseID:	FBgn0259139	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_495960.2	Gene:	sym-2 / 174461	WormBaseID:	WBGene00006367	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	210	Identity:	81/210 - (38%)
Similarity:	121/210 - (57%)	Gaps:	25/210 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EDDQYNEDGGGKIENVGESPKFVRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNT 93
            ||.:...||    :||     ..|.|||||.|:...:..|...:::..|  ||.|..|. :|:..
Worm   170 EDQEVGADG----DNV-----VCRARGLPWQASDHHVAQFFAGLDIVPG--GIALCLSS-EGRRN 222

  Fly    94 GEAYVEVASQEDVEEARKLNKASMGHRYIEVFTATPKE--------AKEAMRKISGHGTAFVVKL 150
            ||..|:.:|||..:.|.|.::..:..|||||:.|...|        :.|||..:|.:  |.:|::
Worm   223 GEVLVQFSSQESRDLALKRHRNFLLSRYIEVYKAGLDEFMHVATGSSTEAMEFVSAN--AIIVRM 285

  Fly   151 RGLPYAVTEQQIEEFFSGLDIKTDREGILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGH 215
            |||||..|:.||..||..|.: ||:  |||:....||.||:||||||:::|.:|.|.::|:.||.
Worm   286 RGLPYDCTDAQIRTFFEPLKL-TDK--ILFITRTDGRPTGDAFVQFETEEDAQQGLLKHRQVIGQ 347

  Fly   216 RYIEIFRSSIAEMKR 230
            ||||:|:|:.||:::
Worm   348 RYIELFKSTAAEVQQ 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glo	NP_650120.1	RRM_SF	51..125	CDD:302621	26/73 (36%)
		RRM2_hnRNPH_like	146..224	CDD:240948	38/77 (49%)
		RRM3_hnRNPH_CRSF1_like	481..555	CDD:240950
sym-2	NP_495960.2	RRM1_ESRPs_Fusilli	182..256	CDD:240951	27/76 (36%)
		RRM2_ESRPs_Fusilli	281..355	CDD:240952	38/76 (50%)
		RRM	<282..446	CDD:223796	41/84 (49%)
		RRM3_Fusilli	388..472	CDD:241187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I6431
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870